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A megakaryoblast is a precursor cell to a promegakaryocyte, which in turn becomes a megakaryocyte during haematopoiesis. It is the beginning of the thrombocytic series.

Origin

The megakaryoblast derives from a CFU-Me colony unit of pluripotential hemopoietic stem cells. (Some sources use the term "CFU-Meg" to identify the CFU.^[1]) The CFU-Meg derives from the CFU-GEMM (common myeloid progenitor).

Structure

These cells tend to range from 8μm to 30μm, owing to the variation in size between different megakaryoblasts.^[2] The nucleus is three to five times the size of the cytoplasm, and is generally round or oval in shape. Several nucleoli are visible, while the chromatin varies from cell to cell, ranging from fine to heavy and dense. The cytoplasm is generally basophilic and stains blue. In smaller cells, it contains no granules, but larger megakaryoblasts may contain fine granules.^[3]

References

^ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
^ McClatchey, Kenneth, ed. (2002). Clinical Laboratory Medicine. Lippincott Williams & Wilkins. p. 802. ISBN 0683307517.
^ Anderson, Shauna (2013). Anderson's Atlas of Hematology. Lippincott Williams & Wilkins. p. 129. ISBN 1469826364.

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English Journal

Megakaryocyte Polyploidization and Proplatelet Formation in Low-Attachment Conditions.

Schlinker AC1, Duncan MT1, DeLuca TA1, Whitehead DC1, Miller WM1.
Biochemical engineering journal.Biochem Eng J.2016 Jul 15;111:24-33.
In vitro-derived platelets (PLTs), which could provide an alternative source of PLTs for patient transfusions, are formed from polyploid megakaryocytes (MKs) that extend long cytoplasmic projections, termed proplatelets (proPLTs). In this study, we compared polyploidization and proPLT formation (PPF
PMID 27087780

The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line.

Wang HT1,2,3, Yang B1, Hu B2,4, Chi XH5, Luo LL2, Yang HQ1, Lang XL2, Geng J2, Qiao CX2, Li Y2, Wu XX3, Zhu HL1, Lv M2, Lu XC1.
Cancer medicine.Cancer Med.2016 May 26. doi: 10.1002/cam4.759. [Epub ahead of print]
Amifostine is a cytoprotective drug that was initially used to control and treat nuclear radiation injury and is currently used to provide organ protection in cancer patients receiving chemotherapy. Clinical studies have also found that amifostine has some efficacy in the treatment of cytopenia caus
PMID 27228575

Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.

Ishiyama K1, Yamaguchi T2, Eto T3, Ohashi K4, Uchida N5, Kanamori H6, Fukuda T7, Miyamura K8, Inoue Y9, Taguchi J10, Mori T11, Iwato K12, Morishima Y13, Nagamura-Inoue T14, Atsuta Y15, Sakamaki H4, Takami A16.
Leukemia research.Leuk Res.2016 May 12;47:47-53. doi: 10.1016/j.leukres.2016.04.017. [Epub ahead of print]
Acute erythroid leukemia (FAB-M6) and acute megakaryoblastic leukemia (FAB-M7) exhibit closely related properties in cells regarding morphology and the gene expression profile. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the mainstay of the treatment for bot
PMID 27244257

Japanese Journal

急性巨核芽球性白血病の犬の1例

舛方祐子,林聡恵,秋吉秀保 [他],大橋文人,玉本智枝,望月浩之,辻本元,安田和雄
日本獣医師会雑誌 68(3), 182-187, 2015
12歳，去勢雄の雑種犬が跛行と元気消失を主訴に来院した．血液塗抹では芽球様細胞が観察され，針生検にて骨髄及び脾臓に巨核球様芽球細胞の著しい増殖が認められた．同細胞はフローサイトメトリー（FCM）にて，血小板及び巨核球に発現するCD41/CD61抗原に陽性を示すことから，巨核球系細胞に由来することが示され，本症例は急性巨核芽球性白血病（AML-M7）と診断された．プレドニゾロン投与により一般状態は改 …
NAID 130005065123

非ダウン症小児急性巨核芽球性白血病にみとめられた新規GATA1インフレーム変異

王汝南,金崎里香,土岐力 [他],照井君典,佐々木伸也,工藤耕,神尾卓哉,佐藤知彦,池田史圭,荒木亮,落合英俊,伊藤悦朗
弘前醫學 65(2/3/4), 227-237, 2014-09-30
ダウン症児は巨核芽球性白血病（DS－AMKL）のリスクが高い．DS－AMKL ではほぼ全例でGATA1 遺伝子変異があり，N末端領域を欠くGATA1s だけが発現する．非ダウン症例（non－DS－AMKL）にはこの変異は稀である．最近我々は，19例中1例のnon－DS－AMKL にインフレーム欠失を見出した．患児は出生時より白血球増多を認め，生後1 ヶ月時にAMKL と診断された．芽球の核型は4 …
NAID 110009838312

Detection of RBM15-MKL1 Fusion Was Useful for Diagnosis and Monitoring of Minimal Residual Disease in Infant Acute Megakaryoblastic Leukemia

Takeda Akiko,Shimada Akira,Hamamoto Kazuko,Yoshino Syuuji,Nagai Tomoko,Fujii Yousuke,Yamada Mutsuko,Nakamura Yoshimi,Watanabe Toshiyuki,Watanabe Yuki,Yamamoto Yuko,Sakakibara Kanae,Oda Megumi,Morishima Tsuneo
Acta Medica Okayama 68(2), 119-123, 2014-04
Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of thi …
NAID 120005425628