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Long‑term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR‑mutant PC9 lung cancer cell line.

Terai H1, Soejima K1, Yasuda H1, Sato T1, Naoki K2, Ikemura S1, Arai D1, Ohgino K1, Ishioka K1, Hamamoto J1, Kanai Y3, Betsuyaku T1.
International journal of oncology.Int J Oncol.2015 Jan;46(1):430-6. doi: 10.3892/ijo.2014.2733. Epub 2014 Oct 29.
This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, whic
PMID 25353970

Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats.

Zhang Q1, Tan Y1, Zhang N1, Yao F2.
Molecular medicine reports.Mol Med Rep.2015 Jan;11(1):603-10. doi: 10.3892/mmr.2014.2708. Epub 2014 Oct 20.
The pathophysiology of non‑alcoholic fatty liver disease remains to be elucidated, and the currently available treatments are not entirely effective. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspi-datum, has previously been demonstrated to possess hepatoprotective eff
PMID 25333896

Is liver transplantation safe and effective in elderly (≥70 years) recipients? A case-controlled analysis.

Wilson GC1, Quillin RC 3rd, Wima K, Sutton JM, Hoehn RS, Hanseman DJ, Paquette IM, Paterno F, Woodle ES, Abbott DE, Shah SA.
HPB : the official journal of the International Hepato Pancreato Biliary Association.HPB (Oxford).2014 Dec;16(12):1088-94. doi: 10.1111/hpb.12312. Epub 2014 Aug 6.
BACKGROUND: Elderly patients are evaluated for liver transplantation (LT) with increasing frequency, but outcomes in this group have not been well defined.METHODS: A linkage of the Scientific Registry of Transplant Recipients (SRTR) and the University HealthSystem Consortium (UHC) databases identifi
PMID 25099347