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Programmable bio-nanochip technology for the diagnosis of cardiovascular disease at the point-of-care.

Christodoulides N1, Pierre FN, Sanchez X, Li L, Hocquard K, Patton A, Muldoon R, Miller CS, Ebersole JL, Redding S, Yeh CK, Furmaga WB, Wampler DA, Bozkurt B, Ballantyne CM, McDevitt JT.
Methodist DeBakey cardiovascular journal.Methodist Debakey Cardiovasc J.2012 Jan;8(1):6-12.
Cardiovascular disease remains the leading cause of death in the world and continues to serve as the major contributor to healthcare costs. Likewise, there is an ever-increasing need and demand for novel and more efficient diagnostic tools for the early detection of cardiovascular disease, especiall
PMID 22891104

Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

Albayrak M1, Konyssova U, Kaya Z, Gursel T, Guntekin S, Percin EF, Kocak U.
Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2011 Nov;68(5):1155-9. doi: 10.1007/s00280-011-1599-7. Epub 2011 Mar 13.
PURPOSE: Thiopurine methyltransferase (TPMT) enzyme is involved in the metabolism of 6-mercaptopurine (6-MP), a key component of acute lymphoblastic leukemia (ALL) treatment protocols in children. The aims of this study were to investigate the frequency of common genetic polymorphisms associated wit
PMID 21400026

Development of novel microarray methodology for the study of mutations in the SERPINA1 and ADRB2 genes--their association with Obstructive Pulmonary Disease and Disseminated Bronchiectasis in Greek patients.

Papatheodorou A1, Makrythanasis P, Kaliakatsos M, Dimakou A, Orfanidou D, Roussos C, Kanavakis E, Tzetis M.
Clinical biochemistry.Clin Biochem.2010 Jan;43(1-2):43-50. doi: 10.1016/j.clinbiochem.2009.08.026. Epub 2009 Sep 10.
OBJECTIVES: The aim of our study was to determine the genetic risk conferred by SNPs in the SERPINA1 and ADRB2 for development of Chronic Obstructive Pulmonary Disease (COPD) and Disseminated Bronchiectasis (DB), while at the same time validating the NanoChip technology. This was a case-control stud
PMID 19747908

岡田浩樹
分析化学 57(7), 573-574, 2008-07-05
… Given the trajectory of interest and innovation in this marriage of micro and nano-chip technology and proteomics, it is speculated that micro and nano-chip technology for proteomics are indeed on the horizon. … Thus, further investigations on functional protein analysis devices by micro and nanochip technology are still needed to make this a success. …
NAID 110006825852

BABA YOSHINOBU
International Symposium on Micro-Mechanical Engineering : ISMME 2003, 94-99, 2003-11-30
… In the post Human Genome sequencing era, further development of analytical technology for DNA is highly required for high-throughput screening of disease-causing gene from 3.2 Gbp human genome and high-speed analysis of genetic polymorphism, having ca. … We have been challenged to develop the novel technology for ultra-fast DNA analysis by the microfabricated chip-based integration of all processes required for human genome analysis. …
NAID 110002344851