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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/20 03:32:41」(JST)

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A lentigo (plural: lentigines) is a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside. This is in contrast to the "nests" of multi-layer melanocytes found in moles (melanocytic nevi). Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer.^[1] ^[2]

Lentigines are distinguished from freckles (ephelis) based on the proliferation of melanocytes. Freckles have a relatively normal number of melanocytes but an increased amount of melanin. A lentigo has an increased number of melanocytes. Freckles will increase in number and darkness with sunlight exposure, whereas lentigines will stay stable in their color regardless of sunlight exposure.^[2]

Conditions characterized by lentigines include:^[3]^:686-687

Lentigo simplex
Solar lentigo (Liver spots)
PUVA lentigines
Ink spot lentigo
LEOPARD syndrome
Mucosal lentigines
Multiple lentigines syndrome
Moynahan syndrome
Generalized lentiginosis
Centrofacial lentiginosis
Carney complex
Inherited patterned lentiginosis in black persons
Partial unilateral lentiginosis
Peutz-Jeghers syndrome
Acral lentiginous melanoma

References

^ Random House Webster's Unabridged Dictionary. Random House, Inc. 2001. Page 1101. ISBN 037572026.
^ ^a ^b Robbins and Cotran Pathologic Basis of Disease Elsevier. 2005. Page 1232. ISBN 0-8089-2302-1 .
^ William D. James, Timothy G. Berger, et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

UpToDate Contents

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1. 色素細胞性母斑（ほくろ）以外の良性色素性皮膚病変 benign pigmented skin lesions other than melanocytic nevi moles
2. 悪性黒子：臨床症状、診断、およびマネージメント lentigo maligna clinical manifestations diagnosis and management
3. 皮膚の良性病変の概要 overview of benign lesions of the skin
4. モース手術 mohs surgery
5. 黒色腫の病理学的特徴 pathologic characteristics of melanoma

English Journal

Evaluation of the role of routine melan-a immunohistochemistry for exclusion of microinvasion in 120 cases of lentigo maligna.

Suchak R1, Hameed OA, Robson A.
The American Journal of dermatopathology.Am J Dermatopathol.2014 May;36(5):387-91. doi: 10.1097/DAD.0b013e3182a3877a.
BACKGROUND: To assess the usefulness of routine melan-A immunohistochemistry (IHC) for exclusion of microinvasion in lentigo maligna (LM).METHODS: One hundred and twenty cases of LM from our archives were reviewed by 2 authors with S100 protein and melan-A IHC using a red chromogen.RESULTS: Melan-A
PMID 24394300

Penile lentigo (genital mucosal macule) following annular lichen planus: a possible association?

Isbary G1, Dyall-Smith D, Coras-Stepanek B, Stolz W.
The Australasian journal of dermatology.Australas J Dermatol.2014 May;55(2):159-61. doi: 10.1111/ajd.12169.
PMID 24720431

Melanoma Patients under Vemurafenib: Prospective Follow-Up of Melanocytic Lesions by Digital Dermoscopy.

Perier-Muzet M1, Thomas L1, Poulalhon N2, Debarbieux S2, Bringuier PP3, Duru G4, Depaepe L5, Balme B5, Dalle S6.
The Journal of investigative dermatology.J Invest Dermatol.2014 May;134(5):1351-8. doi: 10.1038/jid.2013.462. Epub 2013 Nov 7.
Second primary melanomas (SPMs) induced by vemurafenib have been recently described. The aim of this study was to define the dermoscopical signs of melanoma in this context. Patients underwent a total body examination before receiving vemurafenib. Each single melanocytic lesion was registered before
PMID 24304815