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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/27 02:50:56」(JST)

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A lentigo (/lɛnˈtaɪɡoʊ/) (plural lentigines, /lɛnˈtɪdʒɨniz/) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside. This is in contrast to the "nests" of multi-layer melanocytes found in moles (melanocytic nevi). Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer.^[1]^[2]

Lentigines are distinguished from freckles (ephelis) based on the proliferation of melanocytes. Freckles have a relatively normal number of melanocytes but an increased amount of melanin. A lentigo has an increased number of melanocytes. Freckles will increase in number and darkness with sunlight exposure, whereas lentigines will stay stable in their color regardless of sunlight exposure.^[2]

Conditions characterized by lentigines include:^[3]^:686–687

Lentigo simplex
Solar lentigo (Liver spots)
PUVA lentigines
Ink spot lentigo
LEOPARD syndrome
Mucosal lentigines
Multiple lentigines syndrome
Moynahan syndrome
Generalized lentiginosis
Centrofacial lentiginosis
Carney complex
Inherited patterned lentiginosis in black persons
Partial unilateral lentiginosis
Peutz-Jeghers syndrome
Acral lentiginous melanoma

References

^ Random House Webster's Unabridged Dictionary. Random House, Inc. 2001. Page 1101. ISBN 0-375-72026-X.
^ ^a ^b Robbins and Cotran Pathologic Basis of Disease Elsevier. 2005. Page 1232. ISBN 0-8089-2302-1 .
^ William D. James, Timothy G. Berger et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

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1. 色素細胞性母斑（ほくろ）以外の良性色素性皮膚病変 benign pigmented skin lesions other than melanocytic nevi moles
2. 色素沈着過剰を有する患者へのアプローチ approach to the patient with hyperpigmentation disorders
3. クリッペル・トレノネー・ウェーバー症候群：臨床症状、診断、マネージメント klippel trenaunay syndrome clinical manifestations diagnosis and management
4. カーニー複合 carney complex
5. 皮膚色素過剰症に対するレーザーおよび光線療法 laser and light therapy for cutaneous hyperpigmentation

English Journal

The Perimeter Technique in the Surgical Treatment of Lentigo Maligna and Lentigo Maligna Melanoma.

García Bracamonte B, Palencia-Pérez SI, Petiti G, Vanaclocha-Sebastián F.SourceServicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España.
Actas dermo-sifiliograficas.Actas Dermosifiliogr.2012 Oct;103(8):748-750. Epub 2012 Jun 7.
PMID 22683018

AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: A report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery.

Ad Hoc Task Force, Connolly SM, Baker DR, Coldiron BM, Fazio MJ, Storrs PA, Vidimos AT, Zalla MJ, Brewer JD, Smith Begolka W; Ratings Panel, Berger TG, Bigby M, Bolognia JL, Brodland DG, Collins S, Cronin TA Jr, Dahl MV, Grant-Kels JM, Hanke CW, Hruza GJ, James WD, Lober CW, McBurney EI, Norton SA, Roenigk RK, Wheeland RG, Wisco OJ.SourceDepartment of Dermatology, Mayo Clinic, Scottsdale, Arizona.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2012 Oct;67(4):531-50. doi: 10.1016/j.jaad.2012.06.009. Epub 2012 Sep 5.
The appropriate use criteria process synthesizes evidence-based medicine, clinical practice experience, and expert judgment. The American Academy of Dermatology in collaboration with the American College of Mohs Surgery, the American Society for Dermatologic Surgery Association, and the American Soc
PMID 22959232

Japanese Journal

症例汎発性黒子症候群を合併したCoccygeal Padの1例

増岡美穂,三砂範幸,後塚加奈子 [他]
西日本皮膚科 = The Nishinihon journal of dermatology : 日本皮膚科学会西部支部機関誌 75(1), 28-31, 2013-02
NAID 40019594364

Protection and Therapy of Photoaging

Kawada Akira
ANTI-AGING MEDICINE 8(6), 88-91, 2011
… Chronic and repeated sun exposure causes photoaging skin that includes solar lentigines, wrinkles, changes of texture, benign tumors, and cutaneous cancers. … Education in the appropriate use of sunscreens and the significance of SPF and PA is needed.Solar lentigines on the face decrease quality of life. … Then, intense pulsed light (IPL) sources have been developed as noninvasive and nonablative modalities for facial solar lentigines. …
NAID 130001290313

Immuno-histochemical evaluation of solar lentigines : The association of KGF/KGFR and other factors with lesion development

LIN Connie B.,HU Yaping,ROSSETTI Dianne,CHEN Nannan,DAVID Cassarino,SLOMINSKI Andrzej,SEIBERG Miri
Journal of dermatological science 59(2), 91-97, 2010-08-01
NAID 10027401772