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a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/12 13:17:23」(JST)

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Mepivacaine /mɛˈpɪvəkeɪn/ is a local anesthetic^[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.

Mepivacaine became available in the United States in the 1960s.

Mepivacaine is used in any infiltration and regional anesthesia.

It is supplied as the hydrochloride salt of the racemate.^[2]

References

^ Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal. 12 (1): E60–4. PMID 17195831.
^ Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005.

External links

Mepivacaine at RxList

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1. 局所麻酔剤の浸潤 infiltration of local anesthetics
2. 局所麻酔剤に対するアレルギー反応 allergic reactions to local anesthetics
3. 陰部神経ブロックおよび傍子宮頸管ブロック pudendal and paracervical block
4. Spinal anesthesia: Technique
5. 末梢神経ブロックの概要 overview of peripheral nerve blocks

English Journal

The effects of perineural and intrasynovial anaesthesia of the equine foot on subsequent magnetic resonance images.

Black B, Cribb NC, Nykamp SG, Thomason JJ, Trout DR.SourceDepartments of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Equine veterinary journal.Equine Vet J.2013 May;45(3):320-5. doi: 10.1111/j.2042-3306.2012.00649.x. Epub 2012 Sep 26.
REASONS FOR PERFORMING STUDY: Artefacts caused by regional anaesthesia can influence image interpretation of ultrasonography and nuclear scintigraphy. Perineural and intrasynovial anaesthesia are commonly performed prior to magnetic resonance imaging (MRI); and the effects on MR images, if any, are
PMID 23009340

Intraarticular Local Anesthesia: Can It Reduce Pain Related to MR or CT Arthrography of the Shoulder?

Choo HJ, Lee SJ, Kim DW, Choi SJ, Lee IS.Source1 Department of Radiology, College of Medicine, Inje University Busan Paik Hospital, Gaegeum-dong Jin-gu, Busan, Republic of Korea, 614-735.
AJR. American journal of roentgenology.AJR Am J Roentgenol.2013 Apr;200(4):860-7. doi: 10.2214/AJR.12.9349.
OBJECTIVE. The objective of this study was to prospectively evaluate whether intraarticular anesthesia can reduce pain after MR or CT arthrography of the shoulder. SUBJECTS AND METHODS. This study included 120 patients who underwent CT or MR arthrography of the shoulder. The patients were randomized
PMID 23521461

Ultrasound-Guided Root/Trunk (Interscalene) Block for Hand and Forearm Anesthesia.

Madison SJ, Humsi J, Loland VJ, Suresh PJ, Sandhu NS, Bishop MJ, Donohue MC, Nie D, Ferguson EJ, Morgan AC, Ilfeld BM.SourceFrom the *University California, San Diego, San Diego, CA; and †Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA.
Regional anesthesia and pain medicine.Reg Anesth Pain Med.2013 Mar 22. [Epub ahead of print]
BACKGROUND: Historically, the anterolateral interscalene block-deposition of local anesthetic adjacent to the brachial plexus roots/trunks-has been used for surgical procedures involving the shoulder. The resulting block frequently failed to provide surgical anesthesia of the hand and forearm, even
PMID 23528646

Japanese Journal

斜角筋間腕神経叢ブロックによる肩関節鏡手術

杉原隆之
肩関節 35(2), 633-635, 2011
… Mepivacaine hydrochloride (1.5%) was used with an average of 23.6ml and ropivacaine hydrochloride hydrate (0.75%) was used with an average of 20.0ml. …
NAID 130001413768

肩手術に対する斜角筋間腕神経叢ブロックの使用経験

杉原隆之,中川照彦,宗田大,四宮謙一
肩関節 = Shoulder joint 33(2), 563-565, 2009-07-27
… Skin puncture was performed at about 3cm upper part of the middle of the clavicle, and Mepivacaine hydrochloride (1.5%) was injected. … Mepivacaine hydrochloride (1.5%) was used with 20-30ml (average 26.3ml). … Small volumes of local anesthesia (lidocaine hydrochloride) were used in 3 cases additionally at the skin incision. …
NAID 10025335859

「hydrochloride」

Mepivacaine
Systematic (IUPAC) name
	(RS)-N-(2,6-dimethylphenyl)- 1-methyl-piperidine-2-carboxamide
Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a603026
Pregnancy; category	C, use w/ caution, may cause fetal bradycardia;
Identifiers
CAS Number	96-88-8
ATC code	N01BB03 (WHO)
PubChem	CID 4062
IUPHAR/BPS	7224
DrugBank	DB00961
ChemSpider	3922
UNII	B6E06QE59J
KEGG	D08181
ChEBI	CHEBI:6759
ChEMBL	CHEMBL1087
Chemical data
Formula	C15H22N2O
Molar mass	246.348 g/mol
	SMILES O=C(Nc1c(cccc1C)C)C2N(C)CCCC2 ;
	InChI InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18) ; Key:INWLQCZOYSRPNW-UHFFFAOYSA-N ;
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　　[★] 塩酸塩、ハイドロクロライド　

[pmid17195831-1] Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal. 12 (1): E60–4. PMID 17195831.

[pmid8989005-2] Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005.

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案内

mepivacaine hydrochloride