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The metaphysis (/mətˈæfᵻsᵻs/) is the wide portion of a long bone between the epiphysis and the narrow diaphysis.^[1] It contains the growth plate, the part of the bone that grows during childhood and as it grows, it ossifies near the diaphysis and the epiphyses.

The growth plate may be divided anatomically into three components based on tissue content: a cartilaginous component (epiphyseal plate), a bony component (metaphysis) and a fibrous component surrounding the periphery of the plate. The growth plate synchronizes chondrogenesis with osteogenesis or interstitial cartilage growth with appositional bone growth at the same that it is growing in width, bearing load, and responding to local and systemic forces and factors.

During childhood, the growth plate contains the connecting cartilage enabling the bone to grow; at adulthood (between the ages of 18 to 25 years), the components of the growth plate stop growing altogether and completely ossify into solid bone.^[2] In an adult, the metaphysis functions to transfer loads from weight-bearing joint surfaces to the diaphysis.^[3]

Clinical significance

Because of their rich blood supply and vascular stasis, metaphyses of long bones are prone to hematogenous spread of osteomyelitis in children.^[4]

Metaphyseal tumors or lesions include osteosarcoma, chondrosarcoma, fibrosarcoma, osteoblastoma, enchondroma, fibrous dysplasia, simple bone cyst, aneurysmal bone cyst, non-ossifying fibroma, and osteoid osteoma.^[5]

One of the clinical signs of rickets that doctors look for is cupping and fraying at the metaphyses when seen on X-ray.

References

^ Dorland's Pocket Medical Dictionary, 27th edition
^ Visual dictionary of Merriam-Webster http://visual.merriam-webster.com/human-being/anatomy/skeleton/parts-long-bone.php
^ Encyclopedia Britanica, http://www.britannica.com/EBchecked/topic/377978/metaphysis
^ Luqmani, Raashid; Robb, James; Daniel, Porter; Benjamin, Joseph (2013). Orthopaedics, Trauma and Rheumatology (second ed.). Mosby. p. 96. ISBN 9780723436805.
^ "New Jersey Medical School, Pathology Department Introductory Course on Bone Tumours". Retrieved 2009-03-12.

External links

Anatomy photo: Musculoskeletal/bone/structure0/structure2^{[dead link]} - Comparative Organology at University of California, Davis - "Bone, structure (Gross, Low)"

UpToDate Contents

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2. 小児におけるくる病の概要 overview of rickets in children
3. 小児における血行性骨髄炎：疫学、病因、および微生物学 hematogenous osteomyelitis in children epidemiology pathogenesis and microbiology
4. 小児の栄養障害と関連した微量栄養素欠乏 micronutrient deficiencies associated with malnutrition in children
5. 致死的骨格形成異常の出生前診断 prenatal diagnosis of the lethal skeletal dysplasias

English Journal

Metaphyseal chondromatosis combined with D-2-hydroxyglutaric aciduria in four patients.

Choo HJ, Cho TJ, Song J, Tiller GE, Lee SH, Park G, Lee IS, Lachman R, Superti-Furga A, Kim OH.SourceDepartment of Radiology, Inje University Pusan Paik Hospital, Pusan, Korea.
Skeletal radiology.Skeletal Radiol.2012 Nov;41(11):1479-87. Epub 2012 May 26.
We report four patients who presented with a severe form of metaphyseal chondromatosis in association with D-2-hydroxyglutaric aciduria (D-2-HGA). All patients showed splaying columns of irregular ossification defects with bulbous metaphyses of the long tubular bones, as well as remarkable involveme
PMID 22639207

A paradigm for the development and evaluation of novel implant topologies for bone fixation: In vivo evaluation.

Long JP, Hollister SJ, Goldstein SA.SourceDepartment of Orthopaedic Surgery, the University of Michigan, United States. Electronic address: longjp@umich.edu.
Journal of biomechanics.J Biomech.2012 Oct 11;45(15):2651-7. doi: 10.1016/j.jbiomech.2012.08.011. Epub 2012 Sep 2.
While contemporary prosthetic devices restore some function to individuals who have lost a limb, there are efforts to develop bio-integrated prostheses to improve functionality. A critical step in advancing this technology will be to securely attach the device to remnant bone. To investigate mechani
PMID 22951278

Japanese Journal

Sclerostin is differently immunolocalized in metaphyseal trabecules and cortical bones of mouse tibiae

Biomedical Research 34(3), 153-159, 2013
NAID 130004470846

Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats

Biomedical Research 32(4), 259-269, 2011
NAID 130004903823

Aneurysmal Bone Cyst of the Patella

Journal of Hard Tissue Biology 20(2), 161-164, 2011
NAID 130004480523

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★リンクテーブル★

リンク元

「骨幹端」

Metaphysis
	Structure of a long bone showing the metaphysis.
Details
Identifiers
Latin	metaphysis
TA	A02.0.00.022
FMA	24014
	Anatomical terminology [edit on Wikidata]

　　[★]

英: metaphysis, (pl.)metaphyses

[1] Dorland's Pocket Medical Dictionary, 27th edition

[2] Visual dictionary of Merriam-Webster http://visual.merriam-webster.com/human-being/anatomy/skeleton/parts-long-bone.php

[3] Encyclopedia Britanica, http://www.britannica.com/EBchecked/topic/377978/metaphysis

[Luqmani-4] Luqmani, Raashid; Robb, James; Daniel, Porter; Benjamin, Joseph (2013). Orthopaedics, Trauma and Rheumatology (second ed.). Mosby. p. 96. ISBN 9780723436805.

[urlInroductory_Course-5] "New Jersey Medical School, Pathology Department Introductory Course on Bone Tumours". Retrieved 2009-03-12.

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metaphyses