メチクラン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/25 09:48:40」(JST)
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Meticrane
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral |
ATC code |
|
Legal status |
Legal status |
- In general: ℞ (Prescription only)
|
Identifiers |
IUPAC name
- 6-methylthiochromane-7-sulfonamide 1,1-dioxide
|
PubChem CID |
|
ChemSpider |
|
UNII |
|
ECHA InfoCard |
100.012.830 |
Chemical and physical data |
Formula |
C10H13NO4S2 |
Molar mass |
275.34 g/mol |
3D model (JSmol) |
|
SMILES
-
CC1=C(C=C2C(=C1)CCCS2(=O)=O)S(=O)(=O)N
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InChI
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InChI=1S/C10H13NO4S2/c1-7-5-8-3-2-4-16(12,13)10(8)6-9(7)17(11,14)15/h5-6H,2-4H2,1H3,(H2,11,14,15)
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Key:FNQQBFNIYODEMB-UHFFFAOYSA-N
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(verify) |
Meticrane (INN) is a diuretic.
Antihypertensives: diuretics (C03)
|
Sulfonamides
(and etacrynic acid) |
CA inhibitors (at PT) |
|
Loop (Na-K-Cl at AL) |
- Furosemide#
- Bumetanide
- Etacrynic acid
- Etozolin
- Muzolimine
- Ozolinone
- Piretanide
- Tienilic acid
- Torasemide
|
Thiazides (Na-Cl at DCT,
Calcium-sparing) |
- Altizide
- Bendroflumethiazide
- Chlorothiazide
- Cyclopenthiazide
- Cyclothiazide
- Epitizide
- Hydrochlorothiazide#
- Hydroflumethiazide
- Mebutizide
- Methyclothiazide
- Polythiazide
- Trichlormethiazide
|
Thiazide-likes (primarily DCT) |
- Quinethazone
- Clopamide
- Chlortalidone
- Mefruside
- Clofenamide
- Metolazone
- Meticrane
- Xipamide
- Indapamide
- Clorexolone
- Fenquizone
|
|
Potassium-sparing (at CD) |
ESC blockers |
- Amiloride#
- Triamterene
- Benzamil
|
Aldosterone antagonists |
- Spirolactones: Spironolactone#
- Eplerenone
- Potassium canrenoate
- Canrenone
|
|
Osmotic diuretics (PT, DL) |
|
Vasopressin receptor inhibitors
(DCT and CD) |
- Vaptans: Conivaptan
- Mozavaptan
- Satavaptan
- Tolvaptan
- Others: Demeclocycline
- Lithium carbonate
|
Other |
- Ethanol, Isopropanol, 2M2B
- mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
- Theobromine
- Cicletanine
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
English Journal
- [Resorption, distribution, excretion and metabolism in rat of a new diuretic: meticrane].
- Boissier JR, Hirtz J, Dumont C, Gérardin A.
- Annales pharmaceutiques francaises.Ann Pharm Fr.1970 Jul-Aug;28(7):497-509.
- PMID 5485056
- [Clinical trial of a new diuretic: meticrane].
- Linquette M, Decoulx M.
- Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille.Lille Med.1968 Jan;13(1):Suppl:13-6.
- PMID 5745602
Japanese Journal
- Crystal Structure of Meticrane
- TANAKA Rumiko,HIRAYAMA Noriaki
- Analytical Sciences: X-ray Structure Analysis Online 23, X119-X120, 2007
- The crystal of the title compound, C10H13NO4S2, belongs to space group Pbca with cell dimensions a = 10.070(2), b = 14.362(3), and c =16.237(3)Å. The final R value is 0.057. The 3,4-dihydro-2H-thiop …
- NAID 130004442777
- 内服試験陽性であったメチクランによる白斑黒皮症の1例
- 井上 佳代,濱本 嘉昭,倉田 佳子,中村 知恵,武藤 正彦
- 西日本皮膚科 = The Nishinihon journal of dermatology 61(3), 346-349, 1999-06-01
- NAID 10019139770
- 内服試験陽性であったメチクランによる白斑黒皮症の1例
- 井上 佳代,濱本 嘉昭,倉田 佳子,中村 知恵,武藤 正彦
- 西日本皮膚科 61(3), 346-349, 1999
- 非サイアザイド系の降圧剤, メチクランによる薬疹の1例を報告した。症例は65歳の女性。同薬の内服開始約2年半後に顔面, 頚部および上肢にそう痒性の浮腫性紅斑が生じた。その3ヵ月後, 皮疹は白斑黒皮症様となった。メチクラン内服, 内服照射試験ともに陽性。メチクランによる薬疹と診断。初期では光化学反応を介さない機序が関与していることが考えられた。
- NAID 130004474545
★リンクテーブル★
[★]
- 英
- meticrane
- 商
- アレステン