English Journal

CaMKIIβ-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis.

Saito A, Miyajima K, Akatsuka J, Kondo H, Mashiko T, Kiuchi T, Ohashi K, Mizuno K.SourceDepartment of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Genes to cells : devoted to molecular & cellular mechanisms.Genes Cells.2013 Jul;18(7):533-43. doi: 10.1111/gtc.12054. Epub 2013 Apr 18.
LIM-kinase 1 (LIMK1) regulates actin cytoskeletal reorganization by phosphorylating and inactivating actin-depolymerizing factor and cofilin. We examined the role of LIMK1 in brain-derived neurotrophic factor (BDNF)-induced neuritogenesis in primary-cultured rat cortical neurons. Knockdown of LIMK1
PMID 23600483

Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis.

Kondo K, Pak K, Chavez E, Mullen L, Euteneuer S, Ryan AF.Source1Division of Otolaryngology and Neurosciences, Department of Surgery and Veterans Administration Medical Center, University of California, San Diego School of Medicine , La Jolla, CA , USA.
The International journal of neuroscience.Int J Neurosci.2013 Jul;123(7):465-75. doi: 10.3109/00207454.2013.764497. Epub 2013 Feb 11.
Developmental changes in responsiveness of rat spiral ganglion neurons (SGNs) to neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) were examined using an explant culture system. Spiral ganglion (SG) explants at embryonic Day 18 (E18), postnatal Day 0 (P0), P5, P10 and P20 were cultu
PMID 23301942

Parkinson's disease cybrids, differentiated or undifferentiated, maintain morphological and biochemical phenotypes different from those of control cybrids.

Appukuttan TA, Ali N, Varghese M, Singh A, Tripathy D, Padmakumar M, Gangopadhyay PK, Mohanakumar KP.SourceDivision of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Journal of neuroscience research.J Neurosci Res.2013 Jul;91(7):963-70. doi: 10.1002/jnr.23241. Epub 2013 May 7.
SH-SY5Y, control, and Parkinson's disease (PD) cybrids prepared from an Indian population were differentiated using retinoic acid (RA) for understanding their dopaminergic characteristics and neuritogenesis. Undifferentiated control and PD cybrids exhibited higher levels of TH mRNA, but lower c-RET
PMID 23653325

Japanese Journal

Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons

Tsuji Takahiro,Higashida Chiharu,Aoki Yoshihiko,Saharul Islam Mohammad,Dohmoto Mitsuko,Higashida Haruhiro
Neurochemistry International 61(6), 854-858, 2012-11
… Next, the effects of Ect2 depletion were studied in primary cultures of mouse embryonic cortical neurons: Loss of Ect2 did not affect the differentiation stages of neuritogenesis, the number of neurites, or axon length, while the numbers of growth cones and growth cone-like structures were increased. …
NAID 120004966610