WordNet

having or involving or consisting of more than one part or entity or individual; "multiple birth"; "multiple ownership"; "made multiple copies of the speech"; "his multiple achievements in public life"; "her multiple personalities"; "a pineapple is a multiple fruit"
the product of a quantity by an integer; "36 is a multiple of 9"
(genetics) either of a pair (or series) of alternative forms of a gene that can occupy the same locus on a particular chromosome and that control the same character; "some alleles are dominant over others" (同)allelomorph

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Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.

Nimptsch K1, Aleksandrova K, Boeing H, Janke J, Lee YA, Jenab M, Bueno-de-Mesquita HB, Jansen EH, Tsilidis KK, Trichopoulou A, Weiderpass E, Wu C, Overvad K, Tjønneland A, Boutron-Ruault MC, Dossus L, Racine A, Kaaks R, Canzian F, Lagiou P, Trichopoulos D, Palli D, Agnoli C, Tumino R, Vineis P, Panico S, Johansson A, Van Guelpen B, Khaw KT, Wareham N, Peeters PH, Quirós JR, Venceslá García A, Molina-Montes E, Dorronsoro M, Chirlaque MD, Barricarte Gurrea A, Key TJ, Duarte-Salles T, Stepien M, Gunter MJ, Riboli E, Pischon T.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Mar 1;136(5):1181-92. doi: 10.1002/ijc.29086. Epub 2014 Jul 28.
High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relations
PMID 25043606

RANK/RANKL/OPG pathway: Genetic associations with stress fracture period prevalence in elite athletes.

Varley I1, Hughes DC2, Greeves JP3, Stellingwerff T4, Ranson C5, Fraser WD6, Sale C7.
Bone.Bone.2015 Feb;71:131-6. doi: 10.1016/j.bone.2014.10.004. Epub 2014 Oct 29.
CONTEXT: The RANK/RANKL/OPG signalling pathway is important in the regulation of bone turnover, with single nucleotide polymorphisms (SNPs) in genes within this pathway associated with bone phenotypic adaptations.OBJECTIVE: To determine whether four SNPs associated with genes in the RANK/RANKL/OPG s
PMID 25464125

Evidence of hormone resistance in a pseudo-pseudohypoparathyroidism patient with a novel paternal mutation in GNAS.

Turan S1, Thiele S2, Tafaj O3, Brix B2, Atay Z4, Abali S4, Haliloglu B4, Bereket A4, Bastepe M5.
Bone.Bone.2015 Feb;71:53-7. doi: 10.1016/j.bone.2014.10.006. Epub 2014 Oct 18.
CONTEXT: Loss-of-function GNAS mutations lead to hormone resistance and Albright's hereditary osteodystrophy (AHO) when maternally inherited, i.e. pseudohypoparathyroidism-Ia (PHPIa), but cause AHO alone when located on the paternal allele, i.e. pseudoPHP (PPHP).OBJECTIVE: We aimed to establish the
PMID 25464124

Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population

Migita Kiyoshi,Nakamura Minoru,Abiru Seigo,Jiuchi Yuka,Nagaoka Shinya,Komori Atsumasa,Hashimoto Satoru,Bekki Shigemune,Yamasaki Kazumi,Komatsu Tatsuji,Shimada Masaaki,Kouno Hiroshi,Hijioka Taizo,Kohjima Motoyuki,Nakamuta Makoto,Kato Michio,Yoshizawa Kaname,Ohta Hajime,Nakamura Yoko,Takezaki Eiichi,Nishimura Hideo,Sato Takeaki,Ario Keisuke,Hirashima Noboru,Oohara Yukio,Naganuma Atsushi,Muro Toyokichi,Sakai Hironori,Mita Eiji,Sugi Kazuhiro,Yamashita Haruhiro,Makita Fujio,Yatsuhashi Hiroshi,Ishibashi Hiromi,Yasunami Michio
PLoS ONE 8(8), e71382, 2013-08-22
… Background/Aims:Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. … The STAT4 rs7574865T allele conferred risk for type-1 autoimmune hepatitis (OR = 1.61, 95% CI = 1.23-2.11; … P = 0.001), and patients without accompanying autoimmune diseases exhibited an association with the rs7574865T allele (OR = 1.50, 95%CI = 1.13-1.99; …
NAID 120005328270

Kato M.,Atsumi T.,Oku K.,Amengual O.,Nakagawa H.,Fujieda Y.,Otomo K.,Horita T.,Yasuda S.,Koike T.
Lupus 22(8), 761-771, 2013-07
… Background CD36, known as a scavenger receptor, is a transmembrane glycoprotein expressed on monocytes, platelets and endothelial cells, recognizes multiple ligands, including phosphatidylserine, and regulates atherogenesis and thrombosis. … Results Minor allele carrier of rs3765187 was less frequent in patients with APS (3.8% p=0.032), but not in patients with SLE in the absence of APS (7.9% p=0.32), compared with healthy subjects (10.2%). …
NAID 120005372328

Naka Izumi,Ohashi Jun,Kimura Ryosuke,Inaoka Tsukasa,Matsumura Yasuhiro,大橋順
Lipids in health and disease 12, 110, 2013-07
… previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.MethodsTo investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and …
NAID 120005323062