- 関
- mucosal immune response
WordNet
- (medicine) the condition in which an organism can resist disease (同)resistance
- the quality of being unaffected by something; "immunity to criticism"
- of or relating to mucous membranes
PrepTutorEJDIC
- 〈U〉(病気に対する)免疫《+『from』(『to, against』)+『名』》 / (義務・税などの)免除《+『from』(『to, against』)+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/10 08:37:50」(JST)
[Wiki en表示]
Mucosal immunology is the portion of the immune system which provides protection to an organism's various mucous membranes from invasion by potentially pathogenic microbes. It provides three main functions:[1] protecting the mucous membrane against infection, preventing the uptake of antigens, microorganisms, and other foreign materials, and moderating the organism's immune response to that material.
At birth, the neonate's mucosal immune system is relatively undeveloped, but the colonization of intestinal flora accelerates its development.
Because of its front-line status within the immune system, the mucosal immune system is being investigated for use in vaccines for various afflictions,[2] including AIDS[3][4][5] and allergies.[6]
References
- ^ Holmgren, Jan; Czerkinsky, Cecil (2005). "Mucosal immunity and vaccines". Nature Medicine 11 (4 Suppl): S45–53. doi:10.1038/nm1213. PMID 15812489.
- ^ Mucosal Immunity and Vaccines, August 2003
- ^ Bourinbaiar, Aldar S.; Metadilogkul, Orapun; Jirathitikal, Vichai (2003). "Mucosal AIDS Vaccines". Viral Immunology 16 (4): 427–45. doi:10.1089/088282403771926274. PMID 14733732.
- ^ Simerska, Pavla; Moyle, Peter M.; Olive, Colleen; Toth, Istvan (2009). "Oral Vaccine Delivery - New Strategies and Technologies". Current Drug Delivery 6 (4): 347–58. doi:10.2174/156720109789000537. PMID 19534712.
- ^ Silin, Dmytro S.; Lyubomska, Oksana V.; Jirathitikal, Vichai; Bourinbaiar, Aldar S. (2007). "Oral vaccination: where we are?". Expert Opinion on Drug Delivery 4 (4): 323–40. doi:10.1517/17425247.4.4.323. PMID 17683247.
- ^ Wild, C.; Wallner, M.; Hufnagl, K.; Fuchs, H.; Hoffmann-Sommergruber, K.; Breiteneder, H.; Scheiner, O.; Ferreira, F.; Wiedermann, U. (2007). "A recombinant allergen chimer as novel mucosal vaccine candidate for prevention of multi-sensitivities". Allergy 62 (1): 33–41. doi:10.1111/j.1398-9995.2006.01245.x. PMID 17156339.
See also
UpToDate Contents
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English Journal
- Activation of B cells by a dendritic cell-targeted oral vaccine.
- Sahay B, Owen JL, Yang T, Zadeh M, Lightfoot YL, Ge JW, Mohamadzadeh M1.Author information 1Department of Infectious Diseases & Pathology, Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Florida, 2015 SW16th Ave, Building 1017, Room: V3-149, Gainesville, FL 32608, USA. m.zadeh@ufl.edu.AbstractProduction of long-lived, high affinity humoral immunity is an essential characteristic of successful vaccination and requires cognate interactions between T and B cells in germinal centers. Within germinal centers, specialized T follicular helper cells assist B cells and regulate the antibody response by mediating the differentiation of B cells into memory or plasma cells after exposure to T cell-dependent antigens. It is now appreciated that local immune responses are also essential for protection against infectious diseases that gain entry to the host by the mucosal route; therefore, targeting the mucosal compartments is the optimum strategy to induce protective immunity. However, because the gastrointestinal mucosae are exposed to large amounts of environmental and dietary antigens on a daily basis, immune regulatory mechanisms exist to favor tolerance and discourage autoimmunity at these sites. Thus, mucosal vaccination strategies must ensure that the immunogen is efficiently taken up by the antigen presenting cells, and that the vaccine is capable of activating humoral and cellular immunity, while avoiding the induction of tolerance. Despite significant progress in mucosal vaccination, this potent platform for immunotherapy and disease prevention must be further explored and refined. Here we discuss recent progress in the understanding of the role of different phenotypes of B cells in the development of an efficacious mucosal vaccine against infectious disease.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Nov;14(10):867-77.
- Production of long-lived, high affinity humoral immunity is an essential characteristic of successful vaccination and requires cognate interactions between T and B cells in germinal centers. Within germinal centers, specialized T follicular helper cells assist B cells and regulate the antibody respo
- PMID 24372255
- The interplay between HPV and host immunity in head and neck squamous cell carcinoma.
- Andersen AS1, Koldjaer Sølling AS, Ovesen T, Rusan M.Author information 1Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark.AbstractPersistent infection with human papillomavirus (HPV) type 16 is a major risk factor for the development of head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal squamous cell carcinoma (OPSCC). The oropharyngeal epithelium differs from the mucosal epithelium at other commonly HPV16-infected sites (i.e., cervix and anogenital region) in that it is juxtaposed with the underlying lymphatic tissue, serving a key immunologic function in the surveillance of inhaled and ingested pathogens. Therefore, the natural history of infection and immune response to HPV at this site may differ from that at other anatomic locations. This review summarizes the literature concerning the adaptive immune response against HPV in the context of HNSCC, with a focus on the T-cell response. Recent studies have shown that a broad repertoire of tumor-infiltrating HPV-specific T-cells are found in nearly all patients with HPV-positive tumors. A systemic response is found in only a proportion of these. Furthermore, the local response is more frequent in OPSCC patients than in cervical cancer patients and HPV-negative OPSCC patients. Despite this, tumor persistence may be facilitated by abnormalities in antigen processing, a skewed T-helper cell response, and an increased local prevalence of T-regulatory cells. Nonetheless, the immunologic profile of HPV-positive vs. HPV-negative HNSCC is associated with a significantly better outcome, and the HPV-specific immune response is suggested to play a role in the significantly better response to therapy of HPV-positive patients. Immunoprofiling may prove a valuable prognostic tool, and immunotherapy trials targeting HPV are underway, providing hope for decreasing treatment-related toxicity.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jun 15;134(12):2755-63. doi: 10.1002/ijc.28411. Epub 2013 Aug 29.
- Persistent infection with human papillomavirus (HPV) type 16 is a major risk factor for the development of head and neck squamous cell carcinoma (HNSCC), in particular oropharyngeal squamous cell carcinoma (OPSCC). The oropharyngeal epithelium differs from the mucosal epithelium at other commonly HP
- PMID 23913554
- l-Rhamnose-binding lectins (RBLs) in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues.
- Thongda W1, Li C1, Luo Y1, Beck BH2, Peatman E3.Author information 1School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL 36849, USA.2United States Department of Agriculture, Agricultural Research Service, Stuttgart National Aquaculture Research Center, Stuttgart, AR 72160, USA.3School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL 36849, USA. Electronic address: peatmer@auburn.edu.AbstractRhamnose-binding lectins (RBLs) have recently emerged as important molecules in the context of innate immunity in teleost fishes. Previously, using RNA-seq technology, we observed marked up-regulation of a RBL in channel catfish (Ictalurus punctatus) gill following a challenge with the bacterial pathogen Flavobacterium columnare. Furthermore, the magnitude of RBL up-regulation positively correlated with disease susceptibility. Moving forward from these findings, we wished to more broadly understand RBL function, diversity, and expression kinetics in channel catfish. Therefore, in the present study we characterized the RBL gene family present in select channel catfish tissues and profiled family member expression after challenge with two different Gram-negative bacterial pathogens. Here, six RBLs were identified from channel catfish and were designated IpRBL1a, IpRBL1b, IpRBL1c, IpRBL3a, IpRBL3b, and IpRBL5a. These RBLs contained carbohydrate recognition domains (CRD) ranging from one to three domains and each CRD contained the conserved motifs of -YGR- and -DPC-. Despite a level of structural conservation, the catfish RBLs showed low full-length identity with RBLs from outside the order Siluriformes. IpRBL expression after bacterial infection varied depending on both pathogen and tissue type, suggesting that IpRBLs may exert disparate functions or exhibit distinct tissue-selective roles in the host immune response to bacterial pathogens.
- Developmental and comparative immunology.Dev Comp Immunol.2014 Jun;44(2):320-31. doi: 10.1016/j.dci.2014.01.018. Epub 2014 Jan 27.
- Rhamnose-binding lectins (RBLs) have recently emerged as important molecules in the context of innate immunity in teleost fishes. Previously, using RNA-seq technology, we observed marked up-regulation of a RBL in channel catfish (Ictalurus punctatus) gill following a challenge with the bacterial pat
- PMID 24480296
Japanese Journal
- 炎症性腸疾患における腸内細菌叢と粘膜免疫の異常 (第1土曜特集 粘膜免疫Update) -- (粘膜免疫と疾患)
- 寄生虫感染と粘膜免疫 (第1土曜特集 粘膜免疫Update) -- (粘膜免疫と微生物・感染)
- 腸上皮のPaneth細胞が担う自然免疫・粘膜免疫 (第1土曜特集 粘膜免疫Update) -- (基礎)
Related Links
- Review Nature Medicine 11, S45 - S53 (2005) Published online: ; | doi:10.1038/nm1213 Mucosal immunity and vaccines Jan Holmgren 1 & Cecil Czerkinsky 2 1 Department of Medical Microbiology & Immunology and ...
- Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal ...
★リンクテーブル★
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- 英
- mucosal immunity
- 関
- 粘膜免疫応答
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- 関
- mucosal immunity
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- 関
- mucosa、mucosae、mucous、mucous membrane