WordNet

a polygenic disease characterized by abnormally high glucose levels in the blood; any of several metabolic disorders marked by excessive urination and persistent thirst

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/16 02:37:46」(JST)

Lipoatrophic diabetes is a type of diabetes mellitus presenting with severe lipodystrophy in addition to the traditional signs of diabetes.

Iglesias P, Alvarez Fidalgo P, Codoceo R, Díez J (2004). "Lipoatrophic diabetes in an elderly woman: clinical course and serum adipocytokine concentrations.". Endocr J 51 (3): 279–86. doi:10.1507/endocrj.51.279. PMID 15256772.
Morse A, Whitaker M (2000). "Successful pregnancy in a woman with lipoatrophic diabetes mellitus. A case report.". J Reprod Med 45 (10): 850–2. PMID 11077638.
Meyer L, Hadjadj S, Guerci B, Delbachian I, Ziegler O, Drouin P (1998). "Lipoatrophic diabetes mellitus treated by continuous subcutaneous insulin infusion.". Diabetes Metab 24 (6): 544–6. PMID 9932222.

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1. 糖尿病および遺伝的糖尿病症候群の分類 classification of diabetes mellitus and genetic diabetic syndromes
2. インスリン抵抗性：定義および臨床像 insulin resistance definition and clinical spectrum
3. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus
4. 成人における糖尿病に対する治療の概要 overview of medical care in adults with diabetes mellitus
5. 糖尿病性腎症の概要 overview of diabetic nephropathy

Seipin knockout impairs proliferation and differentiation of adult stem/progenitor cells in hippocampal dentate gyrus via reduction of PPARγ.

Li G1, Zhou L2, Zhu Y2, Wang C2, Sha S2, Xian X3, Ji Y4, Liu G5, Chen L6.
Disease models & mechanisms.Dis Model Mech.2015 Sep 22. pii: dmm.021550. [Epub ahead of print]
Seipin gene is originally identified as a loss-of-function gene for congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin knockout (seipin-nKO) mice display depression-like phenotype with reduction of hippocampal peroxisome proliferator-activated receptor gamma (PPARγ) level. The pres
PMID 26398946

Cortés VA1, Fernández-Galilea M.
Journal of physiology and biochemistry.J Physiol Biochem.2015 Sep;71(3):471-8. doi: 10.1007/s13105-015-0404-1. Epub 2015 Apr 2.
Lipodystrophy encompass a group of heterogeneous disorders consisting in marked reduction, absence, and/or the redistribution of adipose tissue. Lipodystrophy is frequently complicated with severe insulin resistance, diabetes, hyperlipidemia, and fatty liver. Anatomically, lipodystrophies can be par
PMID 25833179

Acquired partial lipodystrophy is associated with increased risk for developing metabolic abnormalities.

Akinci B1, Koseoglu FD2, Onay H3, Yavuz S4, Altay C5, Simsir IY6, Ozisik S7, Demir L8, Korkut M9, Yilmaz N10, Ozen S11, Akinci G12, Atik T3, Calan M7, Secil M5, Comlekci A7, Demir T7.
Metabolism: clinical and experimental.Metabolism.2015 Sep;64(9):1086-95. doi: 10.1016/j.metabol.2015.06.004. Epub 2015 Jun 10.
OBJECTIVE: Acquired partial lipodystrophy (APL) is a rare disorder characterized by progressive selective fat loss. In previous studies, metabolic abnormalities were reported to be relatively rare in APL, whilst they were quite common in other types of lipodystrophy syndromes.METHODS: In this nation
PMID 26139569