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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/20 16:47:34」(JST)

Mefruside (INN) is a diuretic indicated for the treatment of edema and hypertension.^[1]

It was developed by Bayer A.G. and is sold under the tradename Baycaron.

References

^ Allen HB, Lee DA (1973). "A general practice assessment of mefruside ('Baycaron') in the treatment of oedema and hypertension". Curr Med Res Opin 1 (9): 547–53. doi:10.1185/03007997309111720. PMID 4779251.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

Salcius M1, Bauer AJ1, Hao Q2, Li S2, Tutter A1, Raphael J1, Jahnke W3, Rondeau JM3, Bourgier E3, Tallarico J1, Michaud GA4.
Journal of biomolecular screening.J Biomol Screen.2014 Feb 19;19(6):917-927. [Epub ahead of print]
Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehensive view of the target(s) for both early tool molecules and even late-stage drugs. To address this
PMID 24554445

On the inter-instrument and the inter-laboratory transferability of a tandem mass spectral reference library. 3. Focus on ion trap and upfront CID.

Oberacher H1, Pitterl F, Siapi E, Steele BR, Letzel T, Grosse S, Poschner B, Tagliaro F, Gottardo R, Chacko SA, Josephs JL.
Journal of mass spectrometry : JMS.J Mass Spectrom.2012 Feb;47(2):263-70. doi: 10.1002/jms.2961.
Mass spectral libraries represent versatile tools for the identification of small bioorganic molecules. Libraries based on electron impact spectra are rated robust and transferable. Tandem mass spectral libraries are often considered to work properly only on the instrument that has been used to buil
PMID 22359338

Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.

Beyer J1, Bierl A, Peters FT, Maurer HH.
Therapeutic drug monitoring.Ther Drug Monit.2005 Aug;27(4):509-20.
A gas chromatography-mass spectrometry (GC-MS)-based screening procedure was developed for the detection of diuretics, uricosurics, and/or their metabolites in human urine after extractive methylation. Phase-transfer catalyst remaining in the organic phase was removed by solid-phase extraction on a
PMID 16044110

Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship.

斎藤文雄,木村玄次郎,下崎芳里,藤井隆,石井達男,吉田馨,阿部仁,川村実,出口不二夫,河野雄平,小嶋俊一,横内正利,吉見宏樹,倉持衛夫,佐谷誠,伊藤敬一,尾前照雄
日本腎臓学会誌 29(4), 461-467, 1987
… The mechanisms of the hypotensive action of a sulfonamide diuretic, mefruside (M), were analyzed based on the pressure-natriuresis relationship. … These results suggest that extreme restriction of the dietary sodium intake is not necessary under the treatment of an antihynertensive diuretic, mefruside. …
NAID 130004169345

Blood Pressure and Sympathetic Nervous Function in Spontaneously Hypertensive Rats Derived from Breeders on Low Sodium Diet : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

FUKIYAMA Koshiro,TAKISHITA Shuichi,ETO Tanenao,KIMURA Yorio,TOMITA Yuji,KAWAZOE Nobuyuki,OMAE Teruo,TSUMAGARI Tatsumi,OHNISHI Kenichi
Japanese circulation journal 50(11), 1170-1173, 1986-11-20
… Weaning SHRs (F-0) were divided into 3 groups and were given a diets containing sodium of 0.4% (G1), 0.05% (G2), or 0.4% plus mefruside 0.001% (G3) with distilled water. …
NAID 110002585244

Blood pressure and sympathetic nervous function in spontaneously hypertensive rats derived from breeders on low sodium diet.

FUKIYAMA Koshiro,TAKISHITA Shuichi,ETO Tanenao,KIMURA Yorio,TOMITA Yuji,KAWAZOE Nobuyuki,OMAE Teruo,TSUMAGARI Tatsumi,OHNISHI Kenichi
Japanese Circulation Journal 50(11), 1170-1173, 1986
… Weaning SHRs (F-0) were divided into 3 groups and were given a diets containing sodium of 0.4% (G1), 0.05% (G2), or 0.4% plus mefruside 0.001% (G3) with distilled water. …
NAID 130003547470

リンク元

Mefruside
Systematic (IUPAC) name
	4-chloro-N1-methyl-N1-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	Oral
Identifiers
CAS number	7195-27-9
ATC code	C03BA05
PubChem	CID 4047
ChemSpider	3907
UNII	X1NS9SNS92
KEGG	D01877
Chemical data
Formula	C13H19ClN2O5S2
Molecular mass	382.88 g/mol
	SMILES CC1(CCCO1)CN(C)S(=O)(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N;
	InChI InChI=1S/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18) ; Key:SMNOERSLNYGGOU-UHFFFAOYSA-N ;
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Systematic (IUPAC) name

4-chloro-N¹-methyl-N¹-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	7195-27-9^Y
ATC code	C03BA05
PubChem	CID 4047
ChemSpider	3907^N
UNII	X1NS9SNS92^Y
KEGG	D01877^Y
Chemical data
Formula	C₁₃H₁₉ClN₂O₅S₂
Molecular mass	382.88 g/mol
SMILES CC1(CCCO1)CN(C)S(=O)(=O)C2=CC(=C(C=C2)Cl)S(=O)(=O)N
InChI InChI=1S/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18)^N Key:SMNOERSLNYGGOU-UHFFFAOYSA-N^N
N (what is this?) (verify)