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English Journal

Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules.

van der Horst A1, Vromans MJ1, Bouwman K1, van der Waal MS1, Hadders MA1, Lens SM2.
Cell reports.Cell Rep.2015 Jul 21;12(3):380-7. doi: 10.1016/j.celrep.2015.06.038. Epub 2015 Jul 9.
The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metaphase to the spindle midzone in anaphase. In buddi
PMID 26166576

Dimerization mediated by a divergent FHA domain is essential for the DNA damage and spindle functions of fission yeast Mdb1.

Luo S1, Xin X1, Du LL2, Ye K1, Wei Y1.
The Journal of biological chemistry.J Biol Chem.2015 Jul 9. pii: jbc.M115.642538. [Epub ahead of print]
MDC1 is a key factor of DNA damage response in mammalian cells. It possesses two phospho-binding domains. In its C-terminus, a tandem BRCA1 C-terminal (tBRCT) domain binds phosphorylated histone H2AX, and in its N-terminus, a forkhead-associated (FHA) domain mediates a phosphorylation-enhanced homod
PMID 26160178

The Arabidopsis mitogen-activated protein kinase 6 is associated with γ-tubulin on microtubules, phosphorylates EB1c and maintains spindle orientation under nitrosative stress.

Kohoutová L1, Kourová H1, Nagy SK2, Volc J1, Halada P1, Mészáros T2,3, Meskiene I4,5, Bögre L6, Binarová P1.
The New phytologist.New Phytol.2015 Jun 9. doi: 10.1111/nph.13501. [Epub ahead of print]
Stress-activated plant mitogen-activated protein (MAP) kinase pathways play roles in growth adaptation to the environment by modulating cell division through cytoskeletal regulation, but the mechanisms are poorly understood. We performed protein interaction and phosphorylation experiments with cytos
PMID 26061286