moban

同

molindone hydrochloride

WordNet

1. a disorderly crowd of people (同)rabble, rout

PrepTutorEJDIC

1. 〈C〉(無秩序な)『群衆』,暴徒,やじ馬 / 〈C〉(一般に,人・動物・物の)群れ,集まり《+『of』+『名』》 / 《the ~》大衆,民衆(the masses) / 《話》(盗賊・ギャングなどの)一団,一味 / …‘の'回りに熱狂して集まる;…‘に'大勢で押し寄せる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/15 05:54:55」(JST)

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Molindone

Systematic (IUPAC) name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)- 1,5,6,7-tetrahydro-4H-indol-4-one
Clinical data
Trade names	Moban
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682238
Pregnancy category	C
Routes of administration	Oral
Legal status	℞ (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	1.5 hours
Excretion	Minor, renal and fecal
Identifiers
CAS Number	7416-34-4 Y
ATC code	N05AE02 (WHO)
PubChem	CID 23897
IUPHAR/BPS	207
DrugBank	DB01618 N
ChemSpider	22342 Y
UNII	RT3Y3QMF8N Y
KEGG	D08226 Y
ChEMBL	CHEMBL460 Y
Chemical data
Formula	C16H24N2O2
Molar mass	276.374 g/mol
SMILES O=C2c1c(c(nc1CCC2CN3CCOCC3)C)CC
InChI InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3 Y Key:KLPWJLBORRMFGK-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Molindone (Moban) is a therapeutic antipsychotic, used in the treatment of schizophrenia. It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken orally.

It is sometimes described as a typical antipsychotic, and sometimes described as an atypical antipsychotic.

Molindone was discontinued by its sole supplier, Endo Pharmaceuticals, on January 13, 2010.

Adverse effects

Main article: Typical antipsychotic

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.

Synthesis

Molindone synthesis: SCHOEN KARL, J PACHTER IRWIN; BE 670798  (1965 to Endo Lab).

Condensation of oximinoketone 2 (from nitrosation of 3-pentanone), with 1,3-cyclohexanedione (1) in the presence of zinc and acetic acid leads directly to the partly reduced indole derivative 6. The transformation may be rationalized by assuming as the first step, reduction of 2 to the corresponding α-aminoketone. Conjugate addition of the amine to 1 followed by elimination of hydroxide (as water) would give ene-aminoketone 3. This enamine may be assumed to be in tautomeric equilibrium with imine 4. Aldol condensation of the side chain carbonyl group with the doubly activated ring methylene would then result in cyclization to pyrrole 5; simple tautomeric transformation would then give the observed product. Mannich reaction of 6 with formaldehyde and morpholine gives the tranquilizer molindone (7).

See also

• Losindole
• Piquindone

References

UpToDate Contents

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• 1. 成人における肥満：病因および自然経過 obesity in adults etiology and natural history

English Journal

• A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia.

• Harvey RC1, James AC2, Shields GE3.
• CNS drugs.CNS Drugs.2016 Jan;30(1):27-39. doi: 10.1007/s40263-015-0308-1.
• INTRODUCTION: Early-onset schizophrenia (EOS) is a serious debilitating disorder with considerable morbidity and a reduced life expectancy; therefore, early diagnosis and effective treatments are particularly important. Negative symptoms are more prominent in adolescents and children (compared with
• PMID 26801655

• Reversibility of dopamine receptor antagonist-induced hyperprolactinemia and associated histological changes in Tg RasH2 wild-type mice.

• Krishna G1, Ganiger S2, Kannan K3, Gopalakrishnan G4, Goel S5.
• Reproductive toxicology (Elmsford, N.Y.).Reprod Toxicol.2015 Dec;58:73-8. doi: 10.1016/j.reprotox.2015.08.006. Epub 2015 Aug 29.
• The purpose of this study was to better understand the biological effects of increased prolactin levels induced in mice by dopamine D2 receptor antagonist molindone treatment. Toxicokinetics, prolactin levels, and reproductive tissue histology were evaluated in Tg rasH2 wild-type mice treated orally
• PMID 26327279

• Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials.

• Jensen KG1, Juul K2, Fink-Jensen A3, Correll CU4, Pagsberg AK5.
• Journal of the American Academy of Child and Adolescent Psychiatry.J Am Acad Child Adolesc Psychiatry.2015 Jan;54(1):25-36. doi: 10.1016/j.jaac.2014.10.002. Epub 2014 Oct 16.
• OBJECTIVE: To evaluate the effect of antipsychotics on the corrected QT (QTc) interval in youth.METHOD: We searched PubMed (http://www.ncbi.nlm.nih.gov/pubmed) for randomized or open clinical trials of antipsychotics in youth <18 years with QTc data, meta-analyzing the results. Meta-regression a
• PMID 25524787

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