English Journal

Integrin αvβ3 targeting activity study of different retro-inverso sequences of RGD and their potentiality in the designing of tumor targeting peptides.

Liu Y1, Mei L1, Yu Q1, Zhang Q1, Gao H1, Zhang Z1, He Q2.
Amino acids.Amino Acids.2015 Dec;47(12):2533-9. doi: 10.1007/s00726-015-2043-9. Epub 2015 Jul 15.
Retro-inverso peptide represented the isomer of a parent peptide in which the direction of the sequence was reversed and the chirality of each amino acid residue was inverted. Generally, retro-inverso peptides possessed equal or even higher activities compared to the original peptide. RGD was a comm
PMID 26173509

Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy.

Economopoulou M1, Avramovic N, Klotzsche-von Ameln A, Korovina I, Sprott D, Samus M, Gercken B, Troullinaki M, Grossklaus S, Funk RH, Li X, Imhof BA, Orlova VV, Chavakis T.
Thrombosis and haemostasis.Thromb Haemost.2015 Nov 25;114(6):1241-9. doi: 10.1160/TH15-01-0051. Epub 2015 Aug 27.
In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors
PMID 26311310

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.

Nanda V1, Downing KP1, Ye J1, Xiao S1, Kojima Y1, Spin JM2, DiRenzo DM1, Nead K3, Connolly AJ4, Dandona S5, Perisic L6, Hedin U6, Maegdefessel L7, Dalman J1, Guo L8, Zhao X8, Kolodgie FD8, Virmani R8, Davis HR8, Leeper N9.
Circulation research.Circ Res.2015 Nov 23. pii: CIRCRESAHA.115.307906. [Epub ahead of print]
RATIONALE: Genetic variation at the chromosome 9p21 cardiovascular risk locus has been associated with peripheral artery disease (PAD), but its mechanism remains unknown.OBJECTIVE: To determine whether this association is secondary to an increase in atherosclerosis, or is the result of a separate an
PMID 26596284

Japanese Journal

曽根曜子,越智榮子,松山晃子 [他],普久原聡子,合田光寛,髙取真吾,川博已
YAKUGAKU ZASSHI 132(2), 157-160, 2012
… Therefore, the aim of this study is to investigate effect of NGF on distribution of perivascular nerves and neovessel form in tumor tissues, which were generated by mouse corneal micropocket method. …
NAID 130001872001

Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases

Kim Seung-Ae,Lee Hyo-Jeong,Ahn Kwang Seok [他],Lee Hyo-Jung,Lee Eun-Ok,Ahn Kyoo-Seok,Choi Seung-Hoon,Jung Soo-Jin,Kim Ji Young,Baek Namin,Kim Sung-Hoon
Biological and Pharmaceutical Bulletin 32(7), 1142-1147, 2009
… In addition, paeonol significantly suppressed neovessel formation on bFGF-treated chick chorioallantoic membrane (CAM) and disrupted bFGF-induced neovascularization in Matrigel plug assay in vivo. …
NAID 130000117207

Evaluation of the Antiangiogenic Effects of 2-Aryl-3-bromoquinolin-4(1H)-ones and a NCH3-4-oxo Derivative

Mabeta Peace,Auer Roland,Mphahlele Malose Jack
Biological and Pharmaceutical Bulletin 32(5), 937-940, 2009
… The compounds also inhibited neovessel growth in an ex vivo assay of angiogenesis. …
NAID 130000117164