出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/26 11:14:57」(JST)
Muramyl dipeptide | |
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IUPAC name
(4R)-4-[ [(2S)-2-[ [(2R)-2-[(2R,5S)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid |
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Other names
Acetylmuramyl-Alanyl-Isoglutamine |
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Identifiers | |
CAS number | 53678-77-6 |
PubChem | 11620162 |
ChemSpider | 9794910 Y |
MeSH | Muramyl+dipeptide |
Jmol-3D images | Image 1 |
SMILES
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InChI
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Properties | |
Molecular formula | C19H32N4O11 |
Molar mass | 492.47758 |
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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Infobox references |
Muramyl dipeptide is a peptidoglycan constituent of both Gram positive and Gram negative bacteria. It is composed of N-acetylmuramic acid linked by its lactic acid moiety to the N-terminus of an L-alanine D-isoglutamine dipeptide.[1]
It can be recognized by the immune system as a PAMP (pathogen associated molecular pattern)and activate the NALP3 inflammasome which in turn leads to cytokine activation, especially IL-1α and IL-1β. [2]
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リンク元 | 「ムラミルジペプチド」「acetylmuramyl-alanyl-isoglutamine」「muramyldipeptide」 |
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