morbillivirus

モルビリウイルス、モリビリウイルス

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/09/19 02:42:02」(JST)

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Morbillivirus
Measles morbillivirus electron micrograph
Virus classification
(unranked):	Virus
Realm:	Riboviria
Phylum:	Negarnaviricota
Class:	Monjiviricetes
Order:	Mononegavirales
Family:	Paramyxoviridae
Subfamily:	Orthoparamyxovirinae
Genus:	Morbillivirus
Type species
Measles morbillivirus
Species
Canine morbillivirus Cetacean morbillivirus Feline morbillivirus Feline morbillivirus 2 Measles morbillivirus Phocine morbillivirus Rinderpest morbillivirus Small ruminant morbillivirus

Morbillivirus is a genus of viruses in the order Mononegavirales, in the family Paramyxoviridae. Humans, dogs, cats, cattle, seals, and cetaceans serve as natural hosts. This genus currently included seven species. Diseases in humans associated with viruses classified in this genus include measles: fever, and rash; in animals, they include acute febrile respiratory tract infection.

Taxonomy

Genus Morbillivirus: species and their viruses

Genus	Species	Virus (Abbreviation)
Morbillivirus	Canine morbillivirus	Canine distemper virus (CDV)
	Cetacean morbillivirus	Cetacean morbillivirus (CeMV)
	Feline morbillivirus	Feline morbillivirus (FeMV)
	Feline morbillivirus 2	Feline morbillivirus 2 (FeMV 2)
	Measles morbillivirus*	Measles virus (MeV)
	Ovine rinderpest	Peste-des-petits-ruminants virus (PPRV)
	Phocine morbillivirus	Phocine distemper virus (PDV)
	Rinderpest morbillivirus	Rinderpest virus (RPV)

Table legend: "*" denotes type species

Structure

Morbillivirions are enveloped, with spherical geometries. Their diameter is around 150 nm. Genomes are linear, around 15-16 kb in length. The genome codes for eight proteins.

Genus	Structure	Symmetry	Capsid	Genomic arrangement	Genomic segmentation
Morbillivirus	Spherical		Enveloped	Linear	Monopartite

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaching to host cell. Replication follows the negative-stranded RNA virus replication model. Negative-stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by budding. Humans, cattle, dogs, cats, and cetaceans serve as the natural hosts. Transmission routes are respiratory.

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
Morbillivirus	Humans, dogs, cats, cetaceans	None	Glycoprotein	Budding	Cytoplasm	Cytoplasm	Aerosols

External links

• Viralzone: Morbillivirus
• ICTV
• Virus Pathogen Database and Analysis Resource (ViPR): Paramyxoviridae

UpToDate Contents

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• 1. 基礎疾患の状態、環境曝露、およびその他の原因による二次性免疫不全症 secondary immunodeficiency due to underlying disease states environmental exposures and miscellaneous causes

English Journal

• Quantitative PCR detection of feline morbillivirus in cat urine samples.

• Furuya T1, Wachi A, Sassa Y, Omatsu T, Nagai M, Fukushima R, Shibutani M, Yamaguchi T, Uematsu Y, Shirota K, Mizutani T.
• The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2016 Jan 1;77(12):1701-3. doi: 10.1292/jvms.15-0112. Epub 2015 Jul 26.
• Feline morbillivirus (FmoPV) is a new virus species and its detection is important, since correlation has been reported between FmoPV virus infection and tubulointerstitial nephritis in cats. Here, we report a real-time reverse transcription (RT)-PCR system that can detect the FmoPV L-gene sequence
• PMID 26227478

• Specific detection of peste des petits ruminants virus antibodies in sheep and goat sera by the luciferase immunoprecipitation system.

• Berguido FJ1, Bodjo SC2, Loitsch A3, Diallo A4.
• Journal of virological methods.J Virol Methods.2016 Jan;227:40-6. doi: 10.1016/j.jviromet.2015.10.008. Epub 2015 Oct 23.
• Peste des petits ruminants (PPR) is a contagious and often fatal transboundary animal disease affecting mostly sheep, goats and wild small ruminants. This disease is endemic in most of Africa, the Middle, Near East, and large parts of Asia. The causal agent is peste des petits ruminants virus (PPRV)
• PMID 26506137

• Efficient generation of vesicular stomatitis virus (VSV)-pseudotypes bearing morbilliviral glycoproteins and their use in quantifying virus neutralising antibodies.

• Logan N1, McMonagle E2, Drew AA3, Takahashi E4, McDonald M5, Baron MD6, Gilbert M7, Cleaveland S8, Haydon DT9, Hosie MJ10, Willett BJ11.
• Vaccine.Vaccine.2015 Dec 17. pii: S0264-410X(15)01778-8. doi: 10.1016/j.vaccine.2015.12.006. [Epub ahead of print]
• Morbillivirus neutralising antibodies are traditionally measured using either plaque reduction neutralisation tests (PRNTs) or live virus microneutralisation tests (micro-NTs). While both test formats provide a reliable assessment of the strength and specificity of the humoral response, they are res
• PMID 26706278

Japanese Journal

• ネコモルビリウイルスの発見と現状について

• ウイルス = Virus 66(2), 147-154, 2016-12
• NAID 40021077519

• Rapid detection of feline morbillivirus by a reverse transcription loop-mediated isothermal amplification

• Journal of Veterinary Medical Science 78(1), 105-108, 2016
• NAID 130005121592

• フラグメント分子軌道法の地球生態系解析への応用 : モルビリウイルスヘマグルチニンと受容体の相互作用の解析

• Annual report of the earth simulator, 131-135, 2015-04
• NAID 40020825089

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