WordNet

a complex consisting of an organic base in association with hydrogen chloride

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1. Initial pharmacologic therapy of osteoarthritis
2. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
3. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
4. 慢性腎疾患における高リン血症の治療 treatment of hyperphosphatemia in chronic kidney disease
5. コーガン症候群 cogans syndrome

English Journal

Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog.

Akahane K1, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S.Author information 1Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.Abstract1. Effects of (+/-)-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.- butylamino-ethanol hydrochloride (mabuterol) on pacemaker activity and atrial contractility were investigated in the isolated and blood-perfused right atrium of the dog. 2. Mabuterol, injected into the sinus node artery of the isolated atrium, dose-dependently increased atrial rate and contractile force at doses of 0.01-10 nmol but the responses to over 10 nmol of mabuterol gradually decreased and mabuterol at higher doses induced biphasic cardiac responses, i.e., negative followed by positive cardiac responses. 3. The maximal increases in atrial rate and contractile force induced by mabuterol were 41.4% and 12.9%, respectively, of the maximal chronotropic and inotropic effects of isoprenaline. 4. Positive chronotropic and inotropic responses to mabuterol were dose-dependently inhibited by a selective beta 2-adrenoceptor antagonist, ICI 118,551. These responses were only slightly attenuated by atenolol. 5. Mabuterol (1-300 nmol) dose-dependently inhibited both dobutamine- and procaterol-induced positive chronotropic and inotropic responses. 6. These results indicate that mabuterol causes weak positive chronotropic and inotropic effects on the perfused canine right atrium by activating beta 2-adrenoceptors, and that higher concentrations non-selectively block both beta 1-and beta 2-adrenoceptors.
British journal of pharmacology.Br J Pharmacol.1989 Jul;97(3):709-16.
1. Effects of (+/-)-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.- butylamino-ethanol hydrochloride (mabuterol) on pacemaker activity and atrial contractility were investigated in the isolated and blood-perfused right atrium of the dog. 2. Mabuterol, injected into the sinus node artery of th
PMID 2474351

First clinical studies on mabuterol. A summarizing report.

Kawakami Y.AbstractIn a dose finding study, a total of 245 asthmatic patients were given a single dose of 30, 40, 50, 60, 70 and 80 micrograms of dl-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-etha nol hydrochloride (mabuterol). From the results, 50 micrograms of mabuterol proved to be the optimal single dose in terms of effectiveness and tolerability. In a multicenter comparative study, asthmatic patients were treated with 50 or 75 micrograms of mabuterol twice a day for 6 weeks. From the results, 50 micrograms of mabuterol twice a day proved to be optimally effective and tolerable.
Arzneimittel-Forschung.Arzneimittelforschung.1984;34(11A):1699-700.
In a dose finding study, a total of 245 asthmatic patients were given a single dose of 30, 40, 50, 60, 70 and 80 micrograms of dl-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-etha nol hydrochloride (mabuterol). From the results, 50 micrograms of mabuterol proved to be the optimal
PMID 6152166

Pilot clinical trial with a new beta 2-sympathomimetic bronchodilator, mabuterol.

Ulmer WT, Scholz HJ, Baines A.AbstractAn open pilot study was performed on 10 patients with chronic, reversible, obstructive lung disease and known good response to beta 2-bronchodilators. The effects of 40, 60 and 80 micrograms 1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) given orally and of 0.4 mg fenoterol (aerosol) were measured on airway resistance, thoracic gas volume, pulse rate and blood pressure. Side effects, ECG and laboratory values were recorded. Mabuterol was found to have a good, clinically useful, bronchodilating effect and to possess excellent tolerability at doses of 40-60 micrograms.
Arzneimittel-Forschung.Arzneimittelforschung.1984;34(11A):1697-8.
An open pilot study was performed on 10 patients with chronic, reversible, obstructive lung disease and known good response to beta 2-bronchodilators. The effects of 40, 60 and 80 micrograms 1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) given oral
PMID 6152165