マフェニド、マフェナイド
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/19 21:18:26」(JST)
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Mafenide
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Systematic (IUPAC) name |
4-(aminomethyl)benzenesulfonamide |
Clinical data |
AHFS/Drugs.com |
monograph |
Legal status |
? |
Routes |
Topical |
Identifiers |
CAS number |
138-39-6 N |
ATC code |
D06BA03 |
PubChem |
CID 3998 |
ChemSpider |
3858 Y |
UNII |
58447S8P4L Y |
KEGG |
D02351 Y |
ChEMBL |
CHEMBL419 Y |
Chemical data |
Formula |
C7H10N2O2S |
Mol. mass |
186.233 g/mol |
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InChI
-
InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) Y
Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N Y
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N (what is this?) (verify) |
Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication. It was approved by the FDA in 1948.
Contents
- 1 Uses
- 2 Mechanism of Action
- 3 Adverse Reactions
- 4 Drug interactions
- 5 Contraindications
- 6 Dosage
- 7 See also
- 8 References
- 9 External links
Uses[edit]
It is used to treat severe burns.[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.[3]
Mechanism of Action[edit]
Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.
Adverse Reactions[edit]
Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.
Drug interactions[edit]
There are no significant interactions.
Contraindications[edit]
Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.
Dosage[edit]
For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.
See also[edit]
References[edit]
- ^ Siuda J. F., Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670.
- ^ Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England J. Medic. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444.
- ^ Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581.
External links[edit]
- Mafenide information on RxList
Antibiotics and chemotherapeutics for dermatological use (D06)
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Antibiotics |
Tetracycline and derivatives
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- Demeclocycline
- Chlortetracycline
- Oxytetracycline
- Tetracycline
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Others
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- Amphenicol: Chloramphenicol
- Aminoglycosides: Neomycin
- Gentamicin
- Amikacin
- Streptogramin: Virginiamycin
- other: Fusidic acid
- Bacitracin
- Tyrothricin
- Mupirocin
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Chemotherapeutics |
Sulfonamides
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- Silver sulfadiazine
- Sulfathiazole
- Mafenide
- Sulfamethizole
- Sulfanilamide
- Sulfamerazine
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Antivirals
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- Aciclovir
- Penciclovir
- Idoxuridine
- Edoxudine
- Imiquimod/Resiquimod
- Podophyllotoxin
Docosanol
- Tromantadine
- Inosine
- Lysozyme
- Ibacitabine
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Other
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- Ingenol mebutate
- Metronidazole
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noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon
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proc, drug (D2/3/4/5/8/11)
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Antibacterials: nucleic acid inhibitors (J01E, J01M)
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Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
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Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
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Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
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Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
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Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
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Combinations |
- Trimethoprim/sulfamethoxazole#
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Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
1st g. |
- Cinoxacin‡
- Flumequine
- Nalidixic acid
- Oxolinic acid
- Pipemidic acid
- Piromidic acid
- Rosoxacin
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Fluoro-
quinolones |
2nd g. |
- Ciprofloxacin#
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin
- Nadifloxacin
- Ofloxacin
- Norfloxacin
- Pefloxacin
- Rufloxacin
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3rd g. |
- Balofloxacin
- Grepafloxacin‡
- Levofloxacin
- Pazufloxacin
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin
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4th g. |
- Besifloxacin
- Clinafloxacin†
- Garenoxacin
- Gemifloxacin
- Moxifloxacin
- Gatifloxacin‡
- Sitafloxacin
- Trovafloxacin‡/Alatrofloxacin‡
- Prulifloxacin
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Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
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Related (DG) |
- Aminocoumarins: Novobiocin
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Anaerobic DNA
inhibitors |
Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
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Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
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RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a (t)/gr-p (c)/gr-o
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drug (J1p, w, n, m, vacc)
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UpToDate Contents
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English Journal
- Purification and characterization of carbonic anhydrase from Ağrı Balık Lake trout gill (Salmo trutta labrax) and effects of sulfonamides on enzyme activity.
- Demirdag R1, Comakli V, Kuzu M, Yerlikaya E, Şentürk M.
- Journal of biochemical and molecular toxicology.J Biochem Mol Toxicol.2015 Mar;29(3):123-8. doi: 10.1002/jbt.21675. Epub 2014 Oct 26.
- Carbonic anhydrase (CA) was purified from Ağrı Balık Lake trout gill (fCA) by affinity chromatography on a sepharose 4B-tyrosine-sulfanilamide column. The fCA enzyme was purified with about a 303.9 purification factor, a specific activity 4130.4 EU (mg-protein)(-1), and a yield of 79.3 by using s
- PMID 25345690
- Antibiotic eluting clay mineral (Laponite®) for wound healing application: an in vitro study.
- Ghadiri M1, Chrzanowski W, Rohanizadeh R.
- Journal of materials science. Materials in medicine.J Mater Sci Mater Med.2014 Nov;25(11):2513-26. doi: 10.1007/s10856-014-5272-7. Epub 2014 Jul 16.
- Different materials in form of sponge, hydrogel and film have been developed and formulated for treating and dressing burn wounds. In this study, the potential of Laponite, a gel forming clay, in combination with an antimicrobial agent (mafenide), as a wound dressing material was tested in vitro. La
- PMID 25027303
- FDA's post-approval studies continue to suffer delays and setbacks.
- Willyard C.
- Nature medicine.Nat Med.2014 Nov;20(11):1224-5. doi: 10.1038/nm1114-1224.
- PMID 25375913
Japanese Journal
- Differential inhibition of human basal keratinocyte growth to silver sulfadiazine and mafenide acetate
- :<I>AERUGINOSA</I> ISOLATED FROM CLINICAL MATERIALS
- 小野 一郎,大浦 武彦,吉田 哲憲,松本 敏明,浅見 謙二,本田 耕一,飯田 和典,佐藤 清
- CHEMOTHERAPY 32(7), 439-448, 1984
- … The peaks of minimum inhibitory concentrations (MIC) distributions were as follows, in dibecacin and cefsulodin were at 1.56μg/ml, in gentamicin and amikacin were at 6.25μg/ml, in silver sulfadiazine and sulbenicillin were at 25μg/ml and in mafenide acetate was at 200μg/ml. …
- NAID 130004194306
- An ultrastructural study of the alveolar cells of the lung:in experimentally induced severe thermal burns
- 久野 佑三
- 日本医科大学雑誌 46(1), 45-50_6, 1979
- … Preventions of the infections and subsequent septic shock with Gramnegative bacilli have been achieved by virtue of silver sulfadiazine or mafenide acetate cream. … The second group was treated topically with mafenide acetate cream once a day or more. …
- NAID 130003917825
Related Links
- Mafenide definition, an antibacterial substance, C 7 H 1 0 N 2 O 2 S, prepared in cream form and used topically, along with other treatments, on second- to third-degree burns to reduce bacterial growth. See more. Thesaurus Blog ...
- mafenide [maf´en-īd] a compound used in the form of the acetate and hydrochloride salts for topical treatment of infections. mafenide /maf·en·ide/ (maf´in-īd) an antibacterial, used topically as the monoacetate salt in superficial ...
★リンクテーブル★
[★]
- 英
- mafenide
- 化
- 酢酸マフェニド mafenide acetate
- 同
- マフェナイド
- 商
- Sulfamylon
[★]
マフェニド。酢酸マフェニド