新生児糖尿病
WordNet
- relating to or affecting the infant during the first month after birth; "neonatal care"; "the neonatal period"
- a polygenic disease characterized by abnormally high glucose levels in the blood; any of several metabolic disorders marked by excessive urination and persistent thirst
PrepTutorEJDIC
- 新生児の
- 糖尿病(尿に糖が異常に出る病気)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/03 01:52:15」(JST)
[Wiki en表示]
Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of life. It is a rare disease, occurring in only one in 100,000 to 500,000 live births. Infants with NDM do not produce enough insulin, leading to an increase in blood glucose. NDM can be mistaken for the much more common type 1 diabetes, but type 1 diabetes usually occurs later than the first 6 months of life. In about half of those with NDM, the condition is lifelong and is called permanent neonatal diabetes mellitus (PNDM). In the rest of those with NDM, the condition is transient and disappears during infancy but can reappear later in life; this type of NDM is called transient neonatal diabetes mellitus (TNDM). Specific genes that can cause NDM have been identified.[1]
Symptoms of NDM include frequent urination, and dehydration. NDM can be diagnosed by finding elevated levels of glucose in blood or urine. In severe cases, the deficiency of insulin may cause the body to produce an excess of acid, resulting in a potentially life-threatening condition called ketoacidosis. Most fetuses with NDM do not grow well in the womb and newborns are much smaller than those of the same gestational age, a condition called intrauterine growth restriction. After birth, some infants fail to gain weight and growth as rapidly as other infants of the same age and sex. Appropriate therapy improves and may normalize growth and development.[1]
In many cases, neonatal diabetes may be treated with oral sulfonylureas such as glyburide. Physicians may order genetic tests to determine whether or not transitioning from insulin to sulfonylurea drugs is appropriate for a patient. A 2006 study showed that 90% of patients with a KCNJ11 mutation were able to successfully transition to sulfonylurea therapy.[2]
References[edit]
- ^ a b Monogenic Forms of Diabetes: Neonatal Diabetes Mellitus and Maturity-onset Diabetes of the Young at National Diabetes Information Clearinghouse, a service of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. NIH Publication No. 07–6141. March 2007. Copyright cite: This publication is not copyrighted.
- ^ Pearson ER; Flechtner I, Njolstad PR, et al. (2006). "Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations". New England Journal of Medicine 355 (5): 467–477.
- Yorifuji, T; Kurokawa, K; Mamada, M; Imai, T; Kawai, M; Nishi, Y; Shishido, S; Hasegawa, Y; Nakahata, T (2004 Jun). "Neonatal diabetes mellitus and neonatal polycystic, dysplastic kidneys: Phenotypically discordant recurrence of a mutation in the hepatocyte nuclear factor-1beta gene due to germline mosaicism.". The Journal of clinical endocrinology and metabolism 89 (6): 2905–8. PMID 15181075.
- Edghill, EL; Bingham, C; Slingerland, AS; Minton, JA; Noordam, C; Ellard, S; Hattersley, AT (2006 Dec). "Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development.". Diabetic medicine : a journal of the British Diabetic Association 23 (12): 1301–6. PMID 17116179.
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Diabetes (E10–E14, 250)
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| Types of diabetes |
- Prediabetes
- Impaired fasting glucose
- Impaired glucose tolerance
- Insulin resistance
- Conventional insulinotherapy
- Type 1
- LADA
- Type 2
- KPD
- MODY
- NDM
- Glossary of diabetes
- Diabetes and pregnancy: Gestational diabetes
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| Blood tests |
- Blood sugar
- Glycosylated hemoglobin
- Glucose tolerance test
- Fructosamine
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| Diabetes management |
- Diabetic diet
- Anti-diabetic drugs
- Oral anti-diabetic drugs and insulin analogs
- Insulin therapy
- Intensive insulinotherapy
- Pulsatile insulin
- Cure
- Embryonic stem cells
- Gastric bypass surgery
- Artificial pancreas
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| Complications/prognosis |
- Diabetic comas
- Diabetic hypoglycemia
- Diabetic ketoacidosis
- Hyperglycemic hyperosmolar state
- Diabetic angiopathy
- Diabetic foot
- ulcer
- Neuropathic arthropathy
- Diabetic myonecrosis
- Diabetic nephropathy
- Diabetic neuropathy
- Diabetic retinopathy
- Diabetic cardiomyopathy
- Diabetic dermadrome
- Diabetic dermopathy
- Diabetic bulla
- Diabetic cheiroarthropathy
- Neuropathic ulcer
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| Other |
- Hypoglycemia/Hyperglycemia
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noco (d)/cong/tumr, sysi/epon
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proc, drug (A10/H1/H2/H3/H5)
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UpToDate Contents
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English Journal
- Clinical outcomes of adult inpatients treated with continuous subcutaneous insulin infusion for diabetes mellitus: a systematic review.
- Anstey J1,2, Yassaee A1,2, Solomon A2,3.
- Diabetic medicine : a journal of the British Diabetic Association.Diabet Med.2015 Oct;32(10):1279-88. doi: 10.1111/dme.12740. Epub 2015 Mar 31.
- AIMS: To provide a systematic review of the current evidence concerning the diabetes-related outcomes of patients provided with continuous subcutaneous insulin infusion for treating diabetes mellitus while a hospital inpatient.METHODS: Relevant publications were obtained from MEDLINE and EMBASE data
- PMID 25763540
- Excessive gestational weight gain and gestational diabetes: importance of the first weeks of pregnancy.
- Robitaille J1.
- Diabetologia.Diabetologia.2015 Oct;58(10):2203-5. doi: 10.1007/s00125-015-3725-2. Epub 2015 Aug 8.
- Gestational diabetes mellitus (GDM) is associated with many adverse neonatal and maternal outcomes and prevention of this condition is considered a key strategy for breaking the intergenerational cycle of obesity and diabetes. Whether prevention of excessive gestational weight gain in the first week
- PMID 26253766
- Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.
- Mathison A1, Escande C1, Calvo E1, Seo S1, White T1, Salmonson A1, Faubion WA Jr1, Buttar N1, Iovanna J1, Lomberk G1, Chini EN1, Urrutia R1.
- Endocrinology.Endocrinology.2015 Oct;156(10):3581-95. doi: 10.1210/en.2015-1145. Epub 2015 Aug 6.
- We have previously shown that amino acid changes in the human Kruppel-Like Factor (KLF) 11 protein is associated with the development of maturity onset diabetes of the young VII, whereas complete inactivation of this pathway by the -331 human insulin mutation causes neonatal diabetes mellitus. Here,
- PMID 26248217
Japanese Journal
- A case of a Japanese patient with neonatal diabetes mellitus caused by a novel mutation in the ABCC8 gene and successfully controlled with oral glibenclamide
- Women with rigorously managed overt diabetes during pregnancy do not experience adverse infant outcomes but do remain at serious risk of postpartum diabetes
- 1. 妊娠糖尿病と妊娠高血圧症候群の後の生涯管理(クリニカルカンファレンス10-Subspecialtyを越えて(周産期・女性ヘルスケア)-,生涯研修プログラム,第66回日本産科婦人科学会学術講演会講演要旨)
Related Links
- Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of life. It is a rare disease, occurring in only one in 100,000 to 500,000 live births. Infants with NDM do not produce enough insulin, leading to an increase in ...
- [Top] What is neonatal diabetes mellitus (NDM)? NDM is a monogenic form of diabetes that occurs in the first 6 months of life. It is a rare condition occurring in only one in 100,000 to 500,000 live births. Infants with NDM do not ...
★リンクテーブル★
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- 英
- neonatal diabetes mellitus
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- 関
- neonatal period、neonatally、neonate、newborn、newborn animal、newborn infant
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- 関
- 糖尿病 diabetes mellitus DM