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English Journal

Application of liquid chromatography-ion trap mass spectrometry to the characterization of the 16-membered ring macrolide josamycin propionate.

Govaerts C1, Chepkwony HK, Van Schepdael A, Adams E, Roets E, Hoogmartens J.
Journal of mass spectrometry : JMS.J Mass Spectrom.2004 Apr;39(4):437-46.
Coupled liquid chromatography and ion trap mass spectrometry (LC/MS) was used for the characterization of the semi-synthetic 16-membered ring macrolide josamycin propionate. On-line identification of impurities in this antibiotic complex was performed with an ion trap mass spectrometer without recou
PMID 15103658

Multiple dose bioequivalence study with josamycin propionate, a drug with highly variable kinetics, in healthy volunteers.

Van Hoogdalem EJ1, Terpstra IJ, Krauwinkel WJ, Volkers-Kamermans NJ, Baven AL, Verschoor JS.
International journal of clinical pharmacology and therapeutics.Int J Clin Pharmacol Ther.1996 May;34(5):202-7.
Josamycin is a macrolide antibiotic with considerable intra- and interindividual variability in kinetics. In the present study bioequivalence of an intact and dispersed josamycin Solutab tablet, containing 1,000 mg of josamycin in the form of josamycin propionate ester, was tested versus a Josacine
PMID 8738856

A rapid and sensitive high-pressure liquid chromatographic method for monitoring josamycin levels in plasma.

Ducci M, Scalori V.
International journal of clinical pharmacology research.Int J Clin Pharmacol Res.1984;4(3):195-9.
In this study a new high-pressure liquid chromatographic method for monitoring plasma levels of josamycin is described. Josamycin propionate was used as the internal standard. After being extracted from plasma by chloroform at an alkaline pH, the compounds were easily separated on a reversed-phase c
PMID 6490238

立花章男,佐々木弘三,渡辺隆,矢野邦一郎,佐渡卓朗
The Japanese Journal of Antibiotics 28(4), 558-566, 1975
… Josamycin (JM) およびJosamycin propionate(JM-P)を経口投与したときの生体内動態および尿中代謝産物については, すでに報告した1, 2)。 …
NAID 130004130128