WordNet
- a microscopically small tubule
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.
- Zghaib Z1, Guichou JF2, Vappiani J3, Bec N4, Hadj-Kaddour K3, Vincent LA3, Paniagua-Gayraud S3, Larroque C4, Moarbess G5, Cuq P3, Kassab I5, Deleuze-Masquéfa C6, Diab-Assaf M5, Bonnet PA3.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2433-40. doi: 10.1016/j.bmc.2016.04.004. Epub 2016 Apr 1.
- Microtubules are considered as important targets of anticancer therapy. EAPB0503 and its structural imidazo[1,2-a]quinoxaline derivatives are major microtubule-interfering agents with potent anticancer activity. In this study, the synthesis of several new derivatives of EAPB0503 is described, and th
- PMID 27094151
- Molecular insight into the regulation and function of MCAK.
- Ritter A1, Kreis NN1, Louwen F1, Wordeman L2, Yuan J1.
- Critical reviews in biochemistry and molecular biology.Crit Rev Biochem Mol Biol.2016 May 5:1-18. [Epub ahead of print]
- Chromosome stability is ensured by precisely fine-tuned dynamics of mitotic spindles, which are controlled by a network of various microtubule-associated and interacting proteins including the kinesin-13 family. The best characterized member of this family is the mitotic centromere-associated kinesi
- PMID 27146484
- Indole based tubulin polymerization inhibitors: An update on recent developments.
- Sunil D1, Kamath PR.
- Mini reviews in medicinal chemistry.Mini Rev Med Chem.2016 May 5. [Epub ahead of print]
- The exploration of cancer microenvironment and its physiology have exposed a number of potential molecular targets for selective therapeutic intervention by anti-cancer agents. Microtubules are basic cell components formed by polymerization of αβ heterodimers which play a pivotal role in cellular
- PMID 27145853
Japanese Journal
- New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis
- Sato Hiromi,Yamada Ryota,Yanagihara Midori [他],OKUZAWA Hiroko,IWATA Hiroki,KUROSAWA Ayako,ICHINOMIYA Saki,SUZUKI Rina,OKABE Hiroyuki,YANO Tomohiro,KUMAMOTO Takuya,SUZUKI Noriyuki,ISHIKAWA Tsutomu,UENO Koichi
- Journal of pharmacological sciences 118(4), 467-478, 2012-04-20
- … Moreover, it could cause microtubule depolymerization both in vitro and in vivo. … In conclusion, QO-1 has promising antitumor effects via microtubule depolymerization. …
- NAID 10030572009
- Relationship between the Structures of Taxane Derivatives and Their Microtubule Polymerization Activity
- HIDAKA Masafumi,KOGA Tomoe,KIYOTA Hiromasa [他],HORIGUCHI Tohru,SHI Qing-Wen,HIROSE Keiko,UCHIDA Takafumi
- Bioscience, biotechnology, and biochemistry 76(2), 349-352, 2012-02-23
- … Paclitaxel (Taxol), one of the most potent anticancer drugs, is a microtubule-stabilizing compound that inhibits microtubule depolymerization within the cell. …
- NAID 10030400057
- Cytoskeletal and Ultrastructural Studies on Regenerating Cells from the Protoplasts of Valonia (Siphonocladales, Chlorophyceae)
- Elvira Paul Rommel,Okuda Kazuo
- 黒潮圏科学 5(1), 39-49, 2011-03-00
- … A new cell wall was produced within 24 hours simultaneous with CMT andAF depolymerization. …
- NAID 40019151989
Related Links
- Introduction Kinesin superfamily proteins (KIFs) are microtubule-based molecular motors that hydrolyze ATP to provide energy to support various cellular functions, such as intracellular transport and the regulation of ...
- Electron microscopy of microtubules decorated with motor protein heads indicate a "3 start helix" in which each turn of the helix spans 3 tubulin monomers (e.g., a, b, a). This results in the microtubule wall having a "seam ...
★リンクテーブル★
[★]
- 英
- microtubule depolymerization
[★]
- 関
- degradation、depolymerize