WordNet

any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates
the commonest protein in muscle; a globulin that combines with actin to form actomyosin

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1. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing
2. 巣状分節性糸球体硬化症の疫学、分類、および病因 epidemiology classification and pathogenesis of focal segmental glomerulosclerosis
3. 心筋炎の病因および発症機序 etiology and pathogenesis of myocarditis
4. 肥大型心筋症：自然経過および予後 hypertrophic cardiomyopathy natural history and prognosis
5. 急性大動脈解離の臨床的特徴および診断 clinical features and diagnosis of acute aortic dissection

Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling.

Xie X, Chang X, Chen L, Huang K, Huang J, Wang S, Shen X, Liu P, Huang H.SourceLaboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Department of Pharmaceutical Engineering, Ocean College, Hainan University, Haikou 570228, China.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Dec 5;381(1-2):56-65. doi: 10.1016/j.mce.2013.07.019. Epub 2013 Jul 26.
The accumulation of glomerular extracellular matrix proteins, especially fibronectin (FN), is a critical pathological characteristic of diabetic renal fibrosis. Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of diabetic nephropathy (DN). RhoA/ROCK sign
PMID 23896433

cAMP signalling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho Kinase-MLC phosphatase signalling pathway.

Aburima A, Wraith KS, Raslan Z, Law R, Magwenzi S, Naseem KM.SourceCentre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull, Hull, United Kingdom.
Blood.Blood.2013 Oct 7. [Epub ahead of print]
Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet shape change through unknown mechanisms. Here we examined the effects of cAMP signaling on platelet contractile machinery. Prostaglandin E1 (PGE1) mediated inhibition of thrombin-stimulated shape change was accompanied by d
PMID 24100445

Hudson MB, Price SR.SourceDepartment of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address: mbhudso@emory.edu.
The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2013 Oct;45(10):2173-8. doi: 10.1016/j.biocel.2013.06.029. Epub 2013 Jul 6.
This review will discuss the existing literature that has examined the role of calcineurin (CnA) in the regulation of skeletal muscle mass in conditions associated with hypertrophic growth or atrophy. Muscle mass is determined by the balance between protein synthesis and degradation which is control
PMID 23838168

Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway

Takemoto Kenji,Ishihara Seiichiro,Mizutai Takeomi,Kawabata Kazushige,Haga Hisashi
PLOS ONE 10(3), e0117937, 2015-03-03
… For example, stretching induces phosphorylation of the myosin regulatory light chain (MRLC) via the RhoA/RhoA-associated protein kinase (ROCK) pathway, resulting in increased cellular tension. … Compressive loading induced activation of myosin phosphatase mediated via the dephosphorylation of myosin phosphatase targeting subunit 1 (Thr853). …
NAID 120005613567

New Trends in therapeutic strategies against ischemia/reperfusion injury; Postconditioning and pharmacological intervention in acute myocardial infarction

Shimada Megumi,Koyama Takashi,Baba Akiyasu,Kosugi Rie,Akaishi Makoto
Microvascular Reviews and Communications 7(1), 31a-31a, 2014
… A rat model of myocardial I-R injury was investigated by ligating the left descending coronary artery for 30 min and then reperfusing for 180 min. Continuous infusion of ANP (0.1 ug/kg/min) was started 5 min after the ligation and lasting for 175 min. Phosphorylation of the ROCK substrate protein myosin phosphatase targeting subunit (MYPT)-1 assessed by western blotting was used as a marker of ROCK activation. …
NAID 130004678487

The involvement of myosin regulatory light chain diphosphorylation in sustained vasoconstriction under pathophysiological conditions

Takeya Kosuke,Wang Xuemei,Sutherland Cindy,Kathol Iris,Loutzenhiser Kathy,Loutzenhiser Rodger D.,Walsh Michael P.
Journal of Smooth Muscle Research 50(0), 18-28, 2014
… publisherSmooth muscle contraction is activated primarily by phosphorylation at Ser19 of the regulatory light chain subunits (LC20) of myosin II, catalysed by Ca(2+)/calmodulin-dependent myosin light chain kinase. … Ca(2+)-independent contraction can be induced by inhibition of myosin light chain phosphatase, which correlates with diphosphorylation of LC20 at Ser19 and Thr18, catalysed by integrin-linked kinase (ILK) and zipper-interacting protein kinase (ZIPK). …
NAID 130003391243

リンク元	「ミオシンホスファターゼ」「myosin light-chain phosphatase」「ミオシン脱リン酸化酵素」
関連記事	「phosphatase」