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1. ミトコンドリアミオパシー：臨床的特徴および診断 mitochondrial myopathies clinical features and diagnosis
2. ミトコンドリアの構造、機能、および遺伝学 mitochondrial structure function and genetics
3. ミトコンドリアミオパシー：治療 mitochondrial myopathies treatment
4. ミトコンドリア細胞症における腎病変 renal involvement in the mitochondrial cytopathies
5. HIVヌクレオシド系逆転写酵素阻害剤のミトコンドリア毒性 mitochondrial toxicity of hiv nucleoside reverse transcriptase inhibitors

English Journal

Interaction of Poly(ethylenimine)-DNA Polyplexes with Mitochondria; Implications for a Mechanism of Cytotoxicity.

Grandinetti G, Ingle NP, Reineke TM.AbstractPoly(ethylenimine) (PEI) and PEI-based systems have been widely studied for use as nucleic acid delivery vehicles. However, many of these vehicles display high cytotoxicity, rendering them unfit for therapeutic use. By exploring the mechanisms that cause cytotoxicity, and through understanding structure-function relationships between polymers and intracellular interactions, nucleic acid delivery vehicles with precise intracellular properties can be tailored for specific function. Previous research has shown that PEI is able to depolarize mitochondria, but the exact mechanism as to how depolarization is induced remains elusive and therefore is the focus of the current study. Potential mechanisms for mitochondrial depolarization include direct mitochondrial membrane permeabililzation by PEI or PEI polyplexes, activation of the mitochondrial permeability transition pore, and interference with mitochondrial membrane proton pumps, specifically Complex I of the electron transport chain and F0F1-ATPase. Herein, confocal microscopy and live cell imaging showed that PEI polyplexes do colocalize to some degree with mitochondria early in transfection, and the degree of colocalization increases over time. Cyclosporine a was used to prevent activation of the mitochondrial membrane permeability transition pore, and it was found that early in transfection cyclosporine a was unable to prevent the loss of mitochondrial membrane potential. Further studies were done using rotenone and oligomycin to inhibit Complex I of the electron transport chain and F0F1-ATPase, respectively, indicate that both of these mitochondrial proton pumps are functioning during PEI transfection. Overall, we conclude that direct interaction between polyplexes and mitochondria may be the reason why mitochondrial function is impaired during PEI transfection.
Molecular pharmaceutics.Mol Pharm.2011 Jun 23. [Epub ahead of print]
Poly(ethylenimine) (PEI) and PEI-based systems have been widely studied for use as nucleic acid delivery vehicles. However, many of these vehicles display high cytotoxicity, rendering them unfit for therapeutic use. By exploring the mechanisms that cause cytotoxicity, and through understanding struc
PMID 21699201

Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: a key regulator of the metabolic phenotype in cancer.

Willers IM, Cuezva JM.SourceDepartamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), ISCIII, Universidad Autonoma de Madrid, 28049 Madrid, Spain.
Biochimica et biophysica acta.Biochim Biophys Acta.2011 Jun;1807(6):543-51. Epub 2010 Oct 27.
A distinctive metabolic trait of tumors is their enforced aerobic glycolysis. This phenotype was first reported by Otto Warburg, who suggested that the increased glucose consumption of cancer cells under aerobic conditions might result from an impaired bioenergetic activity of their mitochondria. A
PMID 21035425

Japanese Journal

Cruentaren, a New Antifungal Salicylate-Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity : Fermentation and Biological Properties

KUNZE Brigitte,STEINMETZ Heinrich,HOFLE Gerhard,HUSS Markus,WIECZOREK Helmut,REICHENBACH Hans
Journal of antibiotics = An International Journal Devoted to Research on Bioactive Microbial Products 59(10), 664-668, 2006-10-25
NAID 10018348693

生命の誕生とミトコンドリアと肝臓,そして生活習慣病・がん(<特集>九教授定年退職記念講演会)

佐藤信紘
順天堂医学 52(2), 146-151, 2006-06-30
生命は太陽の光エネルギーのもとに,水と空気と地球を形成する種々のミネラルから誕生した.光エネルギーを効率的に捕捉する種々な色素分子の誕生によって,光合成が可能となり,光合成細菌,植物が誕生し,さらに植物の産生する酸素とでんぷんを利用したエネルギーの獲得系,ミトコンドリアを有する真核生物が誕生した.ミトコンドリアを有する生物の進化が人の誕生となった.ミトコンドリアは独自の遺伝子DNAを有し,主に食物 …
NAID 110005858406