ロムスチン
WordNet
- an antineoplastic drug often used to treat brain tumors or Hodgkins disease
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/04 19:45:49」(JST)
[Wiki en表示]
|
This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (November 2014) |
Lomustine
|
|
Systematic (IUPAC) name |
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
|
Clinical data |
Trade names |
CeeNU |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a682207 |
Pregnancy
category |
|
Routes of
administration |
Oral |
Legal status |
|
Pharmacokinetic data |
Bioavailability |
~100% |
Protein binding |
50% |
Metabolism |
hepatic |
Biological half-life |
16–48 hours |
Identifiers |
CAS Number |
13010-47-4 Y |
ATC code |
L01AD02 |
PubChem |
CID 3950 |
IUPHAR/BPS |
7214 |
DrugBank |
DB01206 Y |
ChemSpider |
3813 Y |
UNII |
7BRF0Z81KG Y |
KEGG |
D00363 Y |
ChEBI |
CHEBI:6520 N |
ChEMBL |
CHEMBL514 Y |
Synonyms |
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea |
Chemical data |
Formula |
C9H16ClN3O2 |
Molar mass |
233.695 g/mol |
|
InChI
-
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) Y
-
Key:GQYIWUVLTXOXAJ-UHFFFAOYSA-N Y
|
Physical data |
Melting point |
90 °C (194 °F) |
NY (what is this?) (verify) |
Lomustine (INN), also called 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (trade name CeeNU in the U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).
References
External links
- CeeNu (lomustine) Capsules data sheet published by the FDA
- Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
- Patient information at cancerbackup.org.uk
- DDB 29525
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Glioblastoma: patterns of recurrence and efficacy of salvage treatments.
- Oh J, Sahgal A, Sanghera P, Tsao MN, Davey P, Lam K, Symons S, Aviv R, Perry JR.SourceDivison of Neurology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.Can J Neurol Sci.2011 Jul;38(4):621-5.
- Background: It is controversial if distant recurrence of glioblastoma is more common after temozolomide (TMZ) concurrent with radiotherapy (RT). Optimal therapy for patients with recurrent disease after RT/TMZ is unclear. Our purpose was to evaluate recurrence patterns in glioblastoma and the effect
- PMID 21672702
- Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.
- Mokhtari K, Ducray F, Kros JM, Gorlia T, Idbaih A, Taphoorn M, Wesseling P, Hoang-Xuan K, Van den Bent M, Sanson M.SourceMixed Research Unit, UMR 975, INSERM, National Institute of Health and Medical Research-Pierre and Marie Curie University, Pitie-Salpetriere Group Hospital, Paris, France; R. Escourolle Laboratory of Neuropathology, Pitie-Salpetriere Group Hospital, Public Assistance Hospitals of Paris, APHP, Paris, France; Faculty of Medicine, Pierre and Marie Curie University, Paris, France.
- Cancer.Cancer.2011 Jul 1;117(13):3014-26. doi: 10.1002/cncr.25827. Epub 2011 Jan 18.
- BACKGROUND: Although it has been demonstrated that the neuronal intermediate filament alpha-internexin (INA) is closely related to 1p19q codeletion in gliomas, its prognostic and predictive value has not yet been confirmed in a prospective trial. The authors of this report assessed the prognostic si
- PMID 21246521
Japanese Journal
- Lomustine Loaded Chitosan Nanoparticles: Characterization and in-Vitro Cytotoxicity on Human Lung Cancer Cell Line L132
- Mehrotra Archana,Nagarwal Ramesh Chand,Pandit Jayanta Kumar
- CHEMICAL & PHARMACEUTICAL BULLETIN 59(3), 315-320, 2011
- … The aim of this work was to prepare chitosan nanoparticles loaded with antineoplastic drug Lomustine (LCNPs), by ionic-gelation method with homogenization. … LCNPs greatly inhibited the growth of the L132 cancer cell line used in this study in comparison to the native Lomustine (LMT). …
- NAID 130000648938
- ロムスチン抵抗性の犬皮膚型リンパ腫に対して放射線治療を実施した1例
- 佐藤 巌紀,西村 麻紀,三好 雅史,川本 恵子,古林 与志安,磯村 洋,宮原 和郎
- 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 63(9), 711-714, 2010-09-20
- NAID 10026611695
Related Links
- Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain ...
Related Pictures
★リンクテーブル★
[★]
- 英
- lomustine
- 同
- CCNU, CeeNu
- 関
- 抗悪性腫瘍薬、ニトロソウレア、カルムスチン、ニムスチン、ラニムスチン