English Journal

Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease.

Vickers JC1, Kirkcaldie MT2, Phipps A3, King AE3.
Brain research bulletin.Brain Res Bull.2016 Sep;126(Pt 3):324-333. doi: 10.1016/j.brainresbull.2016.07.012. Epub 2016 Jul 27.
Neurofilaments are major protein constituents of the brain, but are particularly abundant in specific subpopulations of neurons and likely have a key role in the regulation of axonal calibre. Neurofilament proteins may also be involved in the transformation of the neuronal cytoskeleton leading to su
PMID 27475416

Familial amyotrophic lateral sclerosis with an I104F mutation in the SOD1 gene: Multisystem degeneration with neurofilamentous aggregates and SOD1 inclusions.

Jiang H1,2, Shimizu H1, Shiga A3, Tanaka M4,5, Onodera O3, Kakita A1, Takahashi H1.
Neuropathology : official journal of the Japanese Society of Neuropathology.Neuropathology.2016 Jul 22. doi: 10.1111/neup.12324. [Epub ahead of print]
We previously reported familial amyotrophic lateral sclerosis (FALS) of 11 years duration in a 57-year-old woman, who received artificial ventilation for 5 years prior to death and exhibited widespread multisystem degeneration and neurofilamentous aggregates, so-called conglomerate inclusions (CIs
PMID 27444855

LoPachin RM1, Gavin T2.
Neuroscience letters.Neurosci Lett.2015 Jun 2;596:78-83. doi: 10.1016/j.neulet.2014.08.054. Epub 2014 Sep 16.
2,5-Hexanedione (HD) and acrylamide (ACR) are considered to be prototypical among chemical toxicants that cause central-peripheral axonopathies characterized by distal axon swelling and degeneration. Because the demise of distal regions was assumed to be causally related to the onset of neurotoxicit
PMID 25218479

Japanese Journal

Role of proteasomes in the formation of neurofilamentous inclusions in spinal motor neurons of aluminum-treated rabbits

KIMURA Noriyuki,KUMAMOTO Toshihide,UEYAMA Hidetsugu,HORINOUCHI Hideo,OHAMA Eisaku
Neuropathology : official journal the Japanese Society of Neuropathology 27(6), 522-530, 2007-12-01
NAID 10021236845

須貝文宣,山本洋一,佐古田三郎
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124(1), 19-23, 2004-07-01
筋萎縮性側索硬化症（ALS）は，緩徐進行性に上位および下位運動神経が障害されるために，四肢のみならず嚥下·会話·呼吸に関する筋力も低下し日常生活機能が著しく損なわれる極めて予後不良の神経変性疾患である．ALSのほとんどは孤発性であり，その病因としてグルタミン酸毒性，酸化的ストレス，ニューロフィラメントの構造異常などが想定されているが，未だ原因の確定には至っていない．一方，ヒトALS患者の1-2%が …
NAID 10013796615

Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons

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