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Hepatic biotransformation of alkylresorcinols is mediated via cytochrome P450 and β-oxidation: A proof of concept study.

Marklund M, McKeown NM, Blumberg JB, Chen CY.SourceJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Food chemistry.Food Chem.2013 Aug 15;139(1-4):925-30. doi: 10.1016/j.foodchem.2013.01.122. Epub 2013 Feb 13.
Alkylresorcinols (AR) are phenolic lipids present in the bran of some cereals. AR may serve as a biomarker for whole grain wheat and rye intake. While AR pharmacokinetics and two major metabolites have been reported, the metabolic pathways contributing to their relatively rapid elimination from the
PMID 23561191

Croton lechleri Müll. Arg. (Euphorbiaceae) stem bark essential oil as possible mutagen-protective food ingredient against heterocyclic amines from cooked food.

Rossi D, Guerrini A, Paganetto G, Bernacchia G, Conforti F, Statti G, Maietti S, Poppi I, Tacchini M, Sacchetti G.SourceDipartimento di Scienze della Vita e Biotecnologie (SVeB) - LT Terra&Acqua Tech UR7, Università degli Studi di Ferrara, C.so Ercole I d'Este 32, I-44121 Ferrara, Italy.
Food chemistry.Food Chem.2013 Aug 15;139(1-4):439-47. doi: 10.1016/j.foodchem.2013.01.076. Epub 2013 Feb 7.
The Amazonian Croton lechleri stem bark essential oil was tested for its anti-mutagenic potential by performing the Ames test against heterocyclic amines (HCAs), in continuing research on applicative functional profile of this phytocomplex as food ingredient (Rossi et al., 2011). Salmonella typhimur
PMID 23561129

A new process for obtaining hydroxytyrosol using transformed Escherichia coli whole cells with phenol hydroxylase gene from Geobacillus thermoglucosidasius.

Orenes-Piñero E, García-Carmona F, Sánchez-Ferrer A.SourceDepartment of Biochemistry and Molecular Biology-A, Faculty of Biology, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Campus Espinardo, E-30100 Murcia, Spain.
Food chemistry.Food Chem.2013 Aug 15;139(1-4):377-83. doi: 10.1016/j.foodchem.2012.12.063. Epub 2013 Feb 1.
Phenol hydroxylase gene cloning from the thermophilic bacteria Geobacillus thermoglucosidasius was used to develop an effective method to convert tyrosol into the high-added-value compound hydroxytyrosol by hydroxylation. Phenol hydroxylase is a two-component enzyme encoded by pheA1 and pheA2 genes
PMID 23561120

Oxidation of N-Alkyl-N-(3-carboxypropyl)nitrosamines by Iron Porphyrin and Oxidant Forms Alkylating Mutagens

Inami Keiko,Yasui Hiroki,Tsugumi Hirotaka [他]
Genes and environment : the official journal of the Japanese Environmental Mutagen Society 35(4), 99-104, 2013-11
NAID 40019868021

α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells

Michikoshi Hiromitsu,Nakamura Takahiro,Sakai Katsuya,Suzuki Yoshinori,Adachi Eri,Matsugo Seiichi,Matsumoto Kunio
Cancer Letters 335(2), 472-478, 2013-07-28
… α-Lipoic acid (α-LA), a naturally occurring anti-oxidant and co-factor for metabolic enzymes, suppresses the growth of different types of tumor cells. … In the present study, we investigated the effects of α-LA on the proliferation and activation status of definitive receptor tyrosine kinases, epidermal growth factor receptor (EGFR) and Met/hepatocyte growth factor (HGF) receptor, in gefitinib-sensitive human non-small cell lung cancer cells harboring EGFRs with an activating mutation. …
NAID 120005254051

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

Kimura Ikuo,Ozawa Kentaro,Inoue Daisuke,Imamura Takeshi,Kimura Kumi,Maeda Takeshi,Terasawa Kazuya,Kashihara Daiji,Hirano Kanako,Tani Taeko,Takahashi Tomoyuki,Miyauchi Satoshi,Shioi Go,Inoue Hiroshi,Tsujimoto Gozoh
Nature communications 4, 2013-05-07
… Here we show that the short-chain fatty acid receptor GPR43 links the metabolic activity of the gut microbiota with host body energy homoeostasis. … We further show that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. …
NAID 120005244704