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- mabuterol hydrochloride
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/25 22:15:59」(JST)
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Mabuterol
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Names |
IUPAC name
(RS)-1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol
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Identifiers |
CAS Number
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56341-08-3 N |
ChEMBL |
ChEMBL86749 Y |
ChemSpider |
3857 Y |
Jmol 3D model |
Interactive image |
MeSH |
mabuterol |
PubChem |
3995 |
UNII |
R4K19W6S7Q Y |
InChI
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InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3 Y
Key: JSJCTEKTBOKRST-UHFFFAOYSA-N Y
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InChI=1/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3
Key: JSJCTEKTBOKRST-UHFFFAOYAW
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SMILES
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Clc1cc(cc(c1N)C(F)(F)F)C(O)CNC(C)(C)C
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Properties |
Chemical formula
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C13H18ClF3N2O |
Molar mass |
310.74 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is YN ?) |
Infobox references |
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Mabuterol is a selective β2 adrenoreceptor agonist.[1][2]
References
- ^ Osada, E; Murai, T; Ishizaka, Y; Sanai, K (1984). "Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs.". Arzneimittel-Forschung 34 (11A): 1641–51. PMID 6152157.
- ^ Akahane K, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S (July 1989). "Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog". Br. J. Pharmacol. 97 (3): 709–16. doi:10.1111/j.1476-5381.1989.tb12007.x. PMC 1854580. PMID 2474351.
Adrenergics
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Receptor ligands
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α1 |
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- Urapidil
- WB-4101
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α2 |
- Agonists
- (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
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- Brimonidine
- Cannabivarin
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- Oxymetazoline
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- Tetrahydrozoline
- Tiamenidine
- Tizanidine
- Tolonidine
- Urapidil
- Xylazine
- Xylometazoline
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- Antagonists
- 1-PP
- Adimolol
- Aptazapine
- Atipamezole
- Atypical antipsychotics (e.g., asenapine, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine)
- Azapirones (e.g., buspirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Olanzapine
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- SB-269970
- Setiptiline
- Spiroxatrine
- Sunepitron
- Tolazoline
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
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β |
- Agonists
- Abediterol
- Alifedrine
- Amibegron
- Arbutamine
- Arformoterol
- Arotinolol
- BAAM
- Bambuterol
- Befunolol
- Bitolterol
- Broxaterol
- Buphenine
- Carbuterol
- Carmoterol
- Cimaterol
- Clenbuterol
- Corbadrine
- Denopamine
- Dipivefrine
- Dobutamine
- Dopamine
- Dopexamine
- Ephedrine
- Epinephrine
- Etafedrine
- Etilefrine
- Ethylnorepinephrine
- Fenoterol
- Formoterol
- Hexoprenaline
- Higenamine
- Indacaterol
- Isoetarine
- Isoprenaline
- Isoxsuprine
- Levosalbutamol
- Mabuterol
- Methoxyphenamine
- Methyldopa
- Mirabegron
- Norepinephrine
- Orciprenaline
- Oxyfedrine
- PF-610355
- Phenylpropanolamine
- Pirbuterol
- Prenalterol
- Ractopamine
- Procaterol
- Pseudoephedrine
- Reproterol
- Rimiterol
- Ritodrine
- Salbutamol
- Salmeterol
- Solabegron
- Terbutaline
- Tretoquinol
- Tulobuterol
- Vilanterol
- Xamoterol
- Zilpaterol
- Zinterol
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- Antagonists
- Acebutolol
- Adaprolol
- Adimolol
- Afurolol
- Alprenolol
- Alprenoxime
- Amosulalol
- Ancarolol
- Arnolol
- Arotinolol
- Atenolol
- Befunolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Bopindolol
- Bornaprolol
- Brefonalol
- Bucindolol
- Bucumolol
- Bufetolol
- Bufuralol
- Bunitrolol
- Bunolol
- Bupranolol
- Butaxamine
- Butidrine
- Butofilolol
- Capsinolol
- Carazolol
- Carpindolol
- Carteolol
- Carvedilol
- Celiprolol
- Cetamolol
- Cicloprolol
- Cinamolol
- Cloranolol
- Cyanopindolol
- Dalbraminol
- Dexpropranolol
- Diacetolol
- Dichloroisoprenaline
- Dihydroalprenolol
- Dilevalol
- Diprafenone
- Draquinolol
- Ecastolol
- Epanolol
- Ericolol
- Ersentilide
- Esatenolol
- Esprolol
- Eugenodilol
- Exaprolol
- Falintolol
- Flestolol
- Flusoxolol
- Hydroxycarteolol
- Hydroxytertatolol
- ICI-118,551
- Idropranolol
- Indenolol
- Indopanolol
- Iodocyanopindolol
- Iprocrolol
- Isoxaprolol
- Isamoltane
- Labetalol
- Landiolol
- Levobetaxolol
- Levobunolol
- Levomoprolol
- Medroxalol
- Mepindolol
- Metipranolol
- Metoprolol
- Moprolol
- Nadolol
- Nadoxolol
- Nebivolol
- Nifenalol
- Nipradilol
- Oxprenolol
- Pacrinolol
- Pafenolol
- Pamatolol
- Pargolol
- Penbutolol
- Pindolol
- Practolol
- Primidolol
- Procinolol
- Pronethalol
- Propafenone
- Propranolol
- Ridazolol
- Ronactolol
- Soquinolol
- Sotalol
- Spirendolol
- SR 59230A
- Sulfinalol
- Talinolol
- Tazolol
- Tertatolol
- Tienoxolol
- Tilisolol
- Timolol
- Tiprenolol
- Tolamolol
- Toliprolol
- Xibenolol
- Xipranolol
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Reuptake inhibitors
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NET |
- Selective norepinephrine reuptake inhibitors
- Amedalin
- Ciclazindol
- Daledalin
- Edivoxetine
- Esreboxetine
- Lortalamine
- Mazindol
- Nisoxetine
- Reboxetine
- Talopram
- Talsupram
- Tandamine
- Viloxazine
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- Norepinephrine-dopamine reuptake inhibitors
- Amineptine
- Bupropion
- Fencamine
- Fencamfamine
- Hydroxybupropion
- Lefetamine
- Levophacetoperane
- LR-5182
- Manifaxine
- Methylphenidate
- Nomifensine
- O-2172
- Radafaxine
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- Serotonin-norepinephrine reuptake inhibitors
- Atomoxetine (tomoxetine)
- Bicifadine
- BTS-54505
- Desvenlafaxine
- Duloxetine
- Eclanamine
- Levomilnacipran
- McN-5652
- Milnacipran
- N-Methyl-PPPA
- PPPA
- Sibutramine
- Venlafaxine
- WY-45233
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- Serotonin-norepinephrine-dopamine reuptake inhibitors
- (S)-Duloxetine
- 3,3-Diphenylcyclobutanamine
- Amifitadine
- Ansofaxine
- Bicifadine
- Brasofensine
- Centanafadine
- Cocaine
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- Diclofensine
- DOV-102677
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- NS-2359
- Perafensine
- PRC200
- SEP-228431
- SEP-228432
- Tedatioxetine
- Tesofensine
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- Tricyclic antidepressants
- Amitriptyline
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- Cianopramine
- Clomipramine
- Desipramine
- Dosulepin
- Doxepin
- Imipramine
- Lofepramine
- Melitracen
- Nortriptyline
- Protriptyline
- Trimipramine
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- Tetracyclic antidepressants
- Amoxapine
- Maprotiline
- Mianserin
- Oxaprotiline
- Setiptiline
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- Others
- Antihistamines (e.g., brompheniramine, chlorphenamine, pheniramine, tripelennamine)
- Arylcyclohexylamines (e.g., ketamine, phencyclidine)
- CP-39,332
- EXP-561
- Fezolamine
- Ginkgo biloba
- Indeloxazine
- Loxapine
- Nefazodone
- Nefopam
- Opioids (e.g., methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)
- Pridefine
- Tedatioxetine
- Teniloxazine
- Tofenacin
- Tropanes (e.g., cocaine)
- Ziprasidone
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VMATs |
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- Bietaserpine
- Deserpidine
- Efavirenz
- GBR-12935
- Ibogaine
- Ketanserin
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- Reserpine
- Rose bengal
- Tetrabenazine
- Vanoxerine (GBR-12909)
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Releasing agents
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- Morpholines
- Fenbutrazate
- Fenmetramide
- Morazone
- Morforex
- Phendimetrazine
- Phenmetrazine
- Pseudophenmetrazine
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- Oxazolines
- 4-MAR
- Aminorex
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- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone
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- Phenethylamines (also amphetamines, cathinones, etc)
- 2-OH-PEA
- 4-CAB
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- Etilamfetamine
- Famprofazone
- Fenethylline
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- Flephedrone
- Fludorex
- Furfenorex
- Hordenine
- 4-Hydroxyamphetamine
- 5-APDI (IAP)
- 5-MAPDI (IMP)
- Iofetamine (123I)
- Lisdexamfetamine
- Lophophine
- MBDB
- MDA
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- MDMA
- Metamfepramone
- MDMPEA
- MDOH
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- Mefenorex
- Mephedrone
- Mephentermine
- Methamphetamine
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- Methcathinone
- Methedrone
- Methylone
- Morforex
- Naphthylaminopropane
- Ortetamine
- pBA
- pCA
- Pentorex
- Phenethylamine
- Pholedrine
- Phenpromethamine
- Phentermine
- Phenylpropanolamine
- pIA
- Prenylamine
- Propylamphetamine
- Pseudoephedrine
- Selegiline (also D-Deprenyl)
- Tiflorex
- Tyramine
- Xylopropamine
- Zylofuramine
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- Piperazines
- 2C-B-BZP
- BZP
- MBZP
- mCPP
- MDBZP
- MeOPP
- pFPP
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- Others
- 2-ADN
- 2-AI
- 2-AT
- 2-BP
- 4-BP
- 5-IAI
- Clofenciclan
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Feprosidnine
- Gilutensin
- Heptaminol
- Hexacyclonate
- Indanorex
- Isometheptene
- Methylhexanamine
- Octodrine
- Phthalimidopropiophenone
- Propylhexedrine (Levopropylhexedrine)
- Tuaminoheptane
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Enzyme inhibitors
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PAH |
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TH |
- 3-Iodotyrosine
- Aquayamycin
- Bulbocapnine
- Metirosine
- Oudenone
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AAAD |
- Benserazide
- Carbidopa
- DFMD
- Genistein
- Methyldopa
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DBH |
- Bupicomide
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Phenopicolinic acid
- Tropolone
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PNMT |
- CGS-19281A
- SKF-64139
- SKF-7698
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MAO |
- Nonselective
- Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine
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- MAO-A selective
- Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- CX157 (Tyrima)
- Eprobemide
- Esuprone
- Harmala alkaloids
- Harmine
- Harmaline
- Tetrahydroharmine
- Harman
- Methylene blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
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- MAO-B selective
- Ladostigil
- Lazabemide
- Milacemide
- Mofegiline
- Pargyline
- Rasagiline
- Safinamide
- Selegiline (also D-Deprenyl)
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COMT |
- Entacapone
- Nitecapone
- Tolcapone
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Others
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Precursors |
- L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) → Dopamine
- L-DOPS (Droxidopa)
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Cofactors |
- Ferrous Iron (Fe2+)
- S-Adenosyl-L-Methionine
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal Phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
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Neurotoxins |
- DSP-4
- Oxidopamine (6-OHDA)
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Others |
- Activity enhancers
- BPAP
- PPAP
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- Release blockers
- Bethanidine
- Bretylium
- Guanadrel
- Guanazodine
- Guanethidine
- Guanoxan
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- See also:
- Dopaminergics
- Melatonergics
- Serotonergics
- List of adrenergic drugs
|
English Journal
- Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search.
- Li T1, Cao J2, Li Z2, Wang X1, He P3.
- Food chemistry.Food Chem.2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30.
- Broad screening and identification of β-agonists in feed, serum, urine, muscle and liver samples was achieved in a quick and highly sensitive manner using ultra high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) combined with a spect
- PMID 26304337
- Suppression of the increasing level of acetylcholine-stimulated intracellular Ca2+ in guinea pig airway smooth muscle cells by mabuterol.
- Song X1, Zhao C1, Dai C1, Ren Y1, An N1, Wen H1, Pan LI2, Cheng M2, Zhang Y1.
- Biomedical reports.Biomed Rep.2015 Nov;3(6):778-786. Epub 2015 Aug 4.
- The present study aimed to establish an effective method for the in vitro culture of guinea pig airway smooth muscle (ASM) cells, and also investigate the suppressive effect of mabuterol hydrochloride (Mab) on the increased level of intracellular Ca2+ in ASM cells induced with acetylcholine (Ach). T
- PMID 26623015
- Sulfonated polystyrene magnetic nanobeads coupled with immunochromatographic strip for clenbuterol determination in pork muscle.
- Wu K1, Guo L2, Xu W2, Xu H2, Aguilar ZP3, Xu G4, Lai W2, Xiong Y5, Wan Y2.
- Talanta.Talanta.2014 Nov;129:431-7. doi: 10.1016/j.talanta.2014.06.007. Epub 2014 Jun 14.
- A magnetic solid-phase extraction method (MSPE) was developed to pre-concentrate and cleanup clenbuterol (CLE) from pork muscle. Novel sulfonated polystyrene magnetic nanobeads (spMNBs) were synthesized via a one-pot emulsion copolymerization method by using divinylbenzene, styrene, and sodium styre
- PMID 25127616
Japanese Journal
- Multiresidue analysis of β_2-agonists in human and calf urine using multimodal solid-phase extraction and high-performance liquid chromatography with electrochemical detection
- Journal of chromatography. B, Biomedical sciences and applications 726(1), 149-156, 1999-04-16
- NAID 10024535711
- β_2-Adrenergic agonist residues : simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography-mass spectrometry
- Journal of chromatography. B, Biomedical sciences and applications 716(1), 366-370, 1998-09-25
- NAID 10024532378
- Quantitative multi-residue determination of β-agonists in bovine urine using on-line immunoaffinity extraction-coupled column packed capillary liquid chromatography-tandem mass spectrometry
- Journal of chromatography. B, Biomedical sciences and applications 691(2), 357-370, 1997-04-11
- NAID 10024513671
Related Links
- Mabuterol | C13H18ClF3N2O | CID 3995 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... Property ...
- 回答者: mabuterol 回答日時: 2018/10/16 12:05 C6 を含んで良いならば Range(Cells(6, 3), Cells(6, 3).end(xldown)) 0 件 通報する お探しのQ&Aが見つからない時は、教えて!gooで質問しましょう! 全カテゴリから検索 このカテゴリから ...
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