エピリゾール、メピリゾール
English Journal
- STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.
- Khomenko T1, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S.
- Digestive diseases and sciences.Dig Dis Sci.2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
- OBJECTIVES: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that directly upregulates VEGF, Ref-1, p21, and anti-apoptotic genes such as Bcl-xL. In this study, we hypothesized that STAT3 signaling is activated and provides a critical protective role that is requi
- PMID 24385009
- Discovery of lansoprazole and its unique pharmacological properties independent from anti-secretory activity.
- Satoh H.
- Current pharmaceutical design.Curr Pharm Des.2013;19(1):67-75.
- The proton pump inhibitors (PPIs) lansoprazole (LPZ) and omeprazole (OPZ) have been widely used for more than 20 years in the treatment of acid-related diseases such as gastro-duodenal ulcers and reflux esophagitis. Both LPZ and OPZ are derivatives of 2-[(2- pyridylmethyl)sulfinyl]-1H-benzimidazole,
- PMID 22950496
- Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.
- Rovira M1, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2011 Nov 29;108(48):19264-9. doi: 10.1073/pnas.1113081108. Epub 2011 Nov 14.
- Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to identify compounds that would induce the differentiation of insulin-producing β-cells in vivo. To do this screen, we brought together the us
- PMID 22084084
Japanese Journal
- A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats
- Journal of pharmacological sciences 106(2), 249-256, 2008-02-20
- NAID 10024318339
- Cytoprotective Effects of 4,6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl・Ethanol-Induced Gastric Lesions in Rats
- Cytoprotective Effects of 4,6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HClEthanol-Induced Gastric Lesions in Rats.
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