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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/07 09:34:30」(JST)
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A neurite refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete.
Neurites are often packed with microtubule bundles, the growth of which is stimulated by Nerve Growth Factor (NGF), as well as tau proteins, MAP1 proteins, and MAP2.[1]
The neural cell adhesion molecule N-CAM simultaneously combines with another N-CAM and a fibroblast growth factor receptor to stimulate the tyrosine kinase activity of that receptor to induce the growth of neurites.
There are several software kits available to facilitate neurite tracing in images (see external links).
Weak endogeneous electric fields may be used to both facilitate and direct the growth of projections from cell soma neurites, EFs of moderate strength have been used to direct and enhance neurite outgrowth in both murine and xenopus models. Co-culture of neurons with electrically aligned glial tissue also directs neurite outgrowth, as it is rich in neurotrophins that promote nerve growth.
See also
- Lewy neurites
- Unipolar neuron
References
- ^ Bear, Mark F; Connors, Barry W.; Paradiso, Michael A., Neuroscience, Exploring the Brain, Philadelphia : Lippincott Williams & Wilkins; Third Edition (February 1, 2006). ISBN 0-7817-6003-8
External links
- E Meijering's article on the state of neurite detection
- NeuronJ neurite tracing program
- SynD synapse and neurite detection program
UpToDate Contents
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English Journal
- Vertical electric field stimulated neural cell functionality on porous amorphous carbon electrodes.
- Jain S, Sharma A, Basu B.SourceDepartment of Materials Science and Engineering, Indian Institute of Technology, Kanpur 208016, India; Materials Research Centre, Indian Institute of Science, Bangalore 560012, India.
- Biomaterials.Biomaterials.2013 Dec;34(37):9252-63. doi: 10.1016/j.biomaterials.2013.08.057. Epub 2013 Sep 10.
- We demonstrate the efficacy of amorphous macroporous carbon substrates as electrodes to support neuronal cell proliferation and differentiation in electric field mediated culture conditions. The electric field was applied perpendicular to carbon substrate electrode, while growing mouse neuroblastoma
- PMID 24034501
- Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide.
- Smith Callahan LA, Xie S, Barker IA, Zheng J, Reneker DH, Dove AP, Becker ML.SourceDepartment of Polymer Science, The University of Akron, Akron, OH 44325, USA.
- Biomaterials.Biomaterials.2013 Dec;34(36):9089-95. doi: 10.1016/j.biomaterials.2013.08.028. Epub 2013 Sep 3.
- End-functional PLLA nanofibers were fabricated into mats of random or aligned fibers and functionalized post-spinning using metal-free "click chemistry" with the peptide Tyr-Ile-Gly-Ser-Arg (YIGSR). Fibers that were both aligned and functionalized with YIGSR were found to significantly increase the
- PMID 24008044
- Schwann cell migration and neurite outgrowth are influenced by media conditioned by epineurial fibroblasts.
- van Neerven SG, Pannaye P, Bozkurt A, Van Nieuwenhoven F, Joosten E, Hermans E, Taccola G, Deumens R.SourceDepartment of Plastic Surgery, Reconstructive and Hand Surgery, Burn Center, Medical Faculty, RWTH Aachen University, Aachen, Germany.
- Neuroscience.Neuroscience.2013 Nov 12;252C:144-153. doi: 10.1016/j.neuroscience.2013.08.009. Epub 2013 Aug 15.
- The regenerative capacity of the peripheral nervous system is largely related to Schwann cells undergoing proliferation and migration after injury and forming growth-supporting substrates for severed axons. Novel data show that fibroblasts to a certain extent regulate the pro-regenerative behavior o
- PMID 23954802
Japanese Journal
- In vitroおよびin vivoにおけるデキサメタゾンによるうつ病発症機構の解明
- DA-9801 Promotes Neurite Outgrowth via ERK1/2-CREB Pathway in PC12 Cells
- , , [他], , , , , ,
- Biological and Pharmaceutical Bulletin 38(2), 169-178, 2015
- … In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. … DA-9801, an extract from a mixture of Dioscorea japonica and Dioscorea nipponica, was reported to promote neurite outgrowth in PC12 cells. … In the presence of nerve growth factor (NGF, 2 ng/mL), DA-9801 promoted neurite outgrowth and increased the relative mRNA levels of neurofilament-L (NF-L), a marker of neuronal differentiation. …
- NAID 130004872243
- Splicing Variants of NOL4 Differentially Regulate the Transcription Activity of Mlr1 and Mlr2 in Cultured Cells
- Takayanagi-Kiya Seika,Misawa-Hojo Kayo,Kiya Taketoshi [他]
- Zoological science 31(11), 735-740, 2014-11
- NAID 40020278707
Related Links
- A neurite refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be ...
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