monoblast

　

WordNet

1. a large immature monocyte normally found in bone marrow

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/29 03:36:46」(JST)

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Monoblast
Monoblast
Code	TH H2.00.04.3.08002

Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages.

Structure

A typical monoblast is about 12 to 20 µm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure. One to four nucleoli are usually visible. The nucleus can be central or eccentric and it can show evidence of indentation or folding. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone.

Maturation

The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte -> monocyte-> macrophage.

Additional images

• Blood cell lineage

• Hematopoiesis

See also

• Monocyte
• Macrophage
• Agranulocyte
• White blood cell

English Journal

• Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis.

• Funakubo N1,2,3, Xu X1,2, Kukita T2, Nakamura S3, Miyamoto H1, Kukita A1.
• Journal of cellular physiology.J Cell Physiol.2018 Apr;233(4):3105-3118. doi: 10.1002/jcp.26147. Epub 2017 Sep 20.
• PMID 28802000

• Recombinant latcripin 11 of Lentinula edodes C91-3 suppresses the proliferation of various cancer cells.

• Gao Y1, Padhiar AA2, Wang J3, Zhang W2, Zhong M2, Liu B2, Kang Z4, Wang X2, Li X2, Huang M5.
• Gene.Gene.2018 Feb 5;642:212-219. doi: 10.1016/j.gene.2017.10.080. Epub 2017 Oct 28.
• PMID 29111208

• RNA-Seq revealed ATF3-regulated inflammation induced by silica.

• Chan JYW1, Tsui JCC2, Law PTW3, So WKW4, Leung DYP4, Sham MMK5, Tsui SKW6, Chan CWH7.
• Toxicology.Toxicology.2018 Jan 15;393:34-41. doi: 10.1016/j.tox.2017.11.001. Epub 2017 Nov 2.
• PMID 29102675

Japanese Journal

• Progesterone Metabolism in Human Leukemic Monoblast U937 Cells

• SUZUKI TAKASHI,MURRY BARBARA A.,DARNEL ANDREW D.,SASANO HIRONOBU
• Endocrine journal 49(5), 539-546, 2002-10-01
• NAID 50000681785

• The Ca^<2+>-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells

• KRAMER R. M.
• J. Biol. Chem. 266, 5268-5272, 1991
• NAID 80005844539

• Chronic myelomonocytic leukemia with first manifestation of the submandibular swelling; A report of case.

• 浜田 陽一郎,明島 淳吾,石倉 信造,領家 和男,濱田 驍
• 日本口腔外科学会雑誌 37(2), 474-480, 1991
• … Bone marrow biopsy specimens showed hypercellularity of myeloblasts and monoblast. …
• NAID 130001781615

Related Links

• Monoblast | definition of monoblast by Medical dictionary

monoblast [mon´o-blast] the earliest precursor in the monocytic series, which develops into the promonocyte. mon·o·blast (mon'ō-blast), An immature cell that develops into a monocyte. [mono- + G. blastos, germ] monoblast /mono ...

• Monoblast - definition of monoblast by The Free Dictionary

Thesaurus Antonyms Related Words Synonyms Legend: Noun 1. monoblast - a large immature monocyte normally found in bone marrow monocyte - a type of granular leukocyte that ... In general, the cells of diffuse large B-cell ...

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拡張検索	「monoblastic」「acute monoblastic leukemia」

「monoblastic」

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monoblast

「acute monoblastic leukemia」

　　[★] 急性単芽球性白血病