レノグラスチム
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/05 21:59:01」(JST)
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Lenograstim
| Clinical data |
| Trade names |
Euprotin, Granocyte, Lenobio, Neutrogin |
| AHFS/Drugs.com |
International Drug Names |
| Identifiers |
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CAS Registry Number
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135968-09-1 N |
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ATC code
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L03AA10 |
| UNII |
6WS4C399GB Y |
| Chemical data |
| N (what is this?) (verify) |
Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator.[1][2] It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
References
- ^ "USAN Council. List No. 340. New names. Lenograstim". Clin. Pharmacol. Ther. 52 (1): 113. July 1992. PMID 1284891.
- ^ Amadori S, Suciu S, Jehn U, Stasi R, Thomas X, Marie JP, Muus P, Lefrère F, Berneman Z, Fillet G, Denzlinger C, Willemze R, Leoni P, Leone G, Casini M, Ricciuti F, Vignetti M, Beeldens F, Mandelli F, De Witte T (July 2005). "Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study". Blood 106 (1): 27–34. doi:10.1182/blood-2004-09-3728. PMC 1895135. PMID 15761020.
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Immunostimulants (L03)
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| Endogenous |
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Cytokines
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Colony-stimulating factors
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- G-CSF
- Filgrastim / Pegfilgrastim
- Lenograstim
- GM-CSF
- Molgramostim
- Sargramostim
- SCF
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Interferons
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- alpha:
- Albinterferon
- Interferon alfa natural
- Interferon alfa 2a / Peginterferon alfa-2a
- Interferon alfa 2b / Peginterferon alfa-2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- beta:
- Interferon beta natural
- Interferon beta 1a
- Interferon beta 1b
- Interferon gamma
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Interleukins
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Other protein / peptide
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- Growth hormone
- Immunocyanin
- Pegademase
- Prolactin
- Tasonermin
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Other
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- Female sex steroids
- Histamine dihydrochloride
- Poly ICLC
- Vitamin D
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| Exogenous |
- beta-glucan
- heterocyclic compound
- hydroxyquinoline
- Mifamurtide
- oligopeptides
- Glatiramer acetate
- Thymopentin
- Thymosin α1
- Thymulin
- polyribonucleotide
- Polyinosinic:polycytidylic acid
- thiazolidine
- vaccines
- Bacillus Calmette–Guérin
- Melanoma vaccine
- Sipuleucel-T
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Index of the immune system
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| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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UpToDate Contents
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English Journal
- Comparison of biosimilar filgrastim, originator filgrastim, and lenograstim for autologous stem cell mobilization in patients with multiple myeloma.
- Lisenko K1, Baertsch MA1, Meiser R1, Pavel P2, Bruckner T3, Kriegsmann M4, Schmitt A1, Witzens-Harig M1, Ho AD1, Hillengass J1, Wuchter P5.
- Transfusion.Transfusion.2017 Oct;57(10):2359-2365. doi: 10.1111/trf.14211. Epub 2017 Jun 26.
- PMID 28653421
- Management and cost analysis of cancer patients treated with G-CSF: a cohort study based on the French national healthcare insurance database.
- Tilleul P1, Jacot W2, Emery C3, Lafuma A3, Gourmelen J4.
- Journal of medical economics.J Med Econ.2017 Sep 4:1-7. doi: 10.1080/13696998.2017.1366324. [Epub ahead of print]
- PMID 28795868
- Biosimilar G-CSF versus filgrastim and lenograstim in healthy unrelated volunteer hematopoietic stem cell donors.
- Farhan R1, Urbanowska E1, Zborowska H2, Król M1, Król M1, Torosian T3, Piotrowska I3, Bogusz K2, Skwierawska K2, Wiktor-Jędrzejczak W1, Snarski E4.
- Annals of hematology.Ann Hematol.2017 Aug 11. doi: 10.1007/s00277-017-3060-4. [Epub ahead of print]
- PMID 28801752
Japanese Journal
- Hepatic Drug Interaction Between Tacrolimus and Lansoprazole in a Bone Marrow Transplant Patient Receiving Voriconazole and Harboring CYP2C19 and CYP3A5 Heterozygous Mutations
- Iwamoto Takuya,Monma Fumihiko,Fujieda Atsushi,Nakatani Kaname,Katayama Naoyuki,Okuda Masahiro
- CLINICAL THERAPEUTICS 33(8), 1077-1080, 2011-08
- … Other drugs taken were acyclovir, ursodeoxycholic acid, cefepime, meropenem, vancomycin, lenograstim and dopamine hydrochloride. …
- NAID 120005133377
- Inductive Potential of Recombinant Human Granulocyte Colony-Stimulating Factor to Mature Neutrophils from X-Irradiated Human Peripheral Blood Hematopoietic Progenitor Cells
- Katsumori Takeo,Yoshino Hironori,Hayashi Masako,Takahashi Kenji,Kashiwakura Ikuo
- Biological and Pharmaceutical Bulletin 32(11), 1849-1853, 2009
- … Filgrastim, Nartograstim, and Lenograstim are clinically available in Japan. … however, Lenograstim is superior to others because of CFU-G-derived colony formation at relatively low doses. … In terms of functional characteristics of neutrophils, Lenograstim-induced neutrophils produced high levels of reactive oxygen species compared to Filgrastim, when rhG-CSF was applied to nonirradiated CD34+ cells. …
- NAID 130000116956
- 多発性骨髄腫患者における自己末梢血幹細胞の高効率な採取法
- 安田 昌宏,坂井田 正光,加藤 博明,横山 裕子,棚橋 純子,下村 順子,高橋 健
- 医療薬学 30(4), 280-287, 2004-04-10
- … When the leukocyte count dropped below 1,000/μL, a granulocyte colony stimulating factor, lenograstim (7.1 ± 2.9μg/kg/day), was administered for around 7 days. …
- NAID 110001171525
Related Links
- lenograstim Verifiedfields = changed | verifiedrevid = 447995983 | IUPAC_name = | image = | tradename = Euprotin, Granocyte, Lenobio, Neutrogin | Drugs.com = International Drug Names | pregnancy_AU = | pregnancy_US ...
- Abstract Lenograstim is the glycosylated recombinant form of human granulocyte colony stimulating factor. The drug is used to reduce the risk of life-threatening infection in patients ... Hollingshead LM, Goa KL. Recombinant ...
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