ニッキング・クロージング酵素
WordNet
- final or ending; "the closing stages of the election"; "the closing weeks of the year"; "the closing scene of the film"; "closing remarks"
- approaching a particular destination; a coming closer; a narrowing of a gap; "the ships rapid rate of closing gave them little time to avoid a collision" (同)closure
- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
PrepTutorEJDIC
- 閉じる,終りの / 〈U〉閉じること,閉鎖 / 〈C〉〈U〉終了,締め切り;決算
- 酵素
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/01 04:14:12」(JST)
[Wiki en表示]
| DNA topoisomerase |
| Identifiers |
| EC number |
5.99.1.2 |
| CAS number |
80449-01-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase, omega-protein, deoxyribonucleate topoisomerase) is an enzyme with system name DNA topoisomerase.[1] This enzyme catalyses the following chemical reaction
- ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
These enzymes bring about the conversion of one topological isomer of DNA into another.
References
- ^ Gellert, M. (1981). "DNA topoisomerases". Annu. Rev. Biochem. 50: 879–910. doi:10.1146/annurev.bi.50.070181.004311. PMID 6267993.
See also
External links
- DNA topoisomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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Isomerase: topoisomerases (EC 5.99)
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| 5.99.1 |
- Type I topoisomerase
- Type II topoisomerase
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Proteins: enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation.
- Wang Z1, D'Annessa I1, Tesauro C1, Croce S1, Ottaviani A1, Fiorani P2, Desideri A3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1854(8):860-8. doi: 10.1016/j.bbapap.2015.04.017. Epub 2015 Apr 22.
- Human topoisomerase 1B controls the topological state of supercoiled DNA allowing the progression of fundamental cellular processes. The enzyme, which is the unique molecular target of the natural anticancer compound camptothecin, acts by cleaving one DNA strand and forming a transient protein-DNA c
- PMID 25910424
- Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites.
- Huang SY1, Ghosh S1, Pommier Y2.
- The Journal of biological chemistry.J Biol Chem.2015 May 29;290(22):14068-76. doi: 10.1074/jbc.M115.653345. Epub 2015 Apr 17.
- Ribonucleotide monophosphates (rNMPs) are among the most frequent form of DNA aberration, as high ratios of ribonucleotide triphosphate:deoxyribonucleotide triphosphate pools result in approximately two misincorporated rNMPs/kb of DNA. The main pathway for the removal of rNMPs is by RNase H2. Howeve
- PMID 25887397
- DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.
- Wright CM1, van der Merwe M2, DeBrot AH1, Bjornsti MA3.
- The Journal of biological chemistry.J Biol Chem.2015 May 8;290(19):12068-78. doi: 10.1074/jbc.M114.635078. Epub 2015 Mar 20.
- During processes such as DNA replication and transcription, DNA topoisomerase I (Top1) catalyzes the relaxation of DNA supercoils. The nuclear enzyme is also the cellular target of camptothecin (CPT) chemotherapeutics. Top1 contains four domains: the highly conserved core and C-terminal domains invo
- PMID 25795777
Japanese Journal
- A procedure for quantiation of closed circular DNA in the presence of superhelical DNA : an improved fluorometric assay for nicking-closing enzyme.
Related Links
- Nicking closing enzyme information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Nicking closing enzyme: Related Topics These medical condition or symptom topics may ...
- A DNA nicking-closing enzyme has been purified from the nuclei of mouse L cells to 90% homogeneity. The denatured and reduced form of the enzyme has a molecular weight of 68,000 which is in agreement with the molecular ...
★リンクテーブル★
[★]
- 英
- nicking-closing enzyme
- 関
- DNAトポイソメラーゼ、I型トポイソメラーゼ
[★]