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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/21 09:49:58」(JST)

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Lentinan is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake (Lentinula edodes). Lentinan has been approved as an adjuvant for stomach cancer in Japan since 1985.[1] Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.

Chemistry [edit]

Lentinan is a β-1,3 beta-glucan with β-1,6 branching. Molecular weight of lentinan is 500,000 Da. Specific rotation +14-22° (NaOH).

Research [edit]

Lentinex is a formulation featuring lentinan and is approved for use in the EU. An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.^[1] A pharmacological blend (MC-S) of lentinan, PSK, Ganoderma lucidum and Astragalus propinquus has also been shown to stimulate white blood cell production in vitro. ^[2]

An in vivo experiment on mice, revealed lentinan is orally active (since clinical use of the drug is administered through an IV).^[3]

Limited clinical studies of cancer patients have associated lentinan with a higher survival rate, higher quality of life, and lower re-occurrence of cancer.^[4]^[5]^[6]^[7]^[8]^[9]^[10]^[11]

Notes [edit]

^ Sia GM, Candlish JK. (Mar 1999). "Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line.". Phytother Res. 13 (2): 133–7. doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O. PMID 10190187
^ Clark D, Adams M. (2007). "Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support on non-stimulated human lymphocytes.". Austr. J. Med. Herbal. 19: 108–111
^ Ng ML, Yap AT. (Oct 2002). "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes).". J Altern Complement Med. (National University of Singapore) 8 (5): 581–9. doi:10.1089/107555302320825093. PMID 12470439
^ Yang P, Liang M, Zhang Y, Shen B. (Aug 2008). "Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.". Adv Ther. 25 (8): 787–94. doi:10.1007/s12325-008-0079-x. PMID 18670743
^ Nimura H, Mitsumori N, Takahashi N, (Jun 2006). "[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]". Gan to Kagaku Ryoho. 33 (1): 106–9. PMID 16897983
^ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.". Hepatogastroenterology. 46 (28): 2662–8. PMID 10522061
^ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer". Anticancer Res. 29 (7): 2739–45. PMID 19596954.
^ Hazama S, Watanabe S, Ohashi M, et al. (July 2009). "Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer". Anticancer Res. 29 (7): 2611–7. PMID 19596936.
^ Kataoka H, Shimura T, Mizoshita T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life". Hepatogastroenterology 56 (90): 547–50. PMID 19579640.
^ Isoda N, Eguchi Y, Nukaya H, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma". Hepatogastroenterology 56 (90): 437–41. PMID 19579616.
^ Shimizu K, Watanabe S, Watanabe S, et al. (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepatogastroenterology 56 (89): 240–4. PMID 19453066.

References [edit]

Chihara, G. et al. ”Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom)”, Cancer Research (1970),30(11):2776-2781.
Ina, K. et al. “Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy”, World Journal of Clinical Oncology (2011),2(10):339-343.

External links [edit]

Lentinan effects (antitumor and others)
Memorial Sloan-Kettering Cancer Center's page for Lentinan.
About Shiitake (by Solomon P. Wasser, 2005)
Smith JE, Rowan NJ, Sullivan R Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments Cancer Research UK, 2001

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Effects of tumor-specific antigen induced by lentinan on murine H22 hepatocellular carcinoma immunoprophylaxis.

Wang Y1, Han X, Li YD, Zhao SY, Zhang DJ, ZhaO ZH, Wang YB.
European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2015 Dec;19(23):4516-24.
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most prevalent tumor types and the third most common form of morbidity in cancer-related deaths worldwide. Lentinan isolated from Lentinus edodes, is known to be a biologically active macromolecule with extremely strong activation of the human
PMID 26698247

A meta-analysis of lentinan injection combined with chemotherapy in the treatment of nonsmall cell lung cancer.

Yin X, Ying J, Li L, Zhang H, Wang H1.
Indian journal of cancer.Indian J Cancer.2015 Nov;52 Suppl:E29-31. doi: 10.4103/0019-509X.168953.
OBJECTIVE: To systematic review and analysis the clinical efficacy and toxicity of lentinan injection combined with chemotherapy in the treatment of nonsmall cell lung cancer (NSCLC).MATERIALS AND METHODS: The databases of PubMed and CNKI were electronic searched with the free text word of lung canc
PMID 26548936

Optimization of selenizing conditions for Seleno-Lentinan and its characteristics.

Ren G1, Li K1, Hu Y1, Yu M2, Qu J3, Xu X4.
International journal of biological macromolecules.Int J Biol Macromol.2015 Nov;81:249-58. doi: 10.1016/j.ijbiomac.2015.08.012. Epub 2015 Aug 8.
Lentinan was successfully modified with nitric acid-sodium selenite method based on L9(3(4)) orthogonal experiments. The optimum selenizing conditions were obtained according to selenium conversion rate as follows: Lentinan of 1.0g, pH of 4.5, temperature of 70°C and sodium selenite of 1.50g. The a
PMID 26261081

Japanese Journal

Intestinal Anti-Inflammatory Activity of Lentinan: Influence on IL-8 and TNFR1 Expression in Intestinal Epithelial Cells

PLoS ONE 8(4), e62441, 2013-04-22
NAID 120005602547

PS-045-5 Lentinanによる切除不能進行・再発胃癌に対するTS-1/CDDP(CS)療法の投与継続性改善効果に関する検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

日本外科学会雑誌 114(臨時増刊号_2), 580, 2013-03-05
NAID 110009714924

腫瘍特異的抗原由来ペプチドを用いた癌ワクチン療法 : 臨床試験について

日本口腔腫瘍学会誌 23(4), 111-116, 2011-12-15
NAID 10030796035

「レンチナン」

Lentinan
Systematic (IUPAC) name
	β-D-glucopyranosyl-(1→6)-[β-D-glucopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→3)β-D-glucopyranosyl-(1→3)]-β-D-glucopyranose
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	37339-90-5
ATC code	L03AX01
PubChem	CID 37723
KEGG	D01695
Synonyms	(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6R)-2,3,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,5-dihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Chemical data
Formula	C42H72O36
Mol. mass	1152.99948 g/mol
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英: lentinan

免疫強化薬;高分子グルカン

[pmid_.3D_10190187-1] Sia GM, Candlish JK. (Mar 1999). "Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line.". Phytother Res. 13 (2): 133–7. doi:10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O. PMID 10190187

[2] Clark D, Adams M. (2007). "Using commercial nutraceutical mixes as immune stimulants: an in vitro proliferation study using Metabolic Cell-Support on non-stimulated human lymphocytes.". Austr. J. Med. Herbal. 19: 108–111

[pmid_.3D_12470439-3] Ng ML, Yap AT. (Oct 2002). "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes).". J Altern Complement Med. (National University of Singapore) 8 (5): 581–9. doi:10.1089/107555302320825093. PMID 12470439

[pmid_.3D_18670743-4] Yang P, Liang M, Zhang Y, Shen B. (Aug 2008). "Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.". Adv Ther. 25 (8): 787–94. doi:10.1007/s12325-008-0079-x. PMID 18670743

[pmid_.3D_16897983-5] Nimura H, Mitsumori N, Takahashi N, (Jun 2006). "[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]". Gan to Kagaku Ryoho. 33 (1): 106–9. PMID 16897983

[pmid_.3D_10522061-6] Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.". Hepatogastroenterology. 46 (28): 2662–8. PMID 10522061

[pmid19596954-7] Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer". Anticancer Res. 29 (7): 2739–45. PMID 19596954.

[pmid19596936-8] Hazama S, Watanabe S, Ohashi M, et al. (July 2009). "Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer". Anticancer Res. 29 (7): 2611–7. PMID 19596936.

[pmid19579640-9] Kataoka H, Shimura T, Mizoshita T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life". Hepatogastroenterology 56 (90): 547–50. PMID 19579640.

[pmid19579616-10] Isoda N, Eguchi Y, Nukaya H, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma". Hepatogastroenterology 56 (90): 437–41. PMID 19579616.

[pmid19453066-11] Shimizu K, Watanabe S, Watanabe S, et al. (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepatogastroenterology 56 (89): 240–4. PMID 19453066.

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lentinan