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1. 内臓リーシュマニア症の疫学および管理 epidemiology and control of visceral leishmaniasis
2. 内臓リーシュマニア症の臨床症状および診断 clinical manifestations and diagnosis of visceral leishmaniasis

Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.

Rashid U1, Sultana R2, Shaheen N3, Hassan SF4, Yaqoob F2, Ahmad MJ2, Iftikhar F2, Sultana N5, Asghar S6, Yasinzai M7, Ansari FL8, Qureshi NA9.
European journal of medicinal chemistry.Eur J Med Chem.2016 Jun 10;115:230-44. doi: 10.1016/j.ejmech.2016.03.022. Epub 2016 Mar 14.
In an attempt to explore novel and more potent antileishmanial compounds to diversify the current inhibitors, we pursued a medicinal chemistry-driven strategy to synthesize novel scaffolds with common pharmacophoric features of dihydropyrimidine and chalcone as current investigational antileishmania
PMID 27017551

Proteome profiling of the growth phases of Leishmania pifanoi promastigotes in axenic culture reveals differential abundance of immunostimulatory proteins.

Alcolea PJ1, Alonso A2, García-Tabares F3, Mena Mdel C4, Ciordia S5, Larraga V6.
Acta tropica.Acta Trop.2016 Jun;158:240-7. doi: 10.1016/j.actatropica.2016.03.015. Epub 2016 Mar 15.
Leishmaniasis is a term that encompasses a compendium of neglected tropical diseases caused by dimorphic and digenetic protozoan parasites from the genus Leishmania (Kinetoplastida: Trypanosomatidae). The clinical manifestations of neotropical cutaneous leishmaniasis (NCL) caused by Leishmania pifan
PMID 26992294

Cross-protective efficacy of Leishmania infantum LiHyD protein against tegumentary leishmaniasis caused by Leishmania major and Leishmania braziliensis species.

Lage DP1, Martins VT2, Duarte MC3, Costa LE1, Tavares Gde S1, Ramos FF3, Chávez-Fumagalli MA1, Menezes-Souza D3, Roatt BM3, Tavares CA2, Coelho EA4.
Acta tropica.Acta Trop.2016 Jun;158:220-30. doi: 10.1016/j.actatropica.2016.03.011. Epub 2016 Mar 11.
Vaccination can be considered the most cost-effective strategy to control neglected diseases, but nowadays there is not an effective vaccine available against leishmaniasis. In the present study, a vaccine based on the combination of the Leishmania-specific hypothetical protein (LiHyD) with saponin
PMID 26976272

Immune Responses in Resistant and Susceptible Strains of CD4-Mutant Mice Infected with Leishmania major

Yamakami Kazuo,Oda Takashi,Watanabe Naoki,Matsuzawa Akio,Nariuchi Hideo,Tadakuma Takushi,Yoshizawa Nobuyuki
Journal of health science 51(1), 55-61, 2005-02-01
… In contrast to wild-type (wt) BALB/c mice, mutant mice of both strains showed decreased parasite replication and an intense leishmanial antigen-specific delayed-type hypersensitivity (DTH) response. … Thus, Th1 and Th2 responses to leishmanial infection are not due to the balance of IL-4/IFN-γ that are produced, but the production of IL-4 determines whether a Th1 or Th2 response will develop. …
NAID 10016656585