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English Journal

Immunogenicity and safety of investigational vaccine formulations against meningococcal serogroups A, B, C, W and Y in healthy adolescents.

Saez-Llorens X1, Aguilera Vaca DC, Abarca K, Maho E, Graña MG, Heijnen E, Smolenov I, Dull PM.
Human vaccines & immunotherapeutics.Hum Vaccin Immunother.2015 May 13:0. [Epub ahead of print]
This phase 2 study assessed the immunogenicity, safety, and reactogenicity of investigational formulations of meningococcal ABCWY vaccines, consisting of recombinant proteins (rMenB) and outer membrane vesicle (OMV) components of a licensed serogroup B vaccine, combined with components of a license
PMID 25969894

A large portion of meningococcal antigen typing system-negative meningococcal strains from spain is killed by sera from adolescents and infants immunized with 4CMenB.

Abad R1, Biolchi A2, Moschioni M2, Giuliani MM2, Pizza M2, Vázquez JA3.
Clinical and vaccine immunology : CVI.Clin Vaccine Immunol.2015 Apr;22(4):357-60. doi: 10.1128/CVI.00669-14. Epub 2015 Jan 28.
A new vaccine (the 4CMenB 4-component protein vaccine [Bexsero], which includes PorA, factor H-binding protein [fHbp], neisserial heparin-binding antigen [NHBA], and Neisseria adhesin A [NadA]) against serogroup B meningococci has recently been approved for use in people older than age 2 months in E
PMID 25630407

The meningococcal autotransporter AutA is implicated in autoaggregation and biofilm formation.

Arenas J1, Cano S, Nijland R, van Dongen V, Rutten L, van der Ende A, Tommassen J.
Environmental microbiology.Environ Microbiol.2015 Apr;17(4):1321-37. doi: 10.1111/1462-2920.12581. Epub 2014 Sep 9.
Autotransporters (ATs) are proteins secreted by Gram-negative bacteria that often play a role in virulence. Eight different ATs have been identified in Neisseria meningitidis, but only six of them have been characterized. AutA is one of the remaining ATs. Its expression remains controversial. Here,
PMID 25059714