マンニトール脱水素酵素、マンニトールデヒドロゲナーゼ
WordNet
- a diuretic (trade name Osmitrol) used to promote the excretion of urine (同)Osmitrol
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/30 03:50:31」(JST)
[Wiki en表示]
| mannitol dehydrogenase |
| Identifiers |
| EC number |
1.1.1.255 |
| CAS number |
144941-29-7 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a mannitol dehydrogenase (EC 1.1.1.255) is an enzyme that catalyzes the chemical reaction
- D-mannitol + NAD+ D-mannose + NADH + H+
Thus, the two substrates of this enzyme are D-mannitol and NAD+, whereas its 3 products are D-mannose, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mannitol:NAD+ 1-oxidoreductase. Other names in common use include MTD, and NAD+-dependent mannitol dehydrogenase.
References
- Stoop JM, Pharr DM (1992). "Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots". Arch. Biochem. Biophys. 298 (2): 612–9. PMID 1416989. doi:10.1016/0003-9861(92)90456-7.
- Stoop JM, Williamson JD, Conkling MA, Pharr DM (1995). "Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures". Plant. Physiol. 108 (3): 1219–25. PMC 157476 . PMID 7630943. doi:10.1104/pp.108.3.1219.
- Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM (1995). "Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7148–52. PMC 41296 . PMID 7638158. doi:10.1073/pnas.92.16.7148.
- Stoop, JMH, Chilton WS, Pharr DM (1996). "Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery". Phytochemistry. 43 (6): 1145–1150. doi:10.1016/S0031-9422(96)00423-2.
See also
|
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
|
| 1.1.1: NAD/NADP acceptor |
- 3-hydroxyacyl-CoA dehydrogenase
- 3-hydroxybutyryl-CoA dehydrogenase
- Alcohol dehydrogenase
- Aldo-keto reductase
- 1A1
- 1B1
- 1B10
- 1C1
- 1C3
- 1C4
- 7A2
- Aldose reductase
- Beta-Ketoacyl ACP reductase
- Carbohydrate dehydrogenases
- Carnitine dehydrogenase
- D-malate dehydrogenase (decarboxylating)
- DXP reductoisomerase
- Glucose-6-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase
- HMG-CoA reductase
- IMP dehydrogenase
- Isocitrate dehydrogenase
- Lactate dehydrogenase
- L-threonine dehydrogenase
- L-xylulose reductase
- Malate dehydrogenase
- Malate dehydrogenase (decarboxylating)
- Malate dehydrogenase (NADP+)
- Malate dehydrogenase (oxaloacetate-decarboxylating)
- Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
- Phosphogluconate dehydrogenase
- Sorbitol dehydrogenase
- Hydroxysteroid dehydrogenase: 3β
- 11β
- 17β
|
| 1.1.2: cytochrome acceptor |
- D-lactate dehydrogenase (cytochrome)
- D-lactate dehydrogenase (cytochrome c-553)
- Mannitol dehydrogenase (cytochrome)
|
| 1.1.3: oxygen acceptor |
- Glucose oxidase
- L-gulonolactone oxidase
- Xanthine oxidase
|
| 1.1.4: disulfide as acceptor |
- Vitamin K epoxide reductase
- Vitamin-K-epoxide reductase (warfarin-insensitive)
|
| 1.1.5: quinone/similar acceptor |
- Malate dehydrogenase (quinone)
- Quinoprotein glucose dehydrogenase
|
| 1.1.99: other acceptors |
- Choline dehydrogenase
- L2HGDH
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- Global Analysis of Mannitol 2-Dehydrogenase in Lactobacillus reuteri CRL 1101 during Mannitol Production through Enzymatic, Genetic and Proteomic Approaches.
- Ortiz ME1, Bleckwedel J1, Fadda S1, Picariello G2, Hebert EM1, Raya RR1, Mozzi F1.
- PloS one.PLoS One.2017 Jan 6;12(1):e0169441. doi: 10.1371/journal.pone.0169441. eCollection 2017.
- Several plants, fungi, algae, and certain bacteria produce mannitol, a polyol derived from fructose. Mannitol has multiple industrial applications in the food, pharmaceutical, and medical industries, being mainly used as a non-metabolizable sweetener in foods. Many heterofermentative lactic acid bac
- PMID 28060932
- Controlled Orientation of Active Sites in a Nanostructured Multienzyme Complex.
- Lim SI1, Yang B2, Jung Y2, Cha J2, Cho J2, Choi ES2,3, Kim YH4, Kwon I1,2.
- Scientific reports.Sci Rep.2016 Dec 22;6:39587. doi: 10.1038/srep39587.
- Multistep cascade reactions in nature maximize reaction efficiency by co-assembling related enzymes. Such organization facilitates the processing of intermediates by downstream enzymes. Previously, the studies on multienzyme nanocomplexes assembled on DNA scaffolds demonstrated that closer interenzy
- PMID 28004799
- Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803.
- Du W1, Angermayr SA1, Jongbloets JA1, Molenaar D2, Bachmann H2, Hellingwerf KJ1, Branco Dos Santos F1.
- ACS synthetic biology.ACS Synth Biol.2016 Dec 12. [Epub ahead of print]
- Cyanobacteria are mostly engineered to be sustainable cell-factories by genetic manipulations alone. Here, by modulating the concentration of allosteric effectors, we focus on increasing product formation without further burdening the cells with increased expression of enzymes. Resorting to a novel
- PMID 27936615
Japanese Journal
- Hydrogen peroxide generated by xanthine/xanthine oxidase system represses the proliferation of colorectal cancer cell line Caco-2
- Sakuma Satoru,Abe Muneyuki,Kohda Tetsuya,Fujimoto Yohko
- Journal of Clinical Biochemistry and Nutrition 56(1), 15-19, 2015
- … Experiments utilizing reactive oxygen species scavengers (superoxide dismutase, catalase and mannitol) and exogenous hydrogen peroxide revealed a major role of hydrogen peroxide in the xanthine/xanthine oxidase effect. … Investigations utilizing annexin V-fluorescein/PI assay using flow cytometry, and the lactate dehydrogenase extracellular release assay indicated that hydrogen peroxide induced necrosis, but not apoptosis, in Caco-2 cells. …
- NAID 130004879361
- Hydrogen peroxide generated by xanthine/xanthine oxidase system represses the proliferation of colorectal cancer cell line Caco-2
- Sakuma Satoru,Abe Muneyuki,Kohda Tetsuya,Fujimoto Yohko
- Journal of Clinical Biochemistry and Nutrition, 2015
- … Experiments utilizing reactive oxygen species scavengers (superoxide dismutase, catalase and mannitol) and exogenous hydrogen peroxide revealed a major role of hydrogen peroxide in the xanthine/xanthine oxidase effect. … Investigations utilizing annexin V-fluorescein/PI assay using flow cytometry, and the lactate dehydrogenase extracellular release assay indicated that hydrogen peroxide induced necrosis, but not apoptosis, in Caco-2 cells. …
- NAID 130004704979
- Construction of an efficient Escherichia coli whole-cell biocatalyst for D-mannitol production(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Reshamwala Shamlan M.S.,Pagar Sandip K.,Velhal Vishal S. [他],Maranholakar Vijay M.,Talangkar Vishal G.,Lali Arvind M.
- Journal of bioscience and bioengineering 118(6), 628-631, 2014-12
- … Mannitol is a six carbon sugar alcohol that finds applications in the pharmaceutical and food industries. … A novel Escherichia coli strain capable of converting D-glucose to D-mannitol has been constructed, wherein native mannitol-1-phosphate dehydrogenase (MtlD) and codon-optimized Eimeria tenella mannitol-1-phosphatase (M1Pase) have been overexpressed. …
- NAID 110009900845
Related Links
- Cloning and Characterization of NADP-Mannitol Dehydrogenase cDNA from the Button Mushroom, Agaricus bisporus, and Its Expression in Response to NaCl Stress ... Mannitol, a six-carbon sugar alcohol, is the main storage ...
- Oxidizes mannitol to mannose. Provides the initial step by which translocated mannitol is committed to central metabolism and, by regulating mannitol pool size, is important in regulating salt tolerance at the cellular level.
★リンクテーブル★
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- 英
- mannitol dehydrogenase
- 関
- マンニトールデヒドロゲナーゼ
[★]
- 英
- mannitol dehydrogenase
- 関
- マンニトール脱水素酵素
[★]
脱水素酵素 デヒドロゲナーゼ
[★]
脱水素酵素 デヒドロゲナーゼ