ケトール酸レダクトイソメラーゼ
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/30 15:12:13」(JST)
[Wiki en表示]
| ketol-acid reductoisomerase |
| Identifiers |
| EC number |
1.1.1.86 |
| CAS number |
9075-02-9 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a ketol-acid reductoisomerase (EC 1.1.1.86) is an enzyme that catalyzes the chemical reaction
- (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
Thus, the two substrates of this enzyme are (R)-2,3-dihydroxy-3-methylbutanoate and NADP+, whereas its 3 products are (S)-2-hydroxy-2-methyl-3-oxobutanoate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing). Other names in common use include dihydroxyisovalerate dehydrogenase (isomerizing), acetohydroxy acid isomeroreductase, ketol acid reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, 2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid reductoisomerase, acetolactate reductoisomerase, dihydroxyisovalerate (isomerizing) dehydrogenase, isomeroreductase, and reductoisomerase. This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coa biosynthesis.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1NP3, 1QMG, 1YRL, and 1YVE.
References
- Arfin SM, Umbarger HE (1969). "Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium". J. Biol. Chem. 244 (5): 1118–27. PMID 4388025.
- Hill RK, Sawada S & Arfin SM (1979). "Stereochemistry of valine and isoleucine biosynthesis. IV Synthesis, configuration, and enzymatic specificity of alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate". Bioorg. Chem. 8 (2): 175–189. doi:10.1016/0045-2068(79)90003-8.
- Kiritani K, Narise S & Wagner RP (1966). "The reductoisomerase of Neurospora crassa". J. Biol. Chem. 241: 2047–2051.
- Satyanarayana T, Radhakrishnan AN (1965). "Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of Phaseolus radiatus". Biochim. Biophys. Acta 110 (2): 380–8. doi:10.1016/s0926-6593(65)80045-5. PMID 5866387.
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Oxidoreductases: alcohol oxidoreductases (EC 1.1)
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| 1.1.1: NAD/NADP acceptor |
- 3-hydroxyacyl-CoA dehydrogenase
- 3-hydroxybutyryl-CoA dehydrogenase
- Alcohol dehydrogenase
- Aldo-keto reductase
- 1A1
- 1B1
- 1B10
- 1C1
- 1C3
- 1C4
- 7A2
- Aldose reductase
- Beta-Ketoacyl ACP reductase
- Carbohydrate dehydrogenases
- Carnitine dehydrogenase
- D-malate dehydrogenase (decarboxylating)
- DXP reductoisomerase
- Glucose-6-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase
- HMG-CoA reductase
- IMP dehydrogenase
- Isocitrate dehydrogenase
- Lactate dehydrogenase
- L-threonine dehydrogenase
- L-xylulose reductase
- Malate dehydrogenase
- Malate dehydrogenase (decarboxylating)
- Malate dehydrogenase (NADP+)
- Malate dehydrogenase (oxaloacetate-decarboxylating)
- Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
- Phosphogluconate dehydrogenase
- Sorbitol dehydrogenase
- Hydroxysteroid dehydrogenase: 3 Beta
- 11 Beta
- 17 Beta
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| 1.1.2: cytochrome acceptor |
- D-lactate dehydrogenase (cytochrome)
- D-lactate dehydrogenase (cytochrome c-553)
- Mannitol dehydrogenase (cytochrome)
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| 1.1.3: oxygen acceptor |
- Glucose oxidase
- L-gulonolactone oxidase
- Xanthine oxidase
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| 1.1.4: disulfide as acceptor |
- Vitamin K epoxide reductase
- Vitamin-K-epoxide reductase (warfarin-insensitive)
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| 1.1.5: quinone/similar acceptor |
- Malate dehydrogenase (quinone)
- Quinoprotein glucose dehydrogenase
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| 1.1.99: other acceptors |
- Choline dehydrogenase
- L2HGDH
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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- 1. 尿酸腎結石症uric acid nephrolithiasis [show details]
… discussed separately. The two major factors that promote uric acid precipitation are a high urine uric acid concentration and an acid urine pH, which drives the following reaction toward the right, converting …
- 2. 胃酸分泌の生理学physiology of gastric acid secretion [show details]
…deficient mice and HDC-knockout mice have near normal basal acid secretion, a preserved acid secretory response to cholinergic agents, an absent acid secretory response to exogenous gastrin, and hypergastrinemia …
- 3. 尿酸による腎疾患uric acid renal diseases [show details]
… separately. Uric acid is a weak organic acid and exists in one of two forms in biological systems, depending upon the prevailing pH : the sparingly soluble undissociated uric acid form (the most highly …
- 4. 妊娠中の葉酸補充folic acid supplementation in pregnancy [show details]
…consume some folic acid as folate is a natural component of a variety of foods, and grain products in many countries are fortified with folic acid. This topic will discuss the role of folic acid supplementation …
- 5. バルプロ酸中毒valproic acid poisoning [show details]
… Valproic acid (2-propylpentanoic acid; VPA) is a branched-chain carboxylic acid introduced as an anti-epileptic drug in 1978 in the United States. It is used to treat partial and generalized seizures …
English Journal
- Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases.
- Cahn JK, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, Hu Y, Ribbe MW, Arnold FH.
- The Biochemical journal.Biochem J.2015 Apr 7. [Epub ahead of print]
- Although most sequenced members of the industrially important ketol-acid reductoisomerase (KARI) family are Class I enzymes, structural studies to date have focused primarily on the Class II KARIs, which arose through domain duplication. Here, we present five new crystal structures of Class I KARIs.
- PMID 25849365
- Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity.
- Verdel-Aranda K1, López-Cortina ST, Hodgson DA, Barona-Gómez F.
- Microbial biotechnology.Microb Biotechnol.2015 Mar;8(2):239-52. doi: 10.1111/1751-7915.12175. Epub 2014 Oct 9.
- The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketol-acid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this super
- PMID 25296650
- Identification and optimization of a novel thermo- and solvent stable ketol-acid reductoisomerase for cell free isobutanol biosynthesis.
- Reiße S1, Garbe D2, Brück T3.
- Biochimie.Biochimie.2015 Jan;108:76-84. doi: 10.1016/j.biochi.2014.10.024. Epub 2014 Nov 5.
- Due to its enhanced energy content and hydrophobicity, isobutanol is flagged as a next generation biofuel and chemical building block. For cellular and cell-free isobutanol production, NADH dependent (over NADPH dependent) enzyme systems are desired. To improve cell-free isobutanol processes, we cha
- PMID 25446654
Japanese Journal
- ピリミジニルサリチル酸系除草剤による植物アセト乳酸シンターゼ阻害
- 清水 力,中山 礎,中尾 徹,根津 征夫,阿部 洋
- 日本農薬学会誌 19(1), 59-67, 1994
- … The growth inhibition of rice seedlings and chlorella by the herbicides, pyrimidinyl-salicylic acids (PS's) represented by pyrithiobac (2-chloro-6-(4, 6-dimethoxypyrimidine-2-ylthio) benzoic acid) was alleviated almost completely by simultaneous application of three branched-chain amino acids, namely leucine, valine and isoleucine. …
- NAID 110001828252
Related Links
- Ketol-acid reductoisomerase, chloroplastic (Os05g0573700), Ketol-acid reductoisomerase (), Ketol-acid reductoisomerase (Os01g0652600) no protein annotated in this organism no protein annotated in this organism View all . i 2 ...
- To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by-case basis ...
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- 英
- ketol-acid reductoisomerase