English Journal

Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae).

Mustafa AM1, Maggi F2, Papa F3, Kaya E4, Dikmen M4, Öztürk Y4.
Food chemistry.Food Chem.2016 Feb 1;192:782-7. doi: 10.1016/j.foodchem.2015.07.079. Epub 2015 Jul 21.
In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. Isofuranodiene is the major constituent of the essential oil of wild celery (
PMID 26304411

A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.

Sugitani K1, Koriyama Y2, Ogai K3, Wakasugi K4, Kato S5.
Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:671-5. doi: 10.1007/978-3-319-17121-0_89.
Neuroglobin (Ngb) is a new member of the family of heme proteins and is specifically expressed in neurons of the central and peripheral nervous systems in all vertebrates. In particular, the retina has a 100-fold higher concentration of Ngb than do other nervous tissues. The role of Ngb in the retin
PMID 26427474

Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4.

Schröder P1,2, Förster T1,2, Kleine S2, Becker C2, Richters A2, Ziegler S1, Rauh D2, Kumar K1,2, Waldmann H3,4.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2015 Oct 12;54(42):12398-403. doi: 10.1002/anie.201501515. Epub 2015 Apr 23.
Progressive loss and impaired restoration of neuronal activity are hallmarks of neurological diseases, and new small molecules with neurotrophic activity are in high demand. The militarinone alkaloids and structurally simplified analogues with 4-hydroxy-2-pyridone core structure induce pronounced ne
PMID 25908259

Japanese Journal

Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus

QU Yuan,SUN Kaiyue,GAO Lijuan [他],SAKAGAMI Youji,KAWAGISHI Hirokazu,OJIKA Makoto,QI Jianhua
Bioscience, biotechnology, and biochemistry 76(4), 791-793, 2012-04-23
… (Berk.) Herm., and exhibited neuritogenic activity against PC12 cells. … Termitomycesphin G with a 16-carbon-chain fatty acid showed higher neuritogenic activity than that of termitomycesphin H with an 18-carbon-chain fatty acid. … This effect was observed within the termitomycesphins, suggesting that the chain length of the fatty acyl moiety played a key role in the neuritogenic activity. …
NAID 10030751968

Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor β expression through nitric oxide/S-nitrosylation signaling

Koriyama Yoshiki,Takagi Yusuke,Chiba Kenzo,Yamazaki Matsumi,Arai Kunizo,Matsukawa Toru,Suzuki Hirokazu,Sugitani Kayo,Kagechika Hiroyuki,Kato Satoru
Journal of Neurochemistry 119(6), 1232-1242, 2011-12-00
… Genipin, a herbal iridoid, is known to have both neuroprotective and neuritogenic activity in neuronal cell lines. … In the present study, we investigated another neuritogenic property of IPRG001 in RGC-5 cells and retinal explant culture where in we focused on the NO-cGMP-dependent and protein S-nitrosylation pathways. … The both neuroprotective and neuritogenic activities of genipin could be a new target for the regeneration of retinal ganglion cells after glaucomatous conditions. …
NAID 120003628232

Qu Yuan,Zhang Yang,Pei Liang [他],WANG Yan,GAO Lijuan,HUANG Qianming,OJIKA Makoto,SAKAGAMI Youji,QI Jianhua
Bioscience, biotechnology, and biochemistry 75(6), 1201-1204, 2011-06-23
… It exhibited significant neuritogenic activity for PC12 cells. … The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity. …
NAID 10029328596