Multisteric TRPV1 nocisensor: a target for analgesics.
Szolcsányi J, Sándor Z.SourceDepartment of Pharmacology and Pharmacotherapy, University of Pécs Medical School, H-7624 Pécs, Szigeti u. 12, Hungary. Electronic address: janos.szolcsanyi@aok.pte.hu.
Trends in pharmacological sciences.Trends Pharmacol Sci.2012 Dec;33(12):646-55. doi: 10.1016/j.tips.2012.09.002. Epub 2012 Oct 12.
Cloning of the transient receptor potential vanilloid type 1 (TRPV1), the heat-gated cation channel/capsaicin receptor expressed by sensory neurons, has opened the door for development of new types of analgesics that selectively act on nociceptors. Here we summarize mutagenetic evidence for selectiv
ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application.
Gyimesi G, Borsodi D, Sarankó H, Tordai H, Sarkadi B, Hegedűs T.SourceMembrane Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
Human mutation.Hum Mutat.2012 Nov;33(11):1547-56. doi: 10.1002/humu.22138. Epub 2012 Jul 11.
To overcome the pathological phenomena caused by altered function of ABC (ATP Binding Cassette) proteins, their mechanisms of action are extensively investigated, often involving the design of mutant constructs for experiments. Designing mutagenetic constructs, interpreting the result of mutagenetic
Tempol suppresses micronuclei formation in astrocytes of newborn rats exposed to 50-Hz, 10-mT electromagnetic fields under bleomycin administration.
Miyakoshi Y, Kajihara C, Shimizu H, Yanagisawa H.SourceDepartment of Public Health and Environmental Medicine, the Jikei University School of Medicine, Tokyo, Japan. miyakoshi@jikei.ac.jp
Mutation research.Mutat Res.2012 Aug 30;747(1):138-41. doi: 10.1016/j.mrgentox.2012.05.001. Epub 2012 May 14.
A number of epidemiological studies have suggested that exposure to environmental and occupational electromagnetic fields (EMFs) contribute to the induction of brain tumors. The aim of this study was to investigate the mutagenetic effects of co-exposure to 50-Hz, 10-mT EMFs and bleomycin (BLM) using