- 関
- adipose、lipid
WordNet
- composed of animal fat; "adipose tissue constitutes the fat of meat"
- an oily organic compound insoluble in water but soluble in organic solvents; essential structural component of living cells (along with proteins and carbohydrates) (同)lipide, lipoid
PrepTutorEJDIC
- 脂肪質の
- 脂質,あぶら
UpToDate Contents
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English Journal
- Apoptosis regulation at the mitochondrial outer membrane.
- Gillies LA, Kuwana T.Author information La Jolla Institute, La Jolla, California, 92037.AbstractMitochondria play a critical role in apoptosis, or programmed cell death, by releasing apoptogenic factors from the intermembrane space. This process, known as mitochondrial outer membrane permeabilization (MOMP), is tightly regulated by the Bcl-2 family proteins. Pro-apoptotic Bcl-2 family members, Bax and Bak, change their conformation when activated by BH3 domain-only proteins in the family and permeabilize the MOM, whereas pro-survival members inhibit permeabilization. The precise nature of the apoptotic pore in the MOM is unknown, but is probably lipidic. Furthermore, it has been realized that there is another layer of MOMP regulation by a protein factor termed the catalyst in the MOM in order for Bax/Bak to achieve efficient and complete membrane permeabilization. Mitochondrial dynamics do not affect MOMP directly, but seem closely coordinated with MOMP for swift protein efflux from mitochondria. This review will present current views on the molecular mechanisms and regulation of MOMP and conclude with recent developments in clinical applications based on the knowledge gleaned from the investigation. J. Cell. Biochem. 115: 632-640, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular biochemistry.J Cell Biochem.2014 Apr;115(4):632-40. doi: 10.1002/jcb.24709.
- Mitochondria play a critical role in apoptosis, or programmed cell death, by releasing apoptogenic factors from the intermembrane space. This process, known as mitochondrial outer membrane permeabilization (MOMP), is tightly regulated by the Bcl-2 family proteins. Pro-apoptotic Bcl-2 family members,
- PMID 24453042
- Reconstitution of OmpF membrane protein on bended lipid bilayers: perforated hexagonal mesophases.
- Zabara A, Negrini R, Baumann P, Onaca-Fischer O, Mezzenga R.Author information Food & Soft Material Science, Institute of Food Nutrition and Health, ETH Zurich, Schmelzbergstrasse 9, LFO E23, 8092, Zurich, Switzerland. raffaele.mezzenga@hest.ethz.ch.AbstractMembrane proteins have been reconstituted on lipid bilayers with zero mean-curvature (cubic phases or vesicles). Here we show that reconstitution of pore-forming membrane proteins can also occur on highly curved lipidic bilayers of reverse hexagonal mesophases, for which the mean-curvature is significantly different from zero. We further show that the membrane protein provides unique topological interconnectivities between the aqueous nanochannels, significantly enhancing mesophase transport properties.
- Chemical communications (Cambridge, England).Chem Commun (Camb).2014 Jan 28. [Epub ahead of print]
- Membrane proteins have been reconstituted on lipid bilayers with zero mean-curvature (cubic phases or vesicles). Here we show that reconstitution of pore-forming membrane proteins can also occur on highly curved lipidic bilayers of reverse hexagonal mesophases, for which the mean-curvature is signif
- PMID 24469110
- Lipid charge regulation of non-specific biological ion channels.
- Aguilella VM, Verdiá-Báguena C, Alcaraz A.Author information Dept. Physics, Lab. Molecular Biophysics, Universitat Jaume I, 12080 Castellón, Spain. aguilell@uji.es.AbstractIon channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charges configure a polarized interface that yields local ionic concentrations and electric potentials that are very different from those of the bulk electrolyte. The combined effect of gradients of ionic concentration and electric potential causes the transport of ions through channels. Here we analyze charge regulation effects in different protein-lipid conformations, stressing how important is the role of electrostatic interactions in the ion channel function that traditionally has been rationalized paying attention mainly to changes in pore size. Tuning lipid charge combined with conductance and selectivity measurements is shown to be a complementary method to evidence lipid involvement in the structure of a biological ion channel.
- Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2014 Jan 23. [Epub ahead of print]
- Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charg
- PMID 24452437
Japanese Journal
- Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems
- iMap-Intravascular Ultrasound Radiofrequency Signal Analysis Reflects Plaque Components of Optical Coherence Tomography-Derived Thin-Cap Fibroatheroma
- iMap-Intravascular Ultrasound Radiofrequency Signal Analysis Reflects Plaque Components of Optical Coherence Tomography-Derived Thin-Cap Fibroatheroma
Related Links
- Looking for online definition of lipidic in the Medical Dictionary? lipidic explanation free. What is lipidic? Meaning of lipidic medical term. What does lipidic mean? Lipidic | definition of lipidic by Medical dictionary http://medical ...
- ... lipidic pronunciation, lipidic translation, English dictionary definition of lipidic. also lip·ide n. Any of a group of organic compounds, including the fats, oils, waxes, sterols, and triglycerides, that are insoluble in water but soluble ...
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- 関
- aliphatic、fat、fatty、lipid、lipidic、lipo、lipogenous