モガムリズマブ
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/10 20:58:39」(JST)
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Mogamulizumab ?
Monoclonal antibody |
Type |
Whole antibody |
Source |
Humanized (from mouse) |
Target |
CCR4 |
Clinical data |
Trade names |
Poteligeo |
Legal status |
? |
Routes |
IV |
Identifiers |
CAS number |
1159266-37-1 N |
ATC code |
None |
Chemical data |
Formula |
C6520H10072N1736O2020S42 |
Mol. mass |
146.44 kDa |
N (what is this?) (verify) |
Mogamulizumab (USAN; trade name Poteligeo) is a humanized monoclonal antibody targeting CC chemokine receptor 4 (CCR4). It has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukemia/lymphoma.[1]
Mogamulizumab was developed by Kyowa Hakko Kirin Co., Ltd.[2] It has also been licensed to Amgen for development as a therapy for Asthma.[3]
References[edit]
- ^ Subramaniam, J; Whiteside G, McKeage K, Croxtall J (18 June 2012). "Mogamulizumab: First Global Approval". Drugs 72 (9): 1293–1298. doi:10.2165/11631090-000000000-00000. Retrieved 10 September 2012.
- ^ "Statement On A Nonproprietary Name Adopted By The USAN Council: Mogamulizumab". American Medical Association.
- ^ "Kyowa Hakko Kirin R&D Pipeline". Kyowa Hakko Kirin. Retrieved 10 September 2012.
UpToDate Contents
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English Journal
- Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.
- Sugata K1,2, Yasunaga J1, Miura M1, Akari H3, Utsunomiya A4, Nosaka K5, Watanabe Y6, Suzushima H6, Koh KR7, Nakagawa M8, Kohara M9, Matsuoka M1.
- Scientific reports.Sci Rep.2016 Jun 2;6:27150. doi: 10.1038/srep27150.
- Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia and inflammatory diseases. Because anti-HTLV-1 immune responses are critical for suppressing infected cells, enhancing cellular immunity is beneficial for the treatment of HTLV-1-associated diseases. Using simian T-cell leukemi
- PMID 27250643
- Mogamulizumab for the treatment of cutaneous T-cell lymphoma: recent advances and clinical potential.
- Duvic M1, Evans M2, Wang C3.
- Therapeutic advances in hematology.Ther Adv Hematol.2016 Jun;7(3):171-4. doi: 10.1177/2040620716636541. Epub 2016 Mar 17.
- Mogamulizumab (KW-0761) is a humanized immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that targets CC chemokine receptor 4 (CCR4). It has shown promising therapeutic potential in phase I and II clinical trials and is currently being investigated for efficacy in treating cutaneous T-cell lymphoma
- PMID 27247757
- Anti-CCR4 Monoclonal Antibody Mogamulizumab Followed by the GDP (Gemcitabine, Dexamethasone and Cisplatin) Regimen in Primary Refractory Angioimmunoblastic T-Cell Lymphoma.
- Kato H1, Yamamoto K, Higuchi Y, Yamamoto H, Saito T, Taji H, Yatabe Y, Nakamura S, Kinoshita T.
- Chemotherapy.Chemotherapy.2016 May 27;62(1):19-22. [Epub ahead of print]
- There are few effective options for salvage therapy in elderly patients with relapsed or refractory angioimmunoblastic T-cell lymphoma (AITL). The anti-CCR4 antibody mogamulizumab works via antibody-dependent cytotoxic activity, reduces regulatory T cells, and evokes antitumor immunity in cancer pat
- PMID 27226129
Japanese Journal
- 成人T細胞性白血病・リンパ腫に対する臍帯血移植の現状と課題
- 症例 モガムリズマブ治療中の成人T細胞白血病リンパ腫患者に生じたSweet病様皮疹の1例
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