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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/27 11:06:30」(JST)

Josamycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces narbonensis var. josamyceticus var. nova

Currently sold in various countries.

Brand examples are:

Europe: Josalid, Josacine, Iosalide, Josamina. Russia: Wilprafen (Вильпрафен). Japan: Josamy.

Adverse effects

There has been a case report of oedema of the feet.^[1]

^ Bosch, X.; Pedrol, E.; Casado, X.; Urbano-Marquez, A. (1993). "Josamycin-induced pedal oedema" (pdf). British Medical Journal (Clinical research ed.) 307 (6895): 26. doi:10.1136/bmj.307.6895.26-a. PMC 1678472. PMID 8343666. edit

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Genital Mycoplasma infections and their resistance phenotypes in an African setting.

Kouegnigan Rerambiah L1, Ndong JC, Medzegue S, Elisee-Ndam M, Djoba Siawaya JF.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.Eur J Clin Microbiol Infect Dis.2015 Jun;34(6):1087-90. doi: 10.1007/s10096-015-2326-9. Epub 2015 Jan 29.
We investigated the antimicrobial susceptibilities of mycoplasmas in Gabonese men and women. A total of 1,332 men and women were included in the study. Sperm, urine, ureteral or vaginal swabs were collected from the subjects. Mycoplasmas identification and antimicrobial susceptibility to azithromyci
PMID 25630539

Occurrence of erythromycin residues in sheep milk. Validation of an analytical method.

García-Mayor MA1, Paniagua-González G1, Soledad-Rodríguez B2, Garcinuño-Martínez RM3, Fernández-Hernando P1, Durand-Alegría JS1.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2015 Apr;78:26-32. doi: 10.1016/j.fct.2014.12.020. Epub 2015 Jan 28.
The paper describes a new and selective analytical sample treatment for quantitative extraction and preconcentration of erythromycin in presence of other macrolide antibiotics in sheep milk samples. The methodology is based on the use of a molecular imprinted polymer (MIP) employed as solid phase ex
PMID 25637760

Kokkayil P, Dhawan B1.
Indian journal of medical microbiology.Indian J Med Microbiol.2015 Apr-Jun;33(2):205-14. doi: 10.4103/0255-0857.154850.
Ureaplasma species are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Ureaplasma has 14 known serotypes and is divided into two biovars- Ureaplasma parvum and Ureaplasma urealyticum. The organism has several genes coding for surface proteins, the most
PMID 25865969

Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs

Tokuda Akira,Ohkura Noriyuki,Fujimura Masaki,Furusho Shiho,Abo Miki,Katayama Nobuyuki
Pulmonary Pharmacology and Therapeutics 23(1), 55-61, 2010-02
… The 14-, 15- or 16-membered macrolides (erythromycin, azythromycin, or josamycin, respectively) were given intraperitoneally every 12 h after the antigen challenge. … Results: The antigen-induced increase in the number of coughs elicited by capsaicin inhalation was significantly reduced by treatments with erythromycin and azythromycin, but not with josamycin. …
NAID 120002061088

Determination of josamycin in rat plasma by capillary electrophoresis coupled with post-column electrochemiluminescence detection

DENG Biyang,KANG Yanhui,LI Xianfeng,XU Qiumei
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 859(1), 125-130, 2007-11-01
NAID 10027466026

竹上晴美,堀江正一,中澤裕之
分析化学 55(9), 651-659, 2006-09-05
高速液体クロマトグラフ/質量分析計(LC/MS)を用いた簡易かつ感度の高い乳中のマクロライド系抗生物質,具体的にはエリスロマシン,オレアンドマイシン,キタサマイシン,ジョサマイシン,ミロサマイシン,ネオスピラマイシン,スピラマイシン,チルミコシン及びタイロシンの同時分析法を検討した.試料の前処理には抽出にアセトニトリルを採用し,ヘキサンによる液液抽出によりクリーンアップを行った.高速液体クロマトグ …
NAID 110004833099

リンク元	「マクロライド系抗菌薬」「ジョサマイシン」「JM」
拡張検索	「josamycin propionate」

Josamycin
Systematic (IUPAC) name
	(2S,3S,4R,6S) -6- {[(2R,3S,4R,5R,6S) -6- {[(4R,5S,6S,7R,9R,10R,11E,13E,16R) -4- (acetyloxy)-10-hydroxy-5-methoxy-9, 16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11, 13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2, 4-dimethyloxan-3-yl 3-methylbutanoate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	16846-24-5
ATC code	J01FA07
PubChem	CID 5284579
DrugBank	DB01321
ChemSpider	4447629
UNII	HV13HFS217
KEGG	D01235
ChEBI	CHEBI:31739
ChEMBL	CHEMBL224436
PDB ligand ID	JOS (PDBe, RCSB PDB)
Chemical data
Formula	C42H69NO15
Mol. mass	827.995 g/mol
	SMILES O=CC[C@H]3C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@H](OC(=O)C[C@@H](OC(=O)C)C(OC)[C@H]3O[C@@H]2O[C@@H]([C@@H](O[C@@H]1O[C@H]([C@@H](OC(=O)CC(C)C)[C@](O)(C1)C)C)[C@H](N(C)C)[C@H]2O)C)C;
	InChI InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39?,40-,41+,42-/m1/s1 ; Key:XJSFLOJWULLJQS-HTYUZQQASA-N ;
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http://www.sigmaaldrich.com/life-science/life-science-catalog/product-catalog.html?TablePage=14572877
Macrolide antibiotics contain a many-membered lactone ring (14-membered rings for erythromycin and clarithromycin and a 15-membered ring for azithromycin) to which are attached one or more deoxy sugars. Clarithromycin differs from erythromycin only by methylation of the hydroxyl group at the 6 position, and azithromycin differs by the addition of a methyl-substituted nitrogen atom into the lactone ring. These structural modifications improve acid stability and tissue penetration and broaden the spectrum of activity.(GOO. chapter 46)