- adv.
- 致死的に
WordNet
- bringing death
- controlled or decreed by fate; predetermined; "a fatal series of events" (同)fateful
- with fatal consequences or implications; "he was fatally ill equipped for the climb"
PrepTutorEJDIC
- 『運命の』,宿命的な,避けられない(inevitable) / 『致命的な』,命にかかわる
- 死をもたらす,致死の;死をもたらす目的の
UpToDate Contents
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- 1. 再生不良性貧血：病因、臨床症状および診断 aplastic anemia pathogenesis clinical manifestations and diagnosis
- 2. 造血幹細胞の分布 sources of hematopoietic stem cells
- 3. 頭頚部癌の放射線抵抗性を克服するための方法 methods to overcome radiation resistance in head and neck cancer
- 4. 同種造血細胞移植後の免疫再構築のための戦略 strategies for immune reconstitution following allogeneic hematopoietic cell transplantation
- 5. 胃癌の病理および分子学的病因 pathology and molecular pathogenesis of gastric cancer
English Journal
- Survival Efficacy of the PEGylated G-CSFs Maxy-G34 and Neulasta in a Mouse Model of Lethal H-ARS, and Residual Bone Marrow Damage in Treated Survivors.
- Chua HL, Plett PA, Sampson CH, Katz BP, Carnathan GW, Macvittie TJ, Lenden K, Orschell CM.Author information *Indiana University School of Medicine, Indianapolis, IN; †University of Maryland School of Medicine, Baltimore, MD; ‡Maxygen, Inc., San Mateo, CA.AbstractIn an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS), along with the lead MCM for licensure and stockpiling, G-CSF. Both PEG-G-CSFs were shown to retain significant survival efficacy when administered as a single dose 24 h post-exposure, compared to the 16 daily doses of G-CSF required for survival efficacy. Furthermore, 0.1 mg kg of either PEG-G-CSF affected survival of lethally-irradiated mice that was similar to a 10-fold higher dose. The one dose/low dose administration schedules are attractive attributes of radiation MCM given the logistical challenges of medical care in a mass casualty event. Maxy-G34-treated mice that survived H-ARS were examined for residual bone marrow damage (RBMD) up to 9 mo post-exposure. Despite differences in Sca-1 expression and cell cycle position in some hematopoietic progenitor phenotypes, Maxy-G34-treated mice exhibited the same degree of hematopoietic stem cell (HSC) insufficiency as vehicle-treated H-ARS survivors in competitive transplantation assays of 150 purified Sca-1+cKit+lin-CD150+cells. These data suggest that Maxy-G34, at the dose, schedule, and time frame examined, did not mitigate RBMD but significantly increased survival from H-ARS at one-tenth the dose previously tested, providing strong support for advanced development of Maxy-G34, as well as Neulasta, as MCM against radiation.
- Health physics.Health Phys.2014 Jan;106(1):21-38. doi: 10.1097/HP.0b013e3182a4df10.
- In an effort to expand the worldwide pool of available medical countermeasures (MCM) against radiation, the PEGylated G-CSF (PEG-G-CSF) molecules Neulasta and Maxy-G34, a novel PEG-G-CSF designed for increased half-life and enhanced activity compared to Neulasta, were examined in a murine model of t
- PMID 24276547
- A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G2/M Phases.
- Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.Author information Authors' Affiliations: Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Center for innovative clinical medicine, Okayama University Hospital, Okayama; Oncolys BioPharma, Inc., Tokyo, Japan; Department of Surgery, University of California San Diego; and AntiCancer, Inc., San Diego, California.AbstractPURPOSE: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem-like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals. However, it is unclear that mobilization of the cell cycle can eliminate quiescent cancer stem-like cells in solid cancers. Thus, we explored the use of a genetically-engineered telomerase-specific oncolytic adenovirus, OBP-301, to mobilize the cell cycle and kill quiescent cancer stem-like cells.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2013 Dec 1;19(23):6495-505. doi: 10.1158/1078-0432.CCR-13-0742. Epub 2013 Sep 30.
- PURPOSE: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem-like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals. However, it is unclear that mobilization of the cell cycle can eli
- PMID 24081978
- Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice.
- Flores C, Moscatelli I, Thudium CS, Gudmann NS, Thomsen JS, Brüel A, Karsdal MA, Henriksen K, Richter J.Author information johan.richter@med.lu.se.AbstractThe osteoclast is vital for establishment of normal hematopoiesis in the developing animal. However, its role for maintenance of hematopoiesis in adulthood is more controversial. To shed more light on this process, we transplanted hematopoietic stem cells from two osteopetrotic mouse models, with lack of osteoclasts or defective osteoclast function, to normal adult mice and examined the bone phenotype and hematopoiesis in the recipients. B6SJL mice were lethally irradiated and subsequently transplanted with oc/oc, Receptor Activator of Nuclear Factor Kappa B knockout or control fetal liver cells. Osteoclasts derived from the recipient animals were tested in vitro for osteoclastogenesis and resorptive function. Bone remodeling changes were assessed using biomarkers of bone turnover and micro-CT. Hematopoiesis was assessed by flow cytometry and colony formation, and hematopoietic stem cell function by secondary competitive transplantations and cell cycle analysis. After transplantation, a donor chimerism of 97-98% was obtained, and by 15 weeks mild osteopetrosis had developed in recipients of cells from osteopetrotic mice. There were no alterations in the number of bone marrow cells. Colony formation was slightly reduced in Receptor Activator of Nuclear Factor Kappa B knockout recipients but unchanged in oc/oc recipients. Phenotypically, stem cells were marginally reduced in recipients of cells from osteopetrotic mice, but no significant difference was seen in cell cycle status and in competitive secondary transplantations all three groups performed equally well. Our results indicate that osteoclast function is not crucial for hematopoietic stem cell maintenance in adult mice.
- Haematologica.Haematologica.2013 Dec;98(12):1848-55. doi: 10.3324/haematol.2013.089466. Epub 2013 Oct 4.
- The osteoclast is vital for establishment of normal hematopoiesis in the developing animal. However, its role for maintenance of hematopoiesis in adulthood is more controversial. To shed more light on this process, we transplanted hematopoietic stem cells from two osteopetrotic mouse models, with la
- PMID 24097632
Japanese Journal
- The engraftment and differentiation of transplanted bone marrow-derived cells in the olfactory bulb after methimazole administration
- Noda Yohei,Nishizaki Kazunori,Yoshinobu Junko,Orita Yorihisa,Tsujigiwa Hidetsugu,Yamada Masao
- Acta Oto-laryngologica 133(9), 951-956, 2013-09
- … Methods: Bone marrow of GFP (green fluorescence protein) mice was transplanted into lethally irradiated recipient mice. …
- NAID 120005359096
- Retinal sensitivity after resolution of the macular edema associated with retinal vein occlusion.
- Ota Masafumi,Tsujikawa Akitaka,Ojima Yumiko,Miyamoto Kazuaki,Murakami Tomoaki,Ogino Ken,Akagi-Kurashige Yumiko,Muraoka Yuki,Yoshimura Nagahisa
- Graefe's archive for clinical and experimental ophthalmology 250(5), 635-644, 2012-05
- … [Conclusion ]Retinal function was decreased markedly in areas with a damaged photoreceptor layer due to RVO, and was lethally decreased within nonperfused areas. …
- NAID 120004397857
- 嗅組織と再生医療
- 西崎 和則
- 耳鼻咽喉科臨床 104(5), 309-315, 2011-05-01
- … We transplanted bone marrow cells of green fluorescence protein (GFP) mice into lethally irradiated recipients. …
- NAID 10027972503
Related Links
- Lethally definition, of, relating to, or causing death; deadly; fatal: a lethal weapon; a lethal dose. See more. Thesaurus Translate Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In A lot ...
- Asian populations were the victim of a veterinary drug, diclofenac, which is used to treat inflammation in livestock but which is lethally toxic to vultures when they ingest it from carcasses, with numbers plummeting faster than the Dodo ...
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★リンクテーブル★
| リンク元 | 「fatal」「致死的」「fatally」 |
| 関連記事 | 「lethal」 |
「fatal」
- adj.
- 致死的な、致命的な
「致死的」
「fatally」
- adv.
- 致死的に
「lethal」
- adj.
- 致死的な、致命的な、致死の、致死性の