WordNet

of or relating to or resembling a lobule
a small lobe or subdivision of a lobe
part of a compound leaf
interlobular veins of the kidney; receive blood from the arcuate vein and empty into the renal veins

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小葉;小裂片
(広告などの)ちらし,びら / (とじてない)パンフレット,小冊子 / 小さい(若)葉;(植物の複葉を構成する)小葉
球形の,球状の;小球体(粒)から成る

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/23 14:45:46」(JST)

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1. 異型および上皮内小葉癌：乳癌のハイリスク病変 atypia and lobular carcinoma in situ high risk lesions of the breast
2. 乳癌の病理 pathology of breast cancer
3. 乳房の発達および形態 breast development and morphology
4. 乳房温存療法 breast conserving therapy
5. 化膿性肉芽腫（小葉状毛細血管腫） pyogenic granuloma lobular capillary hemangioma

English Journal

Application of the QuantiFERON®-TB Gold test in erythema induratum.

Sim JH, Whang KU.Author information Department of Dermatology, College of Medicine, Soonchunhyang University , Seoul , South Korea.AbstractErythema induratum (EI) was originally described by Ernest Bazin in 1861 as nodular lesions on the legs in association with tuberculosis (TB). A 33-year-old woman was referred to our hospital with tender ulcerative nodules on her legs. Skin biopsies revealed lobular inflammation of the subcutaneous fat with vasculitis. Although conservative treatment was given, the lesions did not improve. Several months later as the lesions persisted, we suspected a TB infection and additional tests were performed. The chest roentgenogram results were normal. The skin biopsies were negative for acid-fast bacilli (AFB). Mycobacterial cultures of the blood and skin were negative. However, the QuantiFERON®-TB Gold test was positive, which led to a diagnosis of latent TB infection being made. The patient was treated with multidrug antituberculosis therapy, which successfully resolved her skin lesions. Therefore, reported herein is the application of the QuantiFERON®-TB Gold test for the confirmation of latent TB infection in EI patients.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Jun;25(3):260-3. doi: 10.3109/09546634.2012.699178. Epub 2012 Sep 19.
Erythema induratum (EI) was originally described by Ernest Bazin in 1861 as nodular lesions on the legs in association with tuberculosis (TB). A 33-year-old woman was referred to our hospital with tender ulcerative nodules on her legs. Skin biopsies revealed lobular inflammation of the subcutaneous
PMID 22920648

Key architectural changes in tumor-negative lymph nodes from metastatic-free oral cancer patients are valuable prognostic factors.

Vered M, Schiby G, Schnaiderman-Shapiro A, Novikov I, Bello IO, Salo T, Rytkönen A, Kauppila JH, Dobriyan A, Yahalom R, Taicher S, Dayan D.Author information Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Israel, lmy@netvision.net.il.AbstractRegional lymph node (LN) metastasis in oral cancer patients is the most significant grave prognostic factor. We evaluated the relationship between clinical outcomes and different histopathological changes in tumor-negative LNs (LN0) selected from neck dissections without metastatic disease (pN0). A total of 435 LN0 selected from pN0 neck dissections (up to three nodes in each level) were scored for histopathological parameters of LN areas, capsule thickness, subcapsular and medullary sinus ectasia, lobular architecture and percent of cortical reactive follicles. These were compared to 328 LN0 selected from neck dissections with metastases (pN+) after exclusion of metastatic LNs. Data were presented by maximum scores of each parameter in I-III (close) and in IV-V (distant) levels. Limited data from level V and regression analyses inferred that the values in level IV represented the worst changes for most patients. Cox proportional hazard regression on each parameter in close and distant levels demonstrated that capsule thickness, number of lobules and percent of reactive follicles were significantly associated with time to death from disease. The higher the change in distant levels, the shorter the time to death, while the higher the change in close levels (given a stable change in distant levels), the longer the time to death. After adjustment for gender, age and location, only the effect of the percent of reactive follicles retained their significant effect. Logistic regression of metastases demonstrated that all parameters except for percent of reactive follicles were significantly associated with risk of metastases, with differences between close and distant levels similar to those found for time to death. After adjustment for gender, age and location, only the area and number of lobes retained their significance. The findings of this study suggested that selective histopathological changes in tumor-negative LNs in metastatic-free patients provide new valuable prognostic parameters.
Clinical & experimental metastasis.Clin Exp Metastasis.2014 Mar;31(3):327-38. doi: 10.1007/s10585-013-9631-4. Epub 2014 Jan 7.
Regional lymph node (LN) metastasis in oral cancer patients is the most significant grave prognostic factor. We evaluated the relationship between clinical outcomes and different histopathological changes in tumor-negative LNs (LN0) selected from neck dissections without metastatic disease (pN0). A
PMID 24395336

The role of CD44+/CD24-/low biomarker for screening, diagnosis and monitoring of breast cancer.

Camerlingo R1, Ferraro GA2, De Francesco F2, Romano M3, Nicoletti G2, Di Bonito M4, Rinaldo M5, D'Andrea F2, Pirozzi G1.Author information 1Department of Experimental Oncology, National Cancer Institute, G. Pascale, Naples, Italy.2Department of Orthopedic, Traumatologic, Rehabilitative and Plastic-Reconstructive Sciences, Second University of Naples, Naples, Italy.3Department of Surgery, Oncology and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation, Padua University Hospital, Padua, Italy.4Department of Pathology, National Cancer Institute, G. Pascale, Naples, Italy.5Department of Senology, National Cancer Institute, G. Pascale, Naples, Italy.AbstractCancer stem cells (CSCs) have been defined as 'a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor'. The CSC hypothesis postulates that a small subpopulation of cancer cells drives tumor initiation, growth and metastasis. CSCs have been isolated from breast cancer using CD44+/CD24-/low phenotype. The purpose of the present study was to evaluate the expression of CD44+/CD24-/low in two diverse breast carcinomas (ductal and lobular), and to determine the correlation between expression of CD44+/CD24-/low, and clinicopathological characteristics starting from human fresh breast cancer specimens. We analyzed specimens from 57 patients using CD44 and CD24 markers by flow cytometry and immunohistochemistry and correlated the CD44+/CD24-/low phenotype with clinicopathological characteristics. Moreover, mammosphere formation was tested. In all specimens tested, CD44+/CD24-/low phenotype was detectable with mean percentage of 4.73% as confirmed also by immunohistochemical analyses. A significant statistical association was found among these phenotypic groups and age, grade G3, estrogen and progesterone receptor, Ki-67 as well as lymph node metastasis. No correlation was found for histological type. In conclusion, our data showed that CD44+/CD24-/low phenotype was found at a high frequency in tumors pT2, G3, pN3, positive for Ki-67, and negative for estrogen and progesterone receptors highlighting the hypothesis that CD44+/CD24-/low profile correlates with the more aggressive clinical-pathological features of the disease.
Oncology reports.Oncol Rep.2014 Mar;31(3):1127-32. doi: 10.3892/or.2013.2943. Epub 2013 Dec 23.
Cancer stem cells (CSCs) have been defined as 'a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor'. The CSC hypothesis postulates that a small subpopulation of cancer cells drives tumor initiation, growth an
PMID 24366074