molindone

モリンドン 　

WordNet

1. antipsychotic drug (trade name Moban) used in the treatment of schizophrenia (同)Moban

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/27 15:21:42」(JST)

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Molindone

Systematic (IUPAC) name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)- 1,5,6,7-tetrahydro-4H-indol-4-one
Clinical data
Trade names	Moban
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682238
Pregnancy category	C
Legal status	℞ (Prescription only)
Routes of administration	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	1.5 hours
Excretion	Minor, renal and fecal
Identifiers
CAS Registry Number	7416-34-4 Y
ATC code	N05AE02
PubChem	CID 23897
IUPHAR ligand	207
DrugBank	DB01618 N
ChemSpider	22342 Y
UNII	RT3Y3QMF8N Y
KEGG	D08226 Y
ChEMBL	CHEMBL460 Y
Chemical data
Formula	C16H24N2O2
Molecular mass	276.374 g/mol
SMILES O=C2c1c(c(nc1CCC2CN3CCOCC3)C)CC
InChI InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3  Y Key:KLPWJLBORRMFGK-UHFFFAOYSA-N  Y
N (what is this?)  (verify)

Molindone (Moban) is a therapeutic antipsychotic, used in the treatment of schizophrenia. It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken orally.

It is sometimes described as a typical antipsychotic, and sometimes described as an atypical antipsychotic.

Molindone was discontinued by its sole supplier, Endo Pharmaceuticals, on January 13, 2010.

Adverse effects

Main article: Typical antipsychotic

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.

See also

• Losindole
• Piquindone

References

UpToDate Contents

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• 1. 成人における肥満：病因および自然経過 obesity in adults etiology and natural history

English Journal

• Could repetitive transcranial magnetic stimulation improve neurocognition in early-onset schizophrenia spectrum disorders?

• Croarkin PE, Daskalakis ZJ.
• Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2012 Sep;51(9):949-51. doi: 10.1016/j.jaac.2012.05.012.
• PMID 22917209

• Neurocognitive outcomes in the Treatment of Early-Onset Schizophrenia Spectrum Disorders study.

• Frazier JA, Giuliano AJ, Johnson JL, Yakutis L, Youngstrom EA, Breiger D, Sikich L, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA, Hooper SR.SourceUniversity of Massachusetts Medical School, Worcester, MA 01605, USA. Jean.Frazier@umassmed.edu
• Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2012 May;51(5):496-505. doi: 10.1016/j.jaac.2012.02.001. Epub 2012 Mar 13.
• OBJECTIVE: To assess neurocognitive outcomes following antipsychotic intervention in youth enrolled in the National Institute of Mental Health (NIMH)-funded Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS).METHOD: Neurocognitive functioning of youth (ages 8 to 19 years) with schizop
• PMID 22525956

• The voices go, but the song remains the same: how can we rescue cognition in early-onset schizophrenia?

• Bachman P, Jalbrzikowski M, Bearden CE.
• Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2012 May;51(5):464-6. doi: 10.1016/j.jaac.2012.02.002.
• PMID 22525952

Japanese Journal

• D-Cycloserine adjuvant therapy to molindone in the treatment of schizophrenia

• Clin Neuropharmacol 19, 444-450, 1996
• NAID 80009205492

Related Pictures

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★リンクテーブル★

リンク元

「モリンドン」

「モリンドン」

　　[★]

英

molindone

化

塩酸モリンドン molindone hydrochloride

商

Moban

関

抗精神病薬