マフェニド。酢酸マフェニド
WordNet
- a salt or ester of acetic acid (同)ethanoate
PrepTutorEJDIC
- 酢酸(さくさん)塩;アセテート(酢酸人造絹糸)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/05/24 07:57:08」(JST)
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Mafenide
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Clinical data |
Trade names |
Sulfamylon |
AHFS/Drugs.com |
Monograph |
Routes of
administration |
Topical |
ATC code |
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Legal status |
Legal status |
- In general: ℞ (Prescription only)
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Identifiers |
IUPAC name
- 4-(Aminomethyl)benzenesulfonamide
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CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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KEGG |
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ChEMBL |
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ECHA InfoCard |
100.004.843 |
Chemical and physical data |
Formula |
C7H10N2O2S |
Molar mass |
186.233 g/mol |
3D model (Jmol) |
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InChI
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InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) Y
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Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N Y
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NY (what is this?) (verify) |
Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.
Contents
- 1 Uses
- 2 Mechanism of action
- 3 Adverse reactions
- 4 Drug interactions
- 5 Contraindications
- 6 Dosage
- 7 References
- 8 External links
Uses
Mafenide is used to treat severe burns.[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.[3]
Mechanism of action
Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.
Adverse reactions
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Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.
Drug interactions
There are no significant interactions.
Contraindications
Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.
Dosage
For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.
References
- ^ Siuda J. F.; Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670.
- ^ Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England J. Medic. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444.
- ^ Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns. 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581.
External links
- Mafenide information on RxList
Antibiotics and chemotherapeutics for dermatological use (D06)
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Antibiotics |
Tetracycline and derivatives
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- Demeclocycline
- Chlortetracycline
- Oxytetracycline
- Tetracycline
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Others
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- Amphenicol: Chloramphenicol
- Aminoglycosides: Neomycin
- Gentamicin
- Amikacin
- Streptogramin: Virginiamycin
- other: Fusidic acid
- Bacitracin
- Tyrothricin
- Mupirocin
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Chemotherapeutics |
Sulfonamides
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- Silver sulfadiazine
- Sulfathiazole
- Mafenide
- Sulfamethizole
- Sulfanilamide
- Sulfamerazine
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Antivirals
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- Aciclovir
- Penciclovir
- Idoxuridine
- Edoxudine
- Imiquimod
- Resiquimod
- Podophyllotoxin
- Docosanol
- Tromantadine
- Inosine
- Lysozyme
- Ibacitabine
- Lysine
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Other
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- Ingenol mebutate
- Metronidazole
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Antibacterials: nucleic acid inhibitors (J01E, J01M)
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Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
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Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
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Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
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Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
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Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
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Combinations |
- Trimethoprim/sulfamethoxazole#
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Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
1st g. |
- Cinoxacin‡
- Flumequine‡
- Nalidixic acid‡
- Oxolinic acid‡
- Pipemidic acid‡
- Piromidic acid‡
- Rosoxacin‡
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Fluoro-
quinolones |
2nd g. |
- Ciprofloxacin#
- Ofloxacin
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin‡
- Nadifloxacin‡
- Norfloxacin‡
- Pefloxacin‡
- Rufloxacin‡
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3rd g. |
- Levofloxacin#
- Balofloxacin‡
- Grepafloxacin‡
- Pazufloxacin‡
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin‡
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4th g. |
- Besifloxacin
- Gatifloxacin
- Finafloxacin
- Gemifloxacin
- Moxifloxacin
- Clinafloxacin†
- Garenoxacin‡
- Prulifloxacin‡
- Sitafloxacin‡
- Trovafloxacin‡/Alatrofloxacin‡
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Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
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Newer non-fluorinated |
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Related (DG) |
- Aminocoumarins: Novobiocin
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Anaerobic DNA
inhibitors |
Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
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Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
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RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin#
- Rifapentine#
- Rifaximin
- Rifalazil§
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- Purification and characterization of carbonic anhydrase from Ağrı Balık Lake trout gill (Salmo trutta labrax) and effects of sulfonamides on enzyme activity.
- Demirdag R1, Comakli V, Kuzu M, Yerlikaya E, Şentürk M.
- Journal of biochemical and molecular toxicology.J Biochem Mol Toxicol.2015 Mar;29(3):123-8. doi: 10.1002/jbt.21675. Epub 2014 Oct 26.
- Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using s
- PMID 25345690
- Antibiotic eluting clay mineral (Laponite®) for wound healing application: an in vitro study.
- Ghadiri M1, Chrzanowski W, Rohanizadeh R.
- Journal of materials science. Materials in medicine.J Mater Sci Mater Med.2014 Nov;25(11):2513-26. doi: 10.1007/s10856-014-5272-7. Epub 2014 Jul 16.
- Different materials in form of sponge, hydrogel and film have been developed and formulated for treating and dressing burn wounds. In this study, the potential of Laponite, a gel forming clay, in combination with an antimicrobial agent (mafenide), as a wound dressing material was tested in vitro. La
- PMID 25027303
- FDA's post-approval studies continue to suffer delays and setbacks.
- Willyard C.
- Nature medicine.Nat Med.2014 Nov;20(11):1224-5. doi: 10.1038/nm1114-1224.
- PMID 25375913
Japanese Journal
- Differential inhibition of human basal keratinocyte growth to silver sulfadiazine and mafenide acetate
- 各種抗菌剤の臨床分離緑のう菌に対する抗菌力 熱傷創分離緑のう菌と非熱傷創分離緑のう菌の比較:熱傷創分離緑膿菌と非熱傷創分離緑膿菌の比較
- 小野 一郎,大浦 武彦,吉田 哲憲,松本 敏明,浅見 謙二,本田 耕一,飯田 和典,佐藤 清
- CHEMOTHERAPY 32(7), 439-448, 1984
- 今回, 我々は当科ならびに当科関連施設において分離された熱傷創分離緑膿菌50株と非熱傷創分離緑膿菌50株の計100株の臨床分離緑膿菌について, 血清型を決定するとともに, 各種抗生物質と酢酸マフェニド, シルパーサルファジアジンの最小発育阻止濃度 (MIC) を日本化学療法学会標準法により検討を加えた。<BR>その結果, 臨床分離緑膿菌に対する各種抗菌剤のMICのpeakはDKBとCF …
- NAID 130004194306
- 熱傷受傷時における肺変化に関する病理学的研究:(II) 実験的熱傷時における肺変化に関する超微形態学的研究
- 久野 佑三
- 日本医科大学雑誌 46(1), 45-50_6, 1979
- … Preventions of the infections and subsequent septic shock with Gramnegative bacilli have been achieved by virtue of silver sulfadiazine or mafenide acetate cream. … The second group was treated topically with mafenide acetate cream once a day or more. … An observation was made after uranyl acetate and lead hydroxide double stain, Dermer's tricornplex flocculation method, ruthenium red and PAM staining procedures. …
- NAID 130003917825
Related Links
- Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide. ... Mafenide (Sulfamylon) can interfere with the kidney's role in hydrogen ion excretion, resulting in metabolic acidosis. Mafenide is a topical sulfonamide ...
- 17 Jul 2008 ... Learn about the prescription medication Sulfamylon (Mafenide Acetate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
★リンクテーブル★
[★]
- 英
- mafenide
- 化
- 酢酸マフェニド mafenide acetate
- 同
- マフェナイド
- 商
- Sulfamylon
[★]
マフェニド、マフェナイド