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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/13 10:25:29」(JST)

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Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971.^[1] It is a natural product, first isolated from the mould Eupenicillium brefeldianum. Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases. MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division. Thus, MZB has less toxicity than azathioprine, another immunosuppressant used for some of the same diseases.

References[edit]

^ Hiroaki Ishikawa (1999). "Mizoribine and Mycophenolate Mofetil". Current Medicinal Chemistry (Bentham Science) 6 (7): 575–597. PMID 10390602.

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Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases. MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division. Thus, MZB has less toxicity than azathioprine, another immunosuppressant used for some of the same diseases.

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1. 小児における特発性ネフローゼ症候群の治療 treatment of idiopathic nephrotic syndrome in children
2. 難治性の尋常性天疱瘡および落葉状天疱瘡のマネージメント management of refractory pemphigus vulgaris and pemphigus foliaceus
3. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome

English Journal

Ulcerative colitis associated with nephrotic syndrome after treatment with mesalazine developed into rectal carcinoma: a case study.

Sameshima S1, Koketsu S2, Okuyama T2, Kubota Y2, Ono Y3, Noie T2, Oya M2.
World journal of surgical oncology.World J Surg Oncol.2016 Jul 22;14(1):192. doi: 10.1186/s12957-016-0950-1.
BACKGROUND: Previous studies reported that nephrotic syndrome is associated with ulcerative colitis (UC) patients treated with mesalazine. Dysplasia associated with UC often develops into colorectal carcinoma.CASE PRESENTATION: A 17-year-old man was referred to our hospital, complaining of diarrhea
PMID 27450459

Successful treatment with oral mizoribine in refractory ocular manifestation of mucosal pemphigus vulgaris: A unique response to different immunosuppressive drugs.

Oyama N1,2, Togashi A, Nomura E2, Kaneko F2.
Dermatologic therapy.Dermatol Ther.2016 Jul 15. doi: 10.1111/dth.12386. [Epub ahead of print]
Pemphigus vulgaris (PV) is an acquired autoimmune disease in which the disease characteristic antibodies are directed against the desmosomal transmembrane glycoprotein, desmoglein 3 (Dsg 3), resulting in flaccid blisters and erosions of skin and mucous membrane. Among various affected sites, ocular
PMID 27418118

A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury.

Zhu CZ1, Gopalakrishnan S2, Doyle K2, Nikkel AL2, Olson L2, Abraham VC2, Leys L2, Widomski D2, Salte K2, Putman B2, Pratt S2, Ma J2, Su Z2, Gopalakrishnan M2, Lee CH2, McGaraughty SP2.
European journal of pharmacology.Eur J Pharmacol.2016 Jun 8;788:1-11. doi: 10.1016/j.ejphar.2016.06.012. [Epub ahead of print]
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizing enzyme, ADO kinase (AK). AK inhibitors have dem
PMID 27288879

Japanese Journal

症例報告ミゾリビンパルス療法が有効であった若年女性の全身性エリテマトーデスの1例

野村尚志,江上将平,笠井弘子 [他]
臨床皮膚科 = Japanese journal of clinical dermatology 69(1), 52-56, 2015-01
NAID 40020304039

IgA Nephropathy and Psoriatic Arthritis that Improved with Steroid Pulse Therapy and Mizoribine in Combination with Treatment for Chronic Tonsillitis and Epipharyngitis

, , , , ,
Internal Medicine 54(9), 1085-1090, 2015
… As a renal biopsy showed IgA nephropathy (IgAN), bilateral tonsillectomy was performed, and one course of steroid pulse therapy with an oral steroid and mizoribine were subsequently administered. …
NAID 130005068305

ミゾリビンの関節リウマチにおける市販後調査の集計結果－24週間の使用成績－

岩下輝美,吉田寿雄,岡田研也
臨床リウマチ 27(1), 37-44, 2015
ミゾリビンの関節リウマチ患者に対する使用実態の把握，使用実態下における安全性・有効性に関する情報を収集し，本剤の適正使用に資することを目的として，2008年10月～2010年10月の間に本剤が投与開始された関節リウマチ患者を対象に市販後調査を実施した．安全性解析対象症例3,325例の平均年齢は66.2±12.5歳で，65歳以上が61.1％，75歳以上が28.4％であった．合併症は59.3％に …
NAID 130005067619

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「ミゾリビン」

Mizoribine
Systematic (IUPAC) name
	5-hydroxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	50924-49-7
ATC code	None
PubChem	CID 104762
UNII	4JR41A10VP
KEGG	D01392
Synonyms	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide
Chemical data
Formula	C9H13N3O6
Mol. mass	259.21 g/mol
	SMILES C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N;
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英: mizoribine
商: ブレディニン

[1] Hiroaki Ishikawa (1999). "Mizoribine and Mycophenolate Mofetil". Current Medicinal Chemistry (Bentham Science) 6 (7): 575–597. PMID 10390602.

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mizoribine