WordNet

having or involving or consisting of more than one part or entity or individual; "multiple birth"; "multiple ownership"; "made multiple copies of the speech"; "his multiple achievements in public life"; "her multiple personalities"; "a pineapple is a multiple fruit"
the product of a quantity by an integer; "36 is a multiple of 9"
having similarity in size, shape, and relative position of corresponding parts (同)symmetric
pathology in which fat accumulates in lipomas in the body

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多数の部分(要素)から成る,複合の,複式の / 倍数

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 16:20:41」(JST)

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Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.^[1] In 1993, a genetic defect within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C.^[2] This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.^[3]^[4]^[5]

Although this condition is benign, it can sometimes be very painful depending on location of said lipoma many patients concerned with cosmesis also seek removal of individual tumors. Treatment can include simple excision, endoscopic removal, or liposuction.^[6]

Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease),Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis,^[7] and familial angiolipomatosis.

References

^ Familial multiple lipomatosis
^ Schoenmakers, EF; Wanschura, S; Mols, R; Bullerdiek, J; Van Den Berghe, H; Van De Ven, WJ (1995). "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours". Nature genetics 10 (4): 436–44. doi:10.1038/ng0895-436. PMID 7670494.
^ Weiss, SW (1996). "Lipomatous tumors". Monographs in pathology 38: 207–39. PMID 8744279.
^ Gologorsky, Y; Gologorsky, D; Yarygina, AS; Surti, U; Zirwas, MJ (2007). "Familial multiple lipomatosis: Report of a new family". Cutis; cutaneous medicine for the practitioner 79 (3): 227–32. PMID 17674589.
^ http://www.genome.jp/dbget-bin/www_bget?omim+151900 Lipomatosis, Familial Multiple Lipomatosis, FML
^ Familial multiple lipomatosis
^ https://www.biomedcentral.com/1471-2253/14/70 Multiple Epidural Steroid Injections and Epidural Lipomatosis

External links

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